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51.
Demet Tademir Ayegül Karaküük‐yidoan Mustafa Ulali Tuba Takin‐Tok Emne Eln Oru‐Emre Hasan Bayram 《Chirality》2015,27(2):177-188
A series of new chiral thiosemicarbazones derived from homochiral amines in both enantiomeric forms were synthesized and evaluated for their in vitro antiproliferative activity against A549 (human alveolar adenocarcinoma), MCF‐7 (human breast adenocarcinoma), HeLa (human cervical adenocarcinoma), and HGC‐27 (human stomach carcinoma) cell lines. Some of compounds showed inhibitory activities on the growth of cancer cell lines. Especially, compound 17b exhibited the most potent activity (IC50 4.6 μM) against HGC‐27 as compared with the reference compound, sindaxel (IC50 10.3 μM), and could be used as a lead compound to search new chiral thiosemicarbazone derivatives as antiproliferative agents. Chirality 27:177–188, 2015. © 2014 Wiley Periodicals, Inc. 相似文献
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1. Within the range of the given conditions of measuring static and dynamic properties of the rabbit gastrocnemius muscle the following results were obtained: a) the dependence of the maxima of isotonic shortening upon the relative length of the muscle at constant load is linear; b) the parameters of the non-linear dependence of the passive elastic force of the muscle upon its relative length (measured in series) were identified using asymptotic regression; c) the time course of isotonic contractions (at an interval from 0 to 0.3 s after the beginning of stimulation) could be satisfactorily approximated by responses of a linear system to a step-function; d) the time course of isometric contractions (at an interval from 0 to 0.3 s after the beginning of stimulation) could be closely approximated by responses of a linear system to a step-function. 2. The time constants of isotonic and isometric contractions were determined as the parameters of the corresponding linear systems. 3. The maximum rates of the isometric and isotonic contractions were determined as maxima of the first derivatives of the responses of the corresponding models. 4. The experimental set-up made it possible to compare the values of the parameters concomitantly followed at various muscle lengths and at various loads. 相似文献
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Bohuslav Horák 《Plant Systematics and Evolution》1900,50(5):156-164
Ohne Zusammenfassung 相似文献
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Pavel Husák 《Folia Geobotanica》1982,17(4):421-426
Scattered green was studied in Czechoslovakia by means of the air multispectral photography and of the field observation. According to various repartition and canopy 19 structural types of seattered green were derived. 相似文献
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Frantiek Hindák 《Hydrobiologia》2000,438(1-3):107-116
Morphological variation of trichomes, heterocytes and akinetes in four species classified into the nostocalean genera Aphanizomenon Morren ex Bornet et Flahault or Anabaena Bory (Cyanophyta/Cyanobacteria) was studied from natural samples by LM and illustrated by drawings and micrographs. All investigated species, Aphanizomenon gracile (Lemmerm.) Lemmerm., A. aphanizomenoides (Forti) Komárek et Horecká, Anabaena bergii Ostenfeld, A. minderi Huber-Pestalozzi, occur in the plankton as solitary trichomes, similar to many representatives of the genus Anabaena. Main generic diagnostic characters of Aphanizomenon and Anabaena are discussed. 相似文献