全文获取类型
收费全文 | 2697篇 |
免费 | 156篇 |
国内免费 | 209篇 |
出版年
2024年 | 14篇 |
2023年 | 53篇 |
2022年 | 54篇 |
2021年 | 85篇 |
2020年 | 58篇 |
2019年 | 65篇 |
2018年 | 100篇 |
2017年 | 87篇 |
2016年 | 118篇 |
2015年 | 90篇 |
2014年 | 129篇 |
2013年 | 197篇 |
2012年 | 186篇 |
2011年 | 210篇 |
2010年 | 142篇 |
2009年 | 116篇 |
2008年 | 142篇 |
2007年 | 131篇 |
2006年 | 124篇 |
2005年 | 143篇 |
2004年 | 140篇 |
2003年 | 153篇 |
2002年 | 97篇 |
2001年 | 83篇 |
2000年 | 72篇 |
1999年 | 59篇 |
1998年 | 22篇 |
1997年 | 18篇 |
1996年 | 9篇 |
1995年 | 4篇 |
1994年 | 10篇 |
1993年 | 8篇 |
1992年 | 13篇 |
1991年 | 12篇 |
1990年 | 8篇 |
1989年 | 9篇 |
1988年 | 14篇 |
1987年 | 10篇 |
1986年 | 6篇 |
1985年 | 8篇 |
1984年 | 9篇 |
1983年 | 5篇 |
1982年 | 7篇 |
1981年 | 3篇 |
1979年 | 5篇 |
1976年 | 5篇 |
1975年 | 3篇 |
1974年 | 3篇 |
1973年 | 4篇 |
1956年 | 3篇 |
排序方式: 共有3062条查询结果,搜索用时 15 毫秒
21.
Dr. Emrah Ipek Dr. Gamze Sevri Ekren Aşıcı Dr. Erkmen Tuğrul Epikmen Dr. Mürüvvet Abbak Dr. Büşra Kibar Kurt Prof. Dr. Şule Yurdagül Özsoy Prof. Dr. Recai Tunca 《化学与生物多样性》2023,20(7):e202300210
The aim of our study was to investigate the healing effect of propionyl-L-carnitine (PLC) on chronic gastric ulcers and its underlying mechanisms. This study included rats with gastric ulcers induced by applying serosal glacial acetic acid. These rats were then given either saline (vehicle) or PLC at doses of 60 and 120 mg/kg, administered orally 3 days after ulcer induction for 14 consecutive days. Our study found that treatment with PLC resulted in a reduction of the gastric ulcer area, a faster rate of ulcer healing, and stimulated mucosal restoration. Additionally, the treatment with PLC reduced the number of Iba-1+ M1 macrophages while increasing the number of galectin-3+ M2 macrophages, as well as desmin+ microvessels, and α-SMA+ myofibroblasts in the gastric ulcer bed. The mRNA expression of COX-2, eNOS, TGF-β1, VEGFA, and EGF in the ulcerated gastric mucosa was greater in the PLC-treated groups compared with the vehicle-treated rats. In conclusion, these findings suggest that PLC treatment may accelerate gastric ulcer healing by stimulating mucosal reconstruction, macrophage polarization, angiogenesis, and fibroblast proliferation, as well as fibroblast-myofibroblast transition. This process is associated with the upregulation of TGF-β1, VEGFA, and EGF, as well as modulation of the cyclooxygenase/nitric oxide synthase systems. 相似文献
22.
Samet Evyapan Emine Elçin Oruç-Emre Yusuf Sıcak Ayşegül Karaküçük-İyidoğan Gizem Tatar Yılmaz Mehmet Öztürk 《化学与生物多样性》2023,20(8):e202300626
In this study, new chiral thiourea and 1,3-thiazolidine-4,5-dione derivatives were synthesized, it was aimed to evaluate the various biological activities and molecular docking of these compounds. Firstly, the new thioureas ( 1 – 16 ) were obtained by reacting 1-naphthylisothiocyanate with different chiral amines. Then, the chiral thioureas were cyclized with oxalyl chloride to obtain 1,3-thiazolidine-4,5-dione derivatives ( 17 – 32 ). All compounds were evaluated with several in vitro antioxidant and enzyme inhibition activities. Compound 30 was the most active compound against AChE, with a value of IC50=8.09±0.58 μM. On the other hand, all compounds were tested in silico absorption, distribution, metabolism, and excretion (ADME) assays to better understand their bioavailability. These physicochemical properties, pharmacokinetics, and drug-likeness of all compounds were calculated using SwissADME. Furthermore, according to molecular docking analyses compound 30 exhibited significant binding affinities for all enzymes. Based on our overall observations, compound 30 could be recommended as a potential lead for the therapuetic of Alzheimer's. 相似文献
23.
