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81.
Qing Zhang Christophe Didier Wei Kong Pang Yajie Liu Zhijie Wang Sean Li Vanessa K. Peterson Jianfeng Mao Zaiping Guo 《Liver Transplantation》2019,9(30)
Potassium‐ion batteries (PIBs) are an emerging, affordable, and environmentally friendly alternative to lithium‐ion batteries, with their further development driven by the need for suitably performing electrode materials capable of reversibly accommodating the relatively large K+. Layer‐structured manganese oxides are attractive as electrodes for PIBs, but suffer from structural instability and sluggish kinetics of K+ insertion/extraction, leading to poor rate capability. Herein, cobalt is successfully introduced at the manganese site in the KxMnO2 layered oxide electrode material and it is shown that with only 5% Co, the reversible capacity increases by 30% at 22 mA g‐1 and by 92% at 440 mA g‐1. In operando synchrotron X‐ray diffraction reveals that Co suppresses Jahn–Teller distortion, leading to more isotropic migration pathways for K+ in the interlayer, thus enhancing the ionic diffusion and consequently, rate capability. The detailed analysis reveals that additional phase transitions and larger volume change occur in the Co‐doped material as a result of layer gliding, with these associated with faster capacity decay, despite the overall capacity remaining higher than the pristine material, even after 500 cycles. These results assert the importance of understanding the detailed structural evolution that underpins performance that will inform the strategic design of electrode materials for high‐performance PIBs. 相似文献
82.
Hou YP Sun J Pang ZH Lv PC Li DD Yan L Zhang HJ Zheng EX Zhao J Zhu HL 《Bioorganic & medicinal chemistry》2011,19(20):5948-5954
A series of 1,2,4-triazole derivatives containing 1,4-benzodioxan (5a-5q) have been designed, synthesized, structurally determined, and their biological activities were evaluated as potential MetAP2 inhibitors. All the synthesized compounds were first reported. Among the compounds, compound 5k showed the most potent biological activity against HEPG2 cancer cell line (IC(50)=0.81 μM for HEPG2 and IC(50)=0.93 μM for MetAP2), which was comparable to the positive control. Docking simulation by positioning compound 5k into the MetAP2 structure active site was performed to explore the possible binding model. The results of apoptosis and Western-blot assay demonstrated that compound 5k possessed good antitumor activity against HEPG2 cancer cell line. Therefore, compound 5k with potent inhibitory activity in tumor growth inhibition may be a potential antitumor agent against HEPG2 cancer cell. 相似文献
83.
AbstractForest hiking trails may influence local microclimate and biodiversity, but the effects on community structure and diversity of epiphytic bryophytes on trees are currently unknown. Epiphytic bryophytes on 82 Abies faxoniana Rehder & Wilson tree trunks (41 along the hiking trail edge and 41 controls in the forest interior) were investigated at four heights from the ground (10, 50, 120, and 180 cm). At each site, air temperature and humidity were monitored for 1 year. The light radiation levels and air temperature were higher, and the canopy leaf area index and air humidity lower at the trail edge, indicating deterioration in microclimate, resulting from the trail establishment. The epiphytic bryophyte species richness, community cover, and mean cover of dendroid and pendent growth forms on trunks were significantly lower at the trail edge than the control site, suggesting that trail construction caused these reductions. One marked effect of the presence of the trail was the increase in some sun-loving species and decrease in shade-tolerant species. Moreover, the trail also slightly influenced species richness and epiphytic bryophyte cover at both community and species population levels along the height gradient. Comprehensive analyses showed that microclimate deterioration was mainly driven by the trail establishment, and that the change in micro-climate along the trail, rather than any host traits, played an important role in the declining epiphytic bryophyte community structure and diversity at the trail edge, confirming the initial hypothesis that the presence of a raised boardwalk (hiking trail) indirectly influences epiphytic bryophyte community and diversity by altering the microclimate. 相似文献
84.
稀疏效应下周期系数捕食-被捕食系统的全局渐近稳定性 总被引:2,自引:0,他引:2
研究一类稀疏效应下周期系数捕食-被捕食系统,得到了该系统存在唯一全局渐近稳定的正周期解的充分条件. 相似文献
85.
版纳鱼螈和双带鱼螈核型的比较研究 总被引:9,自引:0,他引:9
本文对版纳鱼螈的核型作了观察,并与双带鱼螈进行了比较。两者的核型基本一致,均为2n=42,但版纳鱼螈的NF=62,而双带鱼螈的NF=60;版纳鱼螈的染色体有中部着丝粒、亚中部着丝粒和端部着丝粒三种类型,而双带鱼螈则无亚中部着丝粒的染色体。 相似文献
86.
