全文获取类型
收费全文 | 135篇 |
免费 | 2篇 |
出版年
2023年 | 2篇 |
2022年 | 3篇 |
2021年 | 7篇 |
2020年 | 2篇 |
2019年 | 1篇 |
2018年 | 2篇 |
2017年 | 2篇 |
2016年 | 5篇 |
2015年 | 6篇 |
2014年 | 9篇 |
2013年 | 13篇 |
2012年 | 8篇 |
2011年 | 9篇 |
2010年 | 6篇 |
2009年 | 6篇 |
2008年 | 6篇 |
2007年 | 12篇 |
2006年 | 4篇 |
2005年 | 3篇 |
2004年 | 9篇 |
2003年 | 3篇 |
2002年 | 4篇 |
2000年 | 2篇 |
1997年 | 1篇 |
1994年 | 1篇 |
1993年 | 3篇 |
1990年 | 1篇 |
1989年 | 1篇 |
1987年 | 2篇 |
1986年 | 1篇 |
1983年 | 2篇 |
1981年 | 1篇 |
排序方式: 共有137条查询结果,搜索用时 78 毫秒
131.
Padmini Dalpadado 《Polar Biology》2002,25(9):656-666
Amphipods from the central and northern areas of the Barents Sea were studied by a series of MOCNESS profiles between 1990 and 1997. Themisto abyssorum, though dominant in warmer Atlantic water, was also present in Arctic water. In contrast, T. libellula was a typical Arctic species and penetrated very little into the Atlantic water masses. T. compressa was seldom found in the studied area. Linear regression analysis showed a statistically significant negative relationship between abundance of T. libellula and the variability in the Atlantic inflow. The abundance of this species seems to be, to a large extent, determined by the amount of Arctic water in the Barents Sea. The sub-Arctic species, T. abyssorum, only has a 1-year life-cycle, with the peak in release of young (2-3 mm) occurring in May and June. A few individuals may survive to be older. The Arctic species, T. libellula, seems to release the young earlier and the length-frequency distributions seem to indicate a 2-year life-span. The spring phytoplankton, which usually blooms during April in the Barents Sea, followed by high abundance of Calanus spp. and krill species, are regarded as important factors that influence the release of the amphipods' young. 相似文献
132.
133.
Dr. P. Padmini Dr. S. K. Rakshit Prof. A. Baradarajan 《Bioprocess and biosystems engineering》1993,9(1):43-46
The immobilization of lipase from Candida lipolytica on alumina by adsorption for the hydrolysis of ricebran oil is described. Some of the factors which influence the activity of immobilizate and the stability of immobilizate are discussed. About 69% of the initially added enzyme activity is found in the biocatalyst when immobilized at pH 7.2. The stability of the immobilized enzyme to different pH and temperature conditions has also been studied.List of Symbols DE
Dextrose equivalent. One DE is reducing sugar equivalent to one milligram of glucose
- NE
Nitrogen equivalent. One NE is one milligram of nitrogen 相似文献
134.
Distribution of 0-group cod (Gadus morhua) and haddock (Melanogrammus aeglefinus) in August–September 2005 and 2006 was mainly restricted to the Atlantic waters of the western and central areas of the Barents
Sea. The main distribution of 0-group fish overlapped largely with areas of high biomass (>7 gm−2 dry weight) of zooplankton. The copepod Calanus finmarchicus and krill Thysanoessa inermis, which are dominant zooplankton species in both Atlantic and boreal waters of the Barents Sea, were the main prey of 0-group
cod and haddock. The main distribution, feeding areas and prey of 0-group cod and haddock overlapped, implying that competition
for food may occur between the two species. However, though their diet coincided to a certain degree, haddock seems to prefer
smaller and less mobile prey, such as Limacina and appendicularians. As 0-group fish increased in size, there seems to be a shift in diet, from small copepods and towards
larger prey such as krill and fish. Overall, a largely pelagic feeding behaviour of 0-group cod and haddock was evident from
this study. 相似文献
135.