In this study, Schiff bases were synthesized by utilizing the reaction of 4- and 5-aminoindane with substituted benzaldehydes. After the reduction of isolated Schiff bases with NaBH4, the corresponding secondary amine derivatives were obtained. The structures of all synthesized molecules were confirmed by 1H-NMR, 13C-NMR, FT-IR, and ESI-MS. Antioxidant activities of all synthesized molecules were investigated by DPPH method, and IC50 values were calculated. In addition, antibacterial activities of targets were investigated by the well diffusion method, and then MIC99 values were calculated. While only four of the sixteen synthesized molecules showed a high level of antioxidant activity, all of the molecules exhibited biological activity against Gram-positive and Gram-negative bacteria to varying degrees. In addition, all the synthesized molecules showed high antifungal activity. In antioxidant capacity studies, the IC50 values of 2-(((2,3-dihydro-1H-inden-5-yl)amino)methyl)-6-methoxyphenol ( 4 d ) and 2-(((2,3-dihydro-1H-inden-4-yl)amino)methyl)-6-methoxyphenol ( 7 d ) were determined to be 18.1 μg and 35.1 μg, respectively, and these values are much stronger than BHT (butylated hydroxytoluene) and BHA (butylated hydroxyanisole) used as positive controls. The fact that targets have the same core structure with different substituents has revealed a good structure-activity relationship. 相似文献
24.
Summary Taurine which has antioxidant effects is also known to have effects on cell proliferation, inflammation and collagenogenesis. The aim of this study was to investigate the effect of taurine on incisional skin wounds.The mice incised on the dorsal area were divided into control and experimental groups. Saline was injected intraperitoneally to half of the animals in the control group and locally applied to the other half. Fifty mM taurine solution was given intraperitoneally to the first half of the experimental animals and locally to the second half of the experimental group.After four days of treatment, malondialdehyde (MDA) and histamine levels as well as the tensile strength of the wound tissue were measured. Structural alterations in epidermis and dermis were histologically evaluated.The locally administreated taurine significantly increased wound tensile strength by decreasing the MDA and histamine levels and prevented the degranulation of the mast cells. These observations suggest that taurine may be useful on wound healing. 相似文献
25.
On the production,elemental composition (C,N, P) and distribution of photosynthetic organic matter in the Southern Black Sea 总被引:2,自引:1,他引:1
Yılmaz Ayşen Tuğrul Süleyman Polat Çolpan Ediger Dilek Çoban Yeşim Morkoç Enis 《Hydrobiologia》1997,363(1-3):141-155
Chemical oceanographic understanding of the southernBlack Sea has been improved by recent measurements ofthe optical transparency,
phytoplankton biomass (interms of chlorophyll-a and particulate organic matter)and primary productivity. During the spring-autmunperiod
of 1995–1996, light generally penetrated onlyinto the upper 15–40 m, with an attenuation coefficientvarying between 0.125
and 0.350 m2122;1. The averagechlorophyll-a (Chl-a) concentrations for the euphoticzone ranged from 0.1 to 1.5 μg l2122;1. Coherentsub-surface Chl-a maxima were formed near the base ofthe euphotic zone only in summer. Production rate variedbetween
247 and 1925 in the spring and between 405 and687 mgC m2122;2 d2122;1 in the summer-autumn period.The average POM concentrations in the euphotic zonevaried regionally and seasonally between 3.8
and28.6 μm for POC, 0.5 and 3.1 μm for PON and0.02 and 0.1 μm for PP. Atomic ratios of C/N, C/Pand N/P, derived from the regressions
of POM data,ranged between 7.5 and 9.6, 109 and 165, and 11.2 and16.6, respectively. In the suboxic/anoxic interface,the elemental
ratios change substantially due to anaccumulation of PP cohering to Fe and Mn oxides. Thechemocline boundaries and the distinct
chemicalfeatures of the oxic/anoxic transition layer (the so-called suboxic zone) are all located at specificdensity surfaces;
however, they exhibit remarkablespatial and temporal variations both in their positionand in their magnitude, which permit
the definition of long-term changes in the biochemical properties of theBlack Sea upper layer.
