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91.
Four alkaloids have been isolated from the stem bark of Zatithoxylum decaryi. Three are known, dictamnine skimmianine, 4-methoxy-1- methyl-2-quinolone. The fourth decarine is new; its structure has been established as 9-methoxy-10-hydroxy-2,3-methylenedioxybenzophenanthridine.1  相似文献   
92.
Antarctica is one of the less prone environments for plant invasions, nevertheless a growing number of non-native species have been registered in the last decades with negative effects on native flora. Here we assessed adaptive phenotypic plasticity in three photoprotective traits (non-photochemical quenching, total soluble sugars, and de-epoxidation state of xanthophylls cycle), and fitness-related traits (maximum quantum yield, photosynthetic rate and total biomass) in the invasive species Poa annua and Deschampsia antarctica under current conditions of water availability and those projected by climate change models. In addition, two manipulative experiments in controlled and field conditions were conducted to evaluate the competitive ability and survival of both species under current and climate change conditions. Moreover, we performed an experiment with different water availabilities to assess cell damage as a potential mechanism involved in the competitive ability deployed in both species. Finally, was assessed the plasticity and biomass of both species subject to factorial abiotic scenarios (water × temperature, and water × nutrients) ranging from current to climate change condition. Overall, results showed that P. annua had greater phenotypic plasticity in photoprotective strategies, higher performance, and greater competitive ability and survival than D. antarctica under current and climate change conditions. Also, cell damage, assessed by lipid peroxidation, was significantly greater in D. antarctica when grown in presence of P. annua compared when grown alone. Finally, P. annua showed a greater plasticity and biomass than D. antarctica under the factorial abiotic scenarios, being more evident under a climate change scenario (i.e., higher soil moisture). Our study suggests that the high adaptive plasticity and competitive ability deployed by P. annua under current and climate change conditions allows it to cope with harsh abiotic conditions and could help explain its successful invasion in the Antarctica.  相似文献   
93.
94.
Sex‐determination mechanisms vary both within and among populations of common frogs, opening opportunities to investigate the molecular pathways and ultimate causes shaping their evolution. We investigated the association between sex‐chromosome differentiation (as assayed from microsatellites) and polymorphism at the candidate sex‐determining gene Dmrt1 in two Alpine populations. Both populations harboured a diversity of X‐linked and Y‐linked Dmrt1 haplotypes. Some males had fixed male‐specific alleles at all markers (“differentiated” Y chromosomes), others only at Dmrt1 (“proto‐” Y chromosomes), while still others were genetically indistinguishable from females (undifferentiated X chromosomes). Besides these XX males, we also found rare XY females. The several Dmrt1 Y haplotypes differed in the probability of association with a differentiated Y chromosome, which we interpret as a result of differences in the masculinizing effects of alleles at the sex‐determining locus. From our results, the polymorphism in sex‐chromosome differentiation and its association with Dmrt1, previously inferred from Swedish populations, are not just idiosyncratic features of peripheral populations, but also characterize highly diverged populations in the central range. This implies that an apparently unstable pattern has been maintained over long evolutionary times.  相似文献   
95.
96.
To acquire system-level understanding of the intercellular junctional complex, protein–protein interactions occurring at the junctions of simple epithelial cells have been examined by network analysis. Although proper hubs (i.e., very rare proteins with exceedingly high connectivity) were absent from the junctional network, the most connected (albeit nonhub) proteins displayed a significant association with essential genes and contributed to the “small world” properties of the network (as shown by in vivo and in silico deletion, respectively). In addition, compared with a random network, the junctional network had greater tendency to form modules and subnets of densely interconnected proteins. Module analysis highlighted general organizing principles of the junctional complex. In particular, two major modules (corresponding to the tight junctions and to the adherens junctions/desmosomes) were linked preferentially to two other modules that acted as structural and signaling platforms.  相似文献   
97.
Most studies in evolution are centered on how homologous genes, structures, and/or processes appeared and diverged. Although historical homology is well defined as a concept, in practice its establishment can be problematic, especially for some morphological traits or developmental processes. Metamorphosis in chordates is such an enigmatic character. Defined as a spectacular postembryonic larva-to-adult transition, it shows a wide morphological diversity between the different chordate lineages, suggesting that it might have appeared several times independently. In vertebrates, metamorphosis is triggered by binding of the thyroid hormones (THs) T(4) and T(3) to thyroid-hormone receptors (TRs). Here we show that a TH derivative, triiodothyroacetic acid (TRIAC), induces metamorphosis in the cephalochordate amphioxus. The amphioxus TR (amphiTR) mediates spontaneous and TRIAC-induced metamorphosis because it strongly binds to TRIAC, and a specific TR antagonist, NH3, inhibits both spontaneous and TRIAC-induced metamorphosis. Moreover, as in amphibians, amphiTR expression levels increase around metamorphosis and are enhanced by THs. Therefore, TH-regulated metamorphosis, mediated by TR, is an ancestral feature of all chordates. This conservation of a regulatory network supports the homology of metamorphosis in the chordate lineage.  相似文献   
98.
