全文获取类型
收费全文 | 518篇 |
免费 | 34篇 |
国内免费 | 9篇 |
出版年
2022年 | 3篇 |
2020年 | 5篇 |
2019年 | 3篇 |
2018年 | 6篇 |
2017年 | 10篇 |
2016年 | 10篇 |
2015年 | 12篇 |
2014年 | 8篇 |
2013年 | 20篇 |
2012年 | 20篇 |
2011年 | 16篇 |
2010年 | 19篇 |
2009年 | 26篇 |
2008年 | 23篇 |
2007年 | 13篇 |
2006年 | 17篇 |
2005年 | 9篇 |
2004年 | 17篇 |
2003年 | 11篇 |
2002年 | 6篇 |
2001年 | 10篇 |
2000年 | 5篇 |
1999年 | 9篇 |
1998年 | 5篇 |
1997年 | 8篇 |
1996年 | 14篇 |
1995年 | 6篇 |
1994年 | 7篇 |
1993年 | 7篇 |
1992年 | 6篇 |
1991年 | 4篇 |
1989年 | 3篇 |
1988年 | 4篇 |
1984年 | 3篇 |
1983年 | 4篇 |
1980年 | 4篇 |
1978年 | 5篇 |
1974年 | 5篇 |
1959年 | 7篇 |
1958年 | 23篇 |
1957年 | 26篇 |
1956年 | 26篇 |
1955年 | 22篇 |
1954年 | 22篇 |
1953年 | 13篇 |
1952年 | 13篇 |
1951年 | 10篇 |
1950年 | 9篇 |
1948年 | 2篇 |
1912年 | 2篇 |
排序方式: 共有561条查询结果,搜索用时 31 毫秒
551.
552.
553.
554.
First molecular identification of the vertebrate hosts of Culicoides imicola in Europe and a review of its blood‐feeding patterns worldwide: implications for the transmission of bluetongue disease and African horse sickness
下载免费PDF全文
![点击此处可从《Medical and veterinary entomology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
J. MARTÍNEZ‐DE LA PUENTE J. NAVARRO M. FERRAGUTI R. SORIGUER J. FIGUEROLA 《Medical and veterinary entomology》2017,31(4):333-339
Culicoides (Diptera: Ceratopogonidae) are vectors of pathogens that affect wildlife, livestock and, occasionally, humans. Culicoides imicola (Kieffer, 1913) is considered to be the main vector of the pathogens that cause bluetongue disease (BT) and African horse sickness (AHS) in southern Europe. The study of blood‐feeding patterns in Culicoides is an essential step towards understanding the epidemiology of these pathogens. Molecular tools that increase the accuracy and sensitivity of traditional methods have been developed to identify the hosts of potential insect vectors. However, to the present group's knowledge, molecular studies that identify the hosts of C. imicola in Europe are lacking. The present study genetically characterizes the barcoding region of C. imicola trapped on farms in southern Spain and identifies its vertebrate hosts in the area. The report also reviews available information on the blood‐feeding patterns of C. imicola worldwide. Culicoides imicola from Spain feed on blood of six mammals that include species known to be hosts of the BT and AHS viruses. This study provides evidence of the importance of livestock as sources of bloodmeals for C. imicola and the relevance of this species in the transmission of BT and AHS viruses in Europe. 相似文献
555.
556.
LA Tziveleka D Abatis K Paulus R Bauer C Vagias V Roussis 《Chemistry & biodiversity》2005,2(7):901-909
A series of polyprenylated hydroquinones, quinones, and chromenols were isolated from the extracts of the marine sponge Ircinia spinosula and the brown alga Taonia atomaria, which gave rise to the constituents 1-4 and 5-8, respectively. Compounds 1, 2, 6, and 7 are new natural products, which were fully characterized. Their anti-inflammatory activities in terms of leukotriene formation were evaluated in an in vitro assay with pork leukocytes. The new hydroxylated compound, 2'-[28-hydroxy]heptaprenyl-1',4'-hydroquinone (= 2-[(2E,6E,10E,14E,18Z,22E)-19-(hydroxymethyl)-3,7,11,15,23,27-hexamethyloctacosa-2,6,10,14,18,22,26-heptaen-1-yl]benzene-1,4-diol; 1), the known tetraprenyl benzoquinone sargaquinone (5), and the known polyprenyl chromenols 3 and 4 exhibited the highest anti-inflammatory activities, with IC50 values of 1.9-9.4 microM (Table 3). Potential structure-activity relationships (SAR) are discussed. 相似文献
557.
558.
559.
560.
Luis Rodríguez‐Caso Armando Reyes‐Palomares Francisca Sánchez‐Jiménez Ana R. Quesada Miguel Ángel Medina 《Journal of cellular and molecular medicine》2012,16(12):2872-2893
Angiogenesis, the formation of new vessels from pre‐existing ones, is essential during ontogenetic development and is related to many important physio‐pathological processes in the adult. In fact, a persistent and deregulated angiogenesis is a required event for many diseases and pathological situations, including cancer progression and metastasis. Some rare diseases are also angiogenesis‐related pathologies. However, there is a lack of an exhaustive review on the topic. The main purpose of this work is to carry out a systematic review of literature to determine what (and how much) scientific information concerning angiogenesis‐related rare diseases can be extracted from available sources. After exhaustive searches in bibliographic databases, preselected data were filtered by selecting only those articles on rare diseases with an Orpha number hosted in the Orphanet web. The selected bibliographic references were further curated manually. With the 187 selected references, a critical reading and analysis was carried out allowing for an identification and classification of angiogenesis‐related rare diseases, the involved genes and the drugs available for their treatment, all on the basis of the information available in Orphanet database. 相似文献