A new lectin gene was cloned from Amorphophallus konjac. The full-length cDNA of Amorphophallus konjac agglutinin (aka) was 736 bp and contained a 474 bp open reading frame encoding a 158 amino acid protein. Homology analysis revealed that the lectin from this Araceae species belonged to the superfamily of monocot mannose-binding proteins. Molecular modeling of AKA indicated that the three-dimensional structure of AKA strongly resembles that of the snowdrop lectin. Southern blot analysis of the genomic DNA revealed that aka belonged to a low-copy gene family. Northern blot analysis demonstrated that aka expression was tissue-specific with the strongest expression being found in root. 相似文献
87.
Yi Luo Min Wang Zhonghua Pang Fengtao Jiang Jiangning Chen Junfeng Zhang 《The journal of gene medicine》2013,15(11-12):441-452
88.
89.
Lui Ng Timothy Ming-Hun Wan Colin Siu-Chi Lam Ariel Ka-Man Chow Sunny Kit-Man Wong Johnny Hon-Wai Man Hung-Sing Li Nathan Shiu-Man Cheng Ryan Chung-Hei Pak Alvin Ho-Kwan Cheung Thomas Chung-Cheung Yau Oswens Siu-Hung Lo Dominic Chi-Chung Foo Jensen Tung-Chung Poon Ronnie Tung-Ping Poon Roberta Wen-Chi Pang Wai-Lun Law 《PloS one》2015,10(5)
BackgroundThe overall prognosis of colorectal cancer (CRC) patients is unsatisfactory due to cancer metastasis after operation. This study aims to investigate the clinical significance of plasma osteopontin (OPN) levels as minimally invasive, predictive, and surrogate biomarkers for prognosis of CRC patients.MethodsThis randomized study design consists of pre-operative and post-operative plasma samples from a total of 79 patients. We determined plasma levels of OPN by ELISA and examined their correlation with the clinicopathological parameters of CRC patients. The effects of endogenous and exogenous OPN on CRC metastasis were investigated by examination of the effect on regulators of epithelial to messenchymal transition and migration assay.ResultsOur findings demonstrated for the first time the clinical correlation of plasma OPN with metastasis of CRC patients. High post-operative plasma OPN level (>153.02 ng/ml) associated with development of metastasis after curative resection (p<0.001). Moreover, post-operative plasma OPN level correlated with disease-free survival of CRC patients (p=0.009) and was an independent factor for predicting development of metastasis in CRC patients after curative resection (p=0.036). Our in vitro model showed that OPN ectopic expression induced DLD1 cell migration through Snail and Twist1 overexpression and E-cadherin repression, and secretory OPN level enhanced cell migration.ConclusionsThe results of the current study suggest that post-operative plasma OPN correlated with post-operative metastasis, suggesting that it is a potential non-invasive biomarker for the development of future metastasis in CRC patients. In addition, OPN was shown to be involved in the metastatic process and thus inhibition of OPN is a potential therapeutic approach to treat CRC patients. 相似文献
90.
Li‐Fei Bai Hua Zhao Cheng‐Yi Tang Yan‐Jun Pang Rong‐Wu Yang Xiao‐Ming Wang Gui‐Hua Lu Yong‐Hua Yang 《Chirality》2015,27(3):274-280
In this study, a shikonin ester derivative, compound 3g , was selected to evaluate its anticancer activities and we found that compound 3g exhibited better antitubulin activities against the human HepG2 cell line with an IC50 value of 1.097 μM. Furthermore, the inhibition of tubulin polymerization results indicated that compound 3g demonstrated the most potent antitubulin activity (IC50 = 13.88), which was compared with shikonin and colchicine as positive controls (IC50 = 25.28 μM and 22.56 μM), respectively. Compound 3g was simulated to have good binding site with tubulin and arrested the cell cycle at G2/M phase, which also induces apoptosis in HepG2 cells, in which P53 and members of Bcl‐2 protein family were both involved in the progress of apoptosis revealed by western blot. Confocal microscopy observations revealed compound 3g targeted tubulin and altered its polymerization by interfering with microtubule organization. Based on these results, compound 3g functions as a potent anticancer agent targeting tubulin. Chirality 27:274–280, 2015.. © 2015 Wiley Periodicals, Inc. 相似文献