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11.
Jenkins W Perone P Walker K Bhagavathula N Aslam MN DaSilva M Dame MK Varani J 《Biological trace element research》2011,144(1-3):621-635
The purpose of this study was to compare each of the 14 naturally occurring lanthanoid metal ions for ability to stimulate pro-fibrotic responses in human dermal fibroblasts. When fibroblasts were exposed to individual lanthanoids over the concentration range of 1-100?μM, increased proliferation was observed with each of the agents as compared with control cells that were already proliferating rapidly in a growth factor-enriched culture medium. Dose-response differences were observed among the individual metal ions. Matrix metalloproteinase-1 (MMP-1) and tissue inhibitor of metalloproteinase-1 levels were also increased in response to lanthanoid exposure but type I procollagen production was not. A dose-response relationship between induction of proliferation and increased MMP-1 was observed. Non-lanthanoid transition metal ions (aluminum, copper, cobalt, iron, magnesium, manganese, nickel, and zinc) were examined in the same assays; there was little stimulation with any of these metals. When epidermal keratinocytes were examined in place of dermal fibroblasts, there was no growth stimulation with any of the lanthanoids. Several of the lanthanoid metals inhibited keratinocyte proliferation at higher concentrations (50-100?μM). 相似文献
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Bioisosteric approach to the discovery of imidazo[1,2-a]pyrazines as potent Aurora kinase inhibitors
Meng Z Kulkarni BA Kerekes AD Mandal AK Esposite SJ Belanger DB Reddy PA Basso AD Tevar S Gray K Jones J Smith EB Doll RJ Siddiqui MA 《Bioorganic & medicinal chemistry letters》2011,21(1):592-598
Our continued effort toward the development of the imidazo[1,2-a]pyrazine scaffold as Aurora kinase inhibitors is described. Bioisosteric approach was applied to optimize the 8-position of the core. Several new potent Aurora A/B dual inhibitors, such as 25k and 25l, were identified. 相似文献
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Trottier MD Naaz A Kacynski K Yenumula PR Fraker PJ 《Obesity (Silver Spring, Md.)》2012,20(5):1057-1065
Class III obesity is associated with chronic inflammation and a variety of changes in immune function. Yet surprisingly little was known about the status of neutrophils that represent the first line of immune defense. The aim of this study was to assess key functions of neutrophils from class III obese patients, namely phagocytosis, superoxide production, chemotaxis, and response to endotoxin challenge, and compare their responses with lean controls. Thirty obese patients (BMI 48.8 ± 6.6 kg/m(2)) with comorbidities such as diabetes, hyperlipidemia, high blood pressure, etc. and nine lean (BMI between 20 and 25) subjects were enrolled in the study. Neutrophils from class III obese patients phagocytosed Escherichia coli (E. coli) at similar rates and with adequate numbers of bacteria taken up per cell compared with cells from lean subjects. Neutrophil production of superoxide, which is key to rapid killing of pathogens, showed modest diminution in the class III obese, which increased among patients with BMI >50. Chemotactic activity of neutrophils from class III obese patients was not altered. However, neutrophils from obese subjects showed an increased response to low-dose endotoxin, with concomitant reduced apoptosis and extension of their half-life compared with lean subjects, which suggests possible hyperresponsiveness of these neutrophils. Overall, neutrophil activity was not significantly altered by age, gender, diabetic status, or hyperlipidemia. Collectively, these results suggest that class III obese patients, even with comorbidities, have normal or nearly normal phagocytic, chemotactic, and superoxide generating capacity. 相似文献
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Muralidhar?Metta Sriramana?Kanginakudru Narasimharao?Gudiseva Javaregowda?NagarajuEmail author 《BMC genetics》2004,5(1):16
Background
Molecular characterization of cattle breeds is important for the prevention of germplasm erosion by cross breeding. The Indian zebu cattle have their significant role in evolution of present day cattle breeds and development of some of the exotic breeds. Microsatellites are the best available molecular tools for characterization of cattle breeds. The present study was carried out to characterize two Indian cattle breeds, Ongole and Deoni, using microsatellite markers. 相似文献17.