River-reef connectivity in the Meso-American Region   总被引:2,自引:2,他引:0  
The accumulation and seasonal impact of riverine discharge on coral reefs of the Meso-American Region (MAR) were estimated using a numerical simulation of river runoff dispersion. River-reef connectivity, or source-sink dynamics of terrestrial runoff was further assessed from more than 400 watersheds of the region onto discrete coral reef areas. Using land use for 2003 and 2004 in the MAR, this work builds upon a Regional Ocean Modeling System simulation of the MAR validated by ocean color satellite data, and on the monthly river nutrient and sediment load and discharge provided by the World Resources Institute using the N-SPECT model. Analysis of the variability of simulated runoff transport to the reefs showed that reefs of the Mesoamerican Barrier Reef System (MBRS) were mostly impacted from June to September, following the peak time of river discharge. At that time, the coastal and oceanic circulations contribute quickly to expel the runoff from the MBRS. High runoff concentration waters leaving the eastern coast of Honduras during the months of October to December return to the southwestern MAR in March as they are entrained in a cyclonic gyre. Coral reefs of the MAR are thus impacted twice, first from the coastal side with runoff of local origin and later from the oceanic side with runoff from mixed origin. High probability of connectivity between rivers and remote reefs is established as this study revealed that river runoff from the north shore of Honduras has a wide-spread impact on most of the coral reefs of southern Belize, while watersheds on the Gulf of Honduras are mostly connected to coral reefs in the northern shore of Honduras. Although the level of remote influence (or runoff concentration reaching the reef) is lower than the local, the cumulative effect of numerous remote river-reef connections remains significant. Communicated by Biology Editor Michael Lesser  相似文献   
99.
Little, M. P., Tawn, E. J., Tzoulaki, I., Wakeford, R., Hildebrandt, G., Paris, F., Tapio, S. and Elliott, P. A Systematic Review of Epidemiological Associations Between Low and Moderate Doses of Ionizing Radiation and Late Cardiovascular Effects, and Their Possible Mechanisms. Radiat. Res. 169, 99-109 (2008). The link between high doses of ionizing radiation and damage to the heart and coronary arteries is established. In this paper, we systematically review the epidemiological evidence for associations between low and moderate doses (<5 Gy) of ionizing radiation and late-occurring cardiovascular disease. Risks per unit dose in epidemiological studies vary over at least two orders of magnitude, possibly a result of confounding factors. An examination of possible biological mechanisms indicates that the most likely causative effect of radiation exposure is damage to endothelial cells and subsequent induction of an inflammatory response, although it seems unlikely that this would extend to low-dose and low-dose-rate exposure. However, a role for somatic mutation has been proposed that would indicate a stochastic effect. In the absence of a convincing mechanistic explanation of epidemiological evidence that is less than persuasive at present, a cause-and-effect interpretation of the reported statistical associations cannot be reliably inferred, although neither can it be reliably excluded. Further epidemiological and biological evidence will allow a firmer conclusion to be drawn.  相似文献   
100.
As the science of connectivity evolves, so too must the management of coral reefs. It is now clear that the spatial scale of disturbances to coral reef ecosystems is larger and the scale of larval connectivity is smaller than previously thought. This poses a challenge to the current focus of coral reef management, which often centers on the establishment of no-take reserves (NTRs) that in practice are often too small, scattered, or have low stakeholder compliance. Fished species are generally larger and more abundant in protected reserves, where their reproductive potential is often greater, yet documented demographic benefits of these reproductive gains outside reserves are modest at best. Small reproductive populations and limited dispersal of larvae play a role, as does the diminished receptivity to settling larvae of degraded habitats that can limit recruitment by more than 50%. For “demographic connectivity” to contribute to the resilience of coral reefs, it must function beyond the box of no-take reserves. Specifically, it must improve nursery habitats on or near reefs and enhance the reproductive output of ecologically important species throughout coral reef ecosystems. Special protection of ecologically important species (e.g., some herbivores in the Caribbean) and size-regulated fisheries that capitalize on the benefits of NTRs and maintain critical ecological functions are examples of measures that coalesce marine reserve effects and improve the resilience of coral reef ecosystems. Important too is the necessity of local involvement in the management process so that social costs and benefits are properly assessed, compliance increased and success stories accrued.  相似文献   
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