V. Uma Maheshwari Nallal R. Padmini B. Ravindran Soon Woong Chang R. Radhakrishnan Hesham Saleh M. Almoallim Sulaiman Ali Alharbi M. Razia 《Saudi Journal of Biological Sciences》2021,28(2):1246-1256
Candida infections and related mortality have become a challenge to global health. Nontoxic and natural bioactive compounds from plants are regarded as promising candidates to inhibit these multidrug resistant strains. In the present study, in vitro assays and in silico molecular docking approach was combined to evaluate the inhibitory effect of crude extracts from Allium ampeloprasum and its variety A. porrum on Candida pathogens. Phytochemical screening revealed the presence of phenolic acids and flavonoids in higher quantity. Spectral studies of the extracts support the presence of phenols, flavonoids and organosulfur compounds. Aqueous extract of A. ampeloprasum showed a total antioxidant capacity of 68 ± 1.7 mg AAE/ g and an IC50 value of 0.88 ± 2.1 mg/ml was obtained for DPPH radicals scavenging assay. C. albicans were highly susceptible (19.9 ± 1.1 mm) when treated with aqueous A. ampeloprasum extract. Minimum inhibitory concentrations were within the range of 19–40 μg/ml and the results were significant (p ≤ 0.05). In silico molecular docking studies demonstrated that bioactive phytocompounds of A. ampeloprasum and A. porrum efficiently interacted with the active site of Secreted aspartyl proteinase 2 enzyme that is responsible for the virulence of pathogenic yeasts. Rosmarinic acid and Myricetin exhibited low binding energies and higher number of hydrogen bond interactions with the protein target. Thus the study concludes that A. ampeloprasum and A. porrum that remain as underutilized vegetables in the Allium genus are potential anti-candida agents and their pharmacologically active compounds must be considered as competent candidates for drug discovery. 相似文献
136.
Mitochondrial heat shock protein 70 (mtHSP70) is found to play a primary role in cellular defense against physiological stress
like exposure to environmental contaminants and helpful in the maintenance of cellular homeostasis by promoting the cell survival.
In the present investigation, the environmental-stress-induced increase in mtHSP70 levels along with the quantification of
apoptosis signal regulating kinase 1 (ASK1) and thioredoxin (Trx) were measured in the liver mitochondria of grey mullets
(Mugil cephalus) collected from the polluted Ennore estuary and the unpolluted Kovalam estuary for a period of 2 years. The results showed
elevated lipid peroxide (LPO) and decreased total antioxidant capacity along with the decrease in mitochondrial viability
percentage. Mitochondrial HSP70, ASK1, and Trx levels were increased under this stress condition. A 42% increase in LPO levels
and 18% decrease in mitochondrial survivality were observed in the polluted-site fish liver mitochondria when compared to
the results of unpolluted estuary. We also report that, under observed oxidative stress condition in Ennore fish samples,
the ASK1 levels are only moderately elevated (13% increase). This may be due to mitochondrial-HSP70-induced adaptive tolerance
signaling for the activation of Trx (22% increase) which suppresses the ASK1 expression thereby promoting the cell survival
that leads to the maintenance of the cellular homeostasis. 相似文献
137.
Erik Eckhert Padmini Rangamani Annie?E. Davis George Oster James?E. Berleman 《Biophysical journal》2014,107(11):2700-2711
Myxococcus xanthus is a Gram-negative, soil-dwelling bacterium that glides on surfaces, reversing direction approximately once every 6 min. Motility in M. xanthus is governed by the Che-like Frz pathway and the Ras-like Mgl pathway, which together cause the cell to oscillate back and forth. Previously, Igoshin et al. (2004) suggested that the cellular oscillations are caused by cyclic changes in concentration of active Frz proteins that govern motility. In this study, we present a computational model that integrates both the Frz and Mgl pathways, and whose downstream components can be read as motor activity governing cellular reversals. This model faithfully reproduces wildtype and mutant behaviors by simulating individual protein knockouts. In addition, the model can be used to examine the impact of contact stimuli on cellular reversals. The basic model construction relies on the presence of two nested feedback circuits, which prompted us to reexamine the behavior of M. xanthus cells. We performed experiments to test the model, and this cell analysis challenges previous assumptions of 30 to 60 min reversal periods in frzCD, frzF, frzE, and frzZ mutants. We demonstrate that this average reversal period is an artifact of the method employed to record reversal data, and that in the absence of signal from the Frz pathway, Mgl components can occasionally reverse the cell near wildtype periodicity, but frz- cells are otherwise in a long nonoscillating state. 相似文献