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91.
Stimulation of free radical generation in human leukocytes by various agents including tumor necrosis factor is a calmodulin dependent process 总被引:1,自引:0,他引:1
U N Das M Padma P S Sagar G Ramesh R Koratkar 《Biochemical and biophysical research communications》1990,167(3):1030-1036
The mechanism(s) involved in the generation of free radicals in human leukocytes by phorbol myristate acetate (PMA), formyl-methionyl-leucyl-phenylalanine (FMP), lipopolysaccharide (LPS), arachidonic acid (AA), and recombinant-tumor necrosis factor-1-alpha (r-TNF-1 alpha) was investigated. Calmodulin antagonists, chlorpromazine and trifluoperazine, inhibited free radical generation in human leukocytes by these stimulants. Dexamethosone, an inhibitor of phospholipase A2, could also block free radical generation in human leukocytes induced by r-TNF 1 alpha. PMA, FMP, LPS and TNF can activate phospholipase A2 and induce the release of AA from the cell membrane lipid pool. AA induced free radical generation in human leukocytes can be inhibited by calmodulin antagonists. Hence, it is likely that calmodulin dependent events play a crucial role in the generation of free radicals by human leukocytes in response to various stimulants including TNF. 相似文献
92.
Jeffrey G. Scott Padma Sridhar Nannan Liu 《Archives of insect biochemistry and physiology》1996,31(3):313-323
Cytochrome P450tpr is a xenobiotic metabolizing P450 that is found in house flies (Musca domestica). To better understand the regulation of cytochrome P450tpr, the effects of 21 potential monooxygenase inducers were examined for their ability to induce total cytochromes P450 and cytochrome P450tpr levels in adult flies. Six compounds caused induction of total cytochromes P450 per mg protein in adult susceptible (CS) house flies: ethanol (1.6-fold), phenobarbital in food (1.5-fold) or water (1.5-fold), naphthalene (1.3-fold), DDT (1.3-fold), xanthotoxin (1.4-fold), and α-pinene (1.2-fold). Six compounds were found to be inducers of cytochrome P450tpr: piperonyl butoxide in food (1.9-fold), phenobarbital in food (1.4-fold) and water (3.4-fold), clofibrate (1.3-fold), xanthotoxin (1.3-fold), methohexital (1.3-fold), and isosafrole (1.3-fold). Comparison of our results with house fly P450 6A1 indicates that there are specific inducers for each of these individual P450s as well as compounds that induce both P450s. Total P450s were inducible by PB in CS house fly larvae, but not in LPR larvae. Immunoblotting revealed no detectable P450tpr in control or PB-treated larvae in either strain. Thus, although total P450s are inducible in the susceptible strain larvae, P450tpr does not appear to be normally present or inducible with PB in larvae of either strain. Northern blots of phenobarbital (in water) treated CS flies indicated that there was a 4.2-fold increase in the P450tpr (i.e., CYP6D1) mRNA levels over the untreated flies. In the multiresistant LPR strain there was no apparent induction of CYP6D1 mRNA by phenobarbital. Following phenobarbital induction, the level of CYP6D1 mRNA in the CS strain was about half of the level in the LPR strain. © 1996 Wiley-Liss, Inc. 相似文献
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Padma S. Vankar Jyoti Srivastava Krešimir Molčanov Biserka Kojic-Prodić 《Phytochemistry letters》2009,2(2):67-71
A new steroidal lactone of the Withanolide A series has been isolated from the supercritical fluid extract of Eucalyptus globulus L. (bark) as a major component (I) along with a known structurally similar steroidal lactone as minor component (II). The structural identification of the new lactone was accomplished by different spectroscopic techniques viz. 1H and 13C NMR, etc. The relative stereochemistry was unequivocally determined from the X-ray crystallography. 相似文献
95.
Subashini M. Devarajan Padma V. Sonavane Ganeshchandra S. Doble Mukesh 《Journal of molecular modeling》2011,17(5):1141-1147
Drug uptake by polymer was modeled using a molecular dynamics (MD) simulation technique. Three drugs—doxorubicin (water soluble),
silymarin (sparingly water soluble) and gliclazide (water insoluble)—and six polymers with varied functional groups—alginic
acid, sodium alginate, chitosan, Gantrez AN119 (methyl-vinyl–ether-co-malic acid based), Eudragit L100 and Eudragit RSPO (both
acrylic acid based)—were selected for the study. The structures were modeled and minimized using molecular mechanics force
field (MM+). MD simulation (Gromacs-forcefield, 300 ps, 300 K) of the drug in the vicinity of the polymer molecule in the
presence of water molecules was performed, and the interaction energy (IE) between them was calculated. This energy was evaluated
with respect to electric-dipole, van der Waals and hydrogen bond forces. A good linear correlation was observed between IE
and our own previous data on drug uptake* [R
2 = 0.65, Radj2 = 0.65,Rpre2 = 0.56, {\hbox{R}}_{\rm{adj}}^2 = 0.65,{\hbox{R}}_{\rm{pre}}^2 = 0.56, and a F ratio of 30.25, P < 0.001; Devarajan et al. (2005) J Biomed Nanotechnol 1:1–9]. Maximum drug uptake by the polymeric nanoparticles (NP) was
achieved in water as the solvent environment. Hydrophilic interaction between NP and water was inversely correlated with drug
uptake. The MD simulation method provides a reasonable approximation of drug uptake that will be useful in developing polymer-based
drug delivery systems. 相似文献
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Justin A. Ezekowitz Carl van Walraven Finlay A. McAlister Paul W. Armstrong Padma Kaul 《CMAJ》2005,172(2):189-194