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81.
82.
Microbial cells (E. coli and staphylococcus) and B. cereus spores were used in this work. Peracetic acid in a concentration of 0.005% caused the death of 99% of the microbes in 20 minutes, and 0.1% peracetic acid caused the death of 99% of the spores in 45 minutes. Changes in the surface and internal structures of the cells were revealed on the ultrathin sections of microbial cells and spores after the action of the preparation. The noted changes were explained by disturbance of permeability barrier and a high reactogenic capacity of the activated oxygen of peracetic acid. 相似文献
83.
The diversity of cultured aerobic organisms collected from water samples and bottom sediment from two areas of natural oil
seepage on Lake Baikal has been researched. Representatives of Alpha-, Beta-, and Gammaproteobacteria have been found in samples
collected near the Bol’shaya Zelenovskaya River mouth, while near Cape Gorevoi Utes Betaproteobacteria were absent. Most cultures
are characterized by a sufficiently high homology level (96–100%) with nucleotide sequences from the international database. 相似文献
84.
85.
I G Pavlova 《Arkhiv anatomii, gistologii i émbriologii》1991,101(11-12):5-12
Methods of light microscopy and morphometrical analysis were used for studying semithin sections of the antero-parietal portions of the cortex of neonatal rats from mothers treated by desoxycorticosterone acetate (DOCA) during the last 7 (II group) of last 14 days (III group) of gestation. Animals of the III group were given greater doses of DOCA. Experimental neonatal rats had greater absolute and relative masses of the cerebrum and the thicker cortex: in the II group at the expense of enlargement of neurons, greater amount of glioblasts and the volume of neuropile; in the III group--at the expense of still greater neuron sizes, enlargement of glioblasts and their greater number, as well as the growth of the neuropile volume. In the neocortex of the II group of animals processes of proliferation of glioblasts were more pronounced, greater doses and amount of actions of DOCA (III group) being followed by processes of reinforced differentiation of nerve and glial cells. Experimental animals were found to have greater amount of microgliocytes, hypertrophy of endotheliocyte and pericyte nuclei. Symptoms of blood stagnation and perivascular edema were very rarely noted in neonatal rats of the III group. 相似文献
86.
L S Nazarova I V Isupov L P Pavlova A V Gor'kova M M Intizarov 《Zhurnal mikrobiologii, epidemiologii, i immunobiologii》1986,(10):96-99
Germ-free minipigs, previously treated with bacteroids, develop cholinergic reaction after the intragastric administration of Vibrio cholerae exotoxin. The intensity of this reaction, disturbances in homeostasis, and the character of morphological changes depend on the dose of choleragen, the bacteroid strain, and the presence of the concomitant (Escherichia coli) and residual microflora in the intestine. 相似文献
87.
As revealed in experiments on V. cholerae, the enzymatic link xanthine oxidase-xanthine produces a vibriostatic effect at the concentration of xanthine oxidase equal to 0.0125 g/l and a vibriocidal effect at the concentration of xanthine oxidase equal to 0.025 g/l in a medium with pH 7.5-7.6. In the presence of protein the antivibrionic activity of the xanthine oxidase link is decreased. The introduction of bivalent iron into the enzymatic link xanthine oxidase-xanthine enhances its vibriocidal action on V. cholerae. 相似文献
88.
N F Timchenko O D Novikova T N Pavlova V S Venediktov T F Solov'eva 《Zhurnal mikrobiologii, epidemiologii, i immunobiologii》1990,(11):48-50
The protective properties of the species-specific pore-forming polypeptide of Y. pseudotuberculosis outer membrane (porin) were studied. The study showed that 80-90% of mice immunized with porin survived after challenge with 10-30 LD50 of Y. pseudotuberculosis, serovars 1 and 3. The LD50 of the preparation exceeded its ED50 more than 100-fold. Immunization made in two injections was more effective than immunization in one injection. The immunization of the animals with porin led to an increase in the activity of peritoneal exudate macrophages with respect to Y. pseudotuberculosis, serovars 1 and 3. 相似文献
89.
90.
We have studied the effect of genetic processes in ethnically and demographically diverse isolates on the epidemiology of
complex diseases. Our long-term studies of five indigenous Dagestan ethnic groups have revealed ten genetic isolates with
aggregation of schizophrenia-related diseases. According to Neel’s classification (1992), these isolates belong to primary
and secondary depending on the duration of demographic process. We have found that the average demographic ages of the examined
primary and secondary isolates were about 4000 and 700 years, respectively. The inbreeding level F was studied using two methods: analysis of marriage structure in three generations, which is traditional in population-genetic
studies, and analysis of the same structure in extensive pedigrees (up to 11–13 generations). We have shown that with the
second method, the F value increases two- to threefold in various isolates. The accumulated inbreeding in the primary isolates proved to be twofold
higher than that in the secondary ones. Primary isolates have revealed relatively higher genetic and clinical homogeneity
in combination with higher aggregation of population-specific complex disease pathology compared to secondary isolates. A
decrease in observed recombinations and the number of genomic loci linked with the disease in primary isolates have been also
demonstrated. Thus, our studies showed that complex diseases can be less expensive and mapping of genes for time-consuming
if conducted in primary rather than in secondary isolates, in particular when dealing with genetically heterogeneous outbred
human populations. 相似文献