全文获取类型
收费全文 | 1169篇 |
免费 | 180篇 |
专业分类
1349篇 |
出版年
2022年 | 7篇 |
2021年 | 11篇 |
2018年 | 11篇 |
2017年 | 11篇 |
2016年 | 10篇 |
2015年 | 31篇 |
2014年 | 38篇 |
2013年 | 44篇 |
2012年 | 59篇 |
2011年 | 62篇 |
2010年 | 45篇 |
2009年 | 36篇 |
2008年 | 54篇 |
2007年 | 51篇 |
2006年 | 55篇 |
2005年 | 49篇 |
2004年 | 57篇 |
2003年 | 51篇 |
2002年 | 58篇 |
2001年 | 13篇 |
2000年 | 10篇 |
1999年 | 19篇 |
1998年 | 22篇 |
1997年 | 10篇 |
1995年 | 16篇 |
1994年 | 8篇 |
1992年 | 20篇 |
1991年 | 17篇 |
1990年 | 28篇 |
1989年 | 23篇 |
1988年 | 20篇 |
1987年 | 18篇 |
1986年 | 22篇 |
1985年 | 16篇 |
1984年 | 18篇 |
1983年 | 22篇 |
1982年 | 17篇 |
1981年 | 30篇 |
1980年 | 29篇 |
1979年 | 23篇 |
1978年 | 18篇 |
1977年 | 16篇 |
1976年 | 20篇 |
1974年 | 14篇 |
1973年 | 13篇 |
1972年 | 14篇 |
1971年 | 12篇 |
1970年 | 14篇 |
1969年 | 14篇 |
1967年 | 8篇 |
排序方式: 共有1349条查询结果,搜索用时 15 毫秒
71.
72.
73.
74.
Studies on the mechanism of action of the gal repressor 总被引:8,自引:0,他引:8
S Nakanishi S Adhya M Gottesman I Pastan 《The Journal of biological chemistry》1973,248(17):5937-5942
75.
Ira R. Katz 《生物化学与生物物理学报:生物膜》1980,600(1):195-204
Dopamine synthesis from 3,4-dihydroxy-l-phenylalanine in rat striatal synaptosomes was inhibited by a number of amino acids with aromatic or large aliphatic side chains. Inhibition was not seen when aromatic amino acid decarboxylase activity was measured in disrupted synaptosomes. Similarly, inhibition of dopamine synthesis from tyrosine was seen in the presence of leucine. The inhibition most likely results from interactions of the amino acids with substrate transport across the synaptosome plasma membrane, rather than directly with the catalytic enzymes. The kinetic data obtained are used to infer information about the relevant transport process; they suggest the potential importance of amino acid efflux as a regulatory step. 相似文献
76.
77.
Ira Skvortsova 《Proteomics》2013,13(14):2069-2071
About three decades ago, profilin 1 was described as a 15 kDa small protein. It was later shown that profilin 1 is a tumor suppressor in human carcinomas. Recent proteome‐based data additionally demonstrated that the levels of profilin 1 expression could help to predict malignant tumor aggressiveness, response to anticancer therapy and risk of recurrence development. 相似文献
78.
Lauren C. Smith Leanne Tamm Carroll W. Hughes Ira H. Bernstein 《Attention deficit and hyperactivity disorders》2013,5(1):9-20
There is debate regarding the dimensional versus categorical nature of attention-deficit/hyperactivity disorder (ADHD). This study utilized confirmatory factor analysis to examine this issue. ADHD symptoms rated on interviews and rating scales from a large sample of individuals (ages 3–17, 74 % male, 75 % Caucasian) with ADHD were examined (n = 242). Four potential factor structures were tested to replicate prior findings in a sample with a wide age range and included only participants who met DSM-IV-TR diagnostic criteria for ADHD. Correlations with executive function measures were performed to further assess the separability and validity of the derived factors. The data support a bifactor model with a general ADHD factor and two specific factors, inattention and hyperactivity/impulsivity. Importantly, the individual factors were also differentially correlated with executive functioning measures. This study adds to a growing literature suggesting both a general component to ADHD, as well as dimensional traits of inattention and hyperactivity/impulsivity, associated with distinct executive functioning profiles. The presence of a general underlying factor contraindicates separating the inattentive and combined subtypes of ADHD into distinct disorders. 相似文献
79.
Shalom Madar Einav Harel Ido Goldstein Yan Stein Ira Kogan-Sakin Iris Kamer Hilla Solomon Elya Dekel Perry Tal Naomi Goldfinger Gilgi Friedlander Varda Rotter 《PloS one》2013,8(4)
Mutations in the p53 tumor suppressor protein are highly frequent in tumors and often endow cells with tumorigenic capacities. We sought to examine a possible role for mutant p53 in the cross-talk between cancer cells and their surrounding stroma, which is a crucial factor affecting tumor outcome. Here we present a novel model which enables individual monitoring of the response of cancer cells and stromal cells (fibroblasts) to co-culturing. We found that fibroblasts elicit the interferon beta (IFNβ) pathway when in contact with cancer cells, thereby inhibiting their migration. Mutant p53 in the tumor was able to alleviate this response via SOCS1 mediated inhibition of STAT1 phosphorylation. IFNβ on the other hand, reduced mutant p53 RNA levels by restricting its RNA stabilizer, WIG1. These data underscore mutant p53 oncogenic properties in the context of the tumor microenvironment and suggest that mutant p53 positive cancer patients might benefit from IFNβ treatment. 相似文献
80.