Ranga Rao Ambati Deepika Gogisetty Ravishankar Aswathnarayana Gokare Sarada Ravi Panduranga Narasimharao Bikkina Yuepeng Su 《Critical reviews in biotechnology》2018,38(4):541-558
The enhanced interest in carotenoid research arises partly because of their application in the food and health industries and partly because of the necessity to find a commercially viable natural source for their mass production. The bottlenecks in finding a natural source of carotenoids which can compete with the synthetic products is the mass production of the organism that produces carotenoids, cell harvesting and extraction methods of carotenoids. The microalga Botryococcus braunii is an interesting organism for its commercial value as a rich source of carotenoids. It contains lutein as major carotenoid which is considered to be one of the beneficial carotenoids in human health applications. The current paper reviews the status of B. braunii as an alternative source of carotenoid production on the commercial scale addressing aspects like cultures of algae, factors that enhance the production and accumulation of carotenoids, cell harvesting methods, and carotenoid extraction. The paper also presents an overview of identification, characterization and structural elucidation of carotenoids from B. braunii and their bioactivity. 相似文献
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Ambient aerosols collected from the marine atmospheric boundary layer of the Bay of Bengal and the Arabian Sea have been studied to assess the fractional solubility of aerosol iron, defined as Fews (%)?=?Fews/FeTot?×?100; where FeTot is total aerosol iron and Fews is water soluble iron. The mass concentration of FeTot over the two oceanic regions is not significantly different. However, the fractional solubility is 1–2 orders of magnitude higher over the Bay of Bengal (1.4–24%) compared to that over the Arabian Sea (0.02–0.4%). The spatio-temporal variability in Fews (%) is attributed to differences in the nature of the mineral dust over the two oceanic regions. The Arabian Sea receives coarse dust from desert regions; whereas transport of alluvial dust from the Indo-Gangetic Plain is a dominant source to the Bay of Bengal. The poor fractional solubility (<1%) of Fe from mineral dust, hitherto overestimated in the literature, is documented for the Arabian Sea. A significant linear relationship (P-value?<?0.001) between Fews (%), FeTot and nss-SO4 2? over the Bay of Bengal provides evidence for the chemical processing of mineral dust. Furthermore, the role of anthropogenic sources (biomass burning and fossil-fuel combustion) in enhancing the Fews (%) is discernible from the chemical composition of fine mode (PM2.5) aerosols over the Bay of Bengal. The potential impact of these Fe-dust depositions on phytoplankton carbon fixation and surface ocean biogeochemistry is discussed. 相似文献
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Narasimharao Bhogireddy Ganesh Kumar Veeramachaneni Naga Vamsi Krishna Ambatipudi Pardhasaradhi Mathi Jayasri Ippaguntla Uma Ramani Ganta Sivaji Ganesh Adusumalli Venkata Raman Bokka 《Bioinformation》2013,9(15):788-791
Follicle stimulating hormone (FSH) is a glycoprotein secreted by gonadotrophs of the anterior pituitary gland that regulates
reproduction in mammals. FSH targets its receptor (FSHR) expressed only on grannulosa cells and induce the maturation of
ovarian follicles in females. The levels of both FSH and FSHR rise until the middle of estrus cycle and then falls on level at the time
of ovulation. It is associated with stimulated sertoli cell proliferation in testes and supports spermatogenesis in males. The
interaction between the polypeptide FSH hormone and its corresponding receptor is highly selective. Therefore, it is of interest to
inhibit FSH in the context of infertility. The structure of FSH (PDB ID: 1XWD) is screened using molecular docking techniques
against the ZINC database (a database of 2.7 million compounds) with reference to known standard compounds. This exercise
identifies compounds with better binding and ADMET (Absorption, Digestion, Metabolism, Excretion and Toxicity) properties
compared to known standard compounds. These observations find application for the consideration of such compounds for further
validation towards inhibiting the FSH. 相似文献
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PP Rao NR Hegde YN Reddy 《Journal of virology》2012,86(15):8341; author reply 8342-8341; author reply 8343