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751.
Laminins are a family of glycoproteins which are ubiquitous components of basement membranes and play key structural and functional roles. Eleven isoforms have been identified to date; each is an alpha beta gamma heterotrimer assembled from a repertoire of five alpha, three beta and two gamma chains. Studies of laminin-11 (alpha 5 beta 2 gamma 1) illustrate the unique expression patterns and distinct functions that can be displayed by laminin isoforms. Laminin-11 is found in the glomerular basement membrane in kidney, in the neuromuscular synaptic cleft in skeletal muscle and in other tissues such as placenta and lung. Mice lacking laminin-11 exhibit defective glomerular filtration and developmental defects in neuromuscular synapse formation, with Schwann cells invading the synaptic cleft. Consistent with these observations, both motoneurons and Schwann cells distinguish laminin-11 from other isoforms in vitro. These results suggest that laminin-11 is a structural component of the basement membrane which influences cell behavior in physiologically relevant ways. A greater understanding of laminin-11 assembly and basement membrane incorporation could provide a logical basis for therapy in merosin-deficient congenital muscular dystrophy. 相似文献
752.
This paper tests the hypothesis that the central nervous system (CNS) learns to organize multijoint movements during a multijoint
‘bouncing pull’ task such that, after practice, motion of the anterior-posterior center of mass (CMAP) more closely resembles that of a conservative, one degree of freedom (DF), inverted pendulum model. The task requires standing
human subjects to produce precise peak pulling forces on a handle while maintaining balance – goals that can be easily accomplished
if movement is organized as in the model. Ten freely standing subjects practiced making brief, bouncing pulls in the horizontal
direction to target forces (20–80% of maximum) for 5 days. Pulling force, body kinematic and force plate data were recorded.
An eight-segment analysis determined sagittal-plane CM motion. We compared the effects of practice on the regression-based
fit between actual and model-simulated CMAP trajectories, and on measures of CMAP phase plane symmetry and parameter constancy that the model predicts. If the CNS learns to organize movements like the inverted
pendulum model, then model fit should improve and all other measures should approach zero after practice. The fit between
modeled and actual CMAP motion did not improve significantly with practice, except for moderate force pulls. Nor did practice increase phase plane
symmetry or parameter constancy. Specifically, practice did not decrease the differences between the pre-impact and rebound
positions or speeds of the CMAP, although speed difference increased with pulling force. CMAP at the end of the movement was anterior to its initial position; the anterior shift increased after practice. Differences
between the pre-pull and balance-recovery ankle torque (T
A) impulses were greater on day 5 and correlated with the anterior shift in CMAP. These results suggest that practice separately influenced the force production and balance recovery phases. A modified model
with damping could not explain the observed behaviors. A modified model using the actual time-varying TA profiles improved fit at lower force levels, but did not explain the increased postural shift after practice. We conclude
that the CNS does not learn to organize movements like the conservative, inverted pendulum model, but rather learned a more
complex form of organization that capitalized on more time-varying controls and more intersegmental dynamics. We hypothesize
that at least one additional DF and at least one time-varying parameter will be needed to explain fully how the CNS learns
to organize multijoint, bouncing pulls made while standing.
Received: 9 January 1997 / Accepted in revised form: 27 May 1997 相似文献
753.
C L Patton 《Experimental parasitology》1972,31(3):370-377
754.
755.
Dorothy E. Patton 《人类与生态风险评估》1998,4(3):657-670
Synthesizing, characterizing, and communicating the risk science information used in environmental decision-making depends in the first instance on the nature and quality of the technical analysis. At the same time, other important features of the risk analysis, features that require special attention to provide context for the analysis as a whole, are frequently overlooked in practice or in presentation. Now, as the field expands to meet new challenges and to include new participants, all practitioners — government, academics, industry, and interest groups — must give renewed emphasis to certain hall marks of sound risk assessment: identifying incomplete information and its influence on the risk assessment process, articulating alternative assumptions and the scientific or policy reasons for choices made among alternatives, describing process considerations and limitations as well as numerical results, and fully informing decision makers, the press, and the interested public. The resulting greater clarity and transparency in the scientific analyses that under lie environmental decision making can enhance credibility and public confidence in the scientific foundation for those decisions. 相似文献
756.
757.
A method for the measurement of total lipid weight in biological and geological lipid samples using the latroscan TH-10 analyzer is described. The method involves the application of small (5 μl) volumes to Chromarods, the focusing of the sample at one point by partial development in chloroform-methanol (1:1) or methanol, and the quantification by flame ionization detection. The small response variation between different sample types did not affect the linearity of the response. The method exhibited a reproducibility of ± 10% of the mean or better for samples ranging from 0.5 to 32 μg. The method, at least as sensitive and precise as microgravimetric procedures for total lipid determinations, allows total lipid measurement of 10 samples in 30 min. 相似文献
758.
Michael T. Walsh Deke Beusse Gregory D. Bossart W. Glenn Young Daniel K. Odell Geoffrey W. Patton 《Marine Mammal Science》1988,4(2):154-162
Ray spines were found associated with various tissues on necropsy of seven Atlantic bottlenose dolphins ( Tursiops truncatus ). In at least six cases they were considered a major factor in the death of the animal. Three mature Tursiops had ray spines located in the lung parenchyma. In two other dolphins the ray spine punctured the lateral chest wall without entering the lung tissue. A sixth Tursiops contained a ray spine located in the liver tissue, while a seventh animal had a ray spine lodged in the pancreas. Five of the dolphins were wild individuals and two had been in captivity for more than one year. These findings indicate that beached dolphins and dolphins in captivity with a chronic history of illness should be examined for the presence of ray spines. Caution should be used in maintaining mixed exhibits of dolphins with stingray species. 相似文献
759.
M.-C. Romey C. Guittard J.-P. Chazalette P. Frossard K.P. Dawson M.A. Patton T. Casals T. Bazarbachi E. Girodon G. Rault D. Bozon F. Seguret J. Demaille M. Claustres 《Human genetics》1999,105(1-2):145-150
We recently reported a novel complex allele in the cystic fibrosis transmembrane regulator ( CFTR) gene, combining a sequence change in the minimal CFTR promoter (-102T>A) and a missense mutation in exon 11 [S549R(T>G)].
Here we compare the main clinical features of six patients with cystic fibrosis (CF) carrying the complex allele [-102T>A+S549R(T>G)]
with those of 16 CF patients homozygous for mutation S549R(T>G) alone. Age at diagnosis was higher, and current age was significantly
higher (P=0.0032) in the group with the complex allele, compared with the S549R/S549R group. Although the proportion of patients with
lung colonization was similar in both groups, the age at onset was significantly higher in the group with the complex allele
(P=0.0022). Patients with the complex allele also had significantly lower sweat test chloride values (P=0.0028) and better overall clinical scores (P=0.004). None of the 22 patients reported in this study had meconium ileus. All 16 patients homozygous for S549R(T>G), however,
were pancreatic insufficient, as compared with 50% of patients carrying the complex allele (P=0.013). Moreover, the unique patient homozygous for [-102T>A+S549R(T>G)] presented with a mild disease at 34 years of age.
These observations strongly suggest that the sequence change (-102T>A) in the CFTR minimal promoter could attenuate the severe clinical phenotype associated with mutation S549R(T>G).
Electronic Publication 相似文献
760.