Effects of Δ8- and Δ9-Tetrahydrocannabinol on experimentally induced seizures

Effects of Δ⁸- and Δ⁹-tetrahydrocannabinol (Δ⁸- and Δ⁹-THC) on three experimentally induced seizure models, i.e., audiogenic seizure (AS) test, maximal electroshock seizure (MES) test and pentylenetetrazol (PTZ)-induced seizure test were determined in the audiogenic rat. Both tetrahydrocannabinols possess a dose-related anticonvulsant effect against AS, MES and PTZ-induced maximal seizure. Although anticonvulsant potencies do not significantly differ, Δ⁸THC is three times more neurotoxic than Δ⁹THC. In addition, both THC's are without effect on minimal seizure and lethality induced by PTZ. Furthermore, the low protective indexes (TD50/ED50) determined in this study suggest that Δ⁸ and Δ⁹ THC may have poor therapeutic potentials as antiepileptic drugs.     

CHANGES IN WEIGHT,NITROGEN ACCUMULATION,RESPIRATION AND PHOTOSYNTHESIS DURING GROWTH AND DEVELOPMENT OF SEEDS AND PODS OF PHASEOLUS VULGARIS

The growth and development of pods and seeds of Phaseolus vulgaris are described by the following parameters: fresh and dry weight, length, ratio of fresh weight to length and nitrogen content. Pod and seed development are independent and sequential. Pod photosynthesis contributes only marginally to pod development, but may be significant in refixing CO₂ released in respiration. Pods and seeds do not seem to act simply as competing sinks. Nitrogen accumulation in the seeds begins only when it has ceased in the pods. Ways in which regulation may be achieved are discussed. Manipulation of nitrogen fertilization to enhance seed growth is suggested.