This revised version was published online in July 2006 with corrections to the Cover Date. 相似文献
26.
The Sea of Marmara, an intercontinental basin with shallow and narrowstraits, connects the Black and Mediterranean Seas. Data
obtained during1991–1996 have permitted the determination of the elementalcomposition of seston in the euphotic zone and the
N:P ratio of thesubhalocline waters of the Marmara Sea. Since primary production is alwayslimited to the less saline upper
layer (15–20 m), of the Marmara Sea,the subhalocline waters of Mediteranean origin are always rich in nutrients(NO3 + NO2 = 8–10 μm, PO4 = 0.8–1.2 μm) but depleted in dissolvedoxygen (30–50 μm) throughout the basin, yielding an -O_2 : N : P ratio of 178 : 9 : 1. Pollution of the surfacewaters since the 60s has modified the subhalocline nutrient chemistryslightly.
In the euphotic zone, the N : P ratio of the seston changes from5.9 to 9.5 between the less and more productive periods. Though
the biologyof the Marmara has changed significantly during the previous two decades,the close relationship observed between
the elemental composition of thesurface seston and the NO3 : PO4 ratio of thesubhalocline waters strongly suggests that during the whole year primaryproduction throughout the basin and POM
export to the lower layer remainnitrogen-limited. This suggestion needs to be confirmed by bio-assays,biological studies and
sediment trap data from the upper subhaloclinedepths. Nonetheless, the counterflows in the Marmara basin possessrelatively
low N : P ratios in both dissolved and particulate nutrients andextend as far as the adjacent seas.
This revised version was published online in July 2006 with corrections to the Cover Date. 相似文献
27.
25 populations from Turkey and one of Syria belonging to theSabulina section of the genusMinuartia have been karyologically examined. New chromosome numbers have been recorded forM. mesogitana andM. hybrida subsp.turcica, and a new variety was found in theM. hybrida complex. The origin of the taxa with n = 23 and n = 35 is discussed. 相似文献
28.
以化学纯饲料饲养北京的桃蚜 总被引:4,自引:0,他引:4
应用修改后的Dadd和Mitter(1966)全纯饲料配方配制成人工饲料饲养定居在北京温室烟草上的桃蚜 Myzus persicae可完成生活史井连续饲养3代。本文描述饲料配制、饲养和取食量测定的方法。这3代初羽化无翅孤雌胎生雌蚜的平均体重分别为:440±90.7μg,264±104.9μg和312±127.9μg。用放射性同位素稀释法测定取食量的结果得悉若虫期的总取食量每蚜约为1.74μg,相当于1.16μl。 相似文献
29.
In the present work a linear model for a pair of antogonistic muscles is analysed. Each constituent muscle in this model is identical to ones considered previously (Stein and Ouztöreli, 1976). Analytical properties of the antagonistic muscles and dynamics of the system are described and some numerical results are discussed. The natural modes of the system are determined by a fourth order polynomial, which most commonly has one pair of conjugate complex roots and two negative real roots. The filtering of neural inputs through the active state properties of the muscle increases the order of the system to fifth order for these inputs.This work was partly supported by the National Scientific and Engineering Research Council of Canada Grant NRC-A4345 and by the Medical Research Council of Canada Grant MRC-MT-3307 through the University of Alberta 相似文献
30.
M. Namik Oğuztöreli 《Biological cybernetics》1982,44(1):1-8
In a recent work (Ouztöreli, 1980) a mathematical model for studying the neural activities in a vertebrate retina has been investigated, where the basic network contains five interconnected neurons: a receptor cell, a bipolar cell, a horizontal cell, an amacrine cell, and a retinal ganglion cell. More recently, in (Ouztöreli and O'Mara, 1980) the basic network has been extended to a larger network containing twelve neurons. In both of these works, the performances of the basic and extended models were discussed under different structural and processing conditions with constant inputs by using the results of one of our earlier work (Ouztöreli, 1979). In the present paper we investigate by simulations the responses of the basic retinal network to piecewise constant and periodic inputs. The step and frequency responses of the extended retinal network will be discussed in a forthcoming paper.This work was partially supported by the Natural Sciences and Engineering Research Council of Canada under Grant A-4345 through the University of alberta 相似文献