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991.
Jorge?A.?Falcón-Lezama Ruth?A.?Martínez-Vega Pablo?A.?Kuri-Morales José?Ramos-Casta?eda Ben?AdamsEmail author 《Bulletin of mathematical biology》2016,78(10):2011-2033
Dengue is a growing public health problem in tropical and subtropical cities. It is transmitted by mosquitoes, and the main strategy for epidemic prevention and control is insecticide fumigation. Effective management is, however, proving elusive. People’s day-to-day movement about the city is believed to be an important factor in the epidemiological dynamics. We use a simple model to examine the fundamental roles of broad demographic and spatial structures in epidemic initiation, growth and control. We show that the key factors are local dilution, characterised by the vector–host ratio, and spatial connectivity, characterised by the extent of habitually variable movement patterns. Epidemic risk in the population is driven by the demographic groups that frequent the areas with the highest vector–host ratio, even if they only spend some of their time there. Synchronisation of epidemic trajectories in different demographic groups is governed by the vector–host ratios to which they are exposed and the strength of connectivity. Strategies for epidemic prevention and management may be made more effective if they take into account the fluctuating landscape of transmission intensity associated with spatial heterogeneity in the vector–host ratio and people’s day-to-day movement patterns. 相似文献
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Luis García-García Ahmed Anis Shiha Pablo Bascuñana Javier de Cristóbal Rubén Fernández de la Rosa Mercedes Delgado Miguel A. Pozo 《Cellular and molecular neurobiology》2016,36(4):513-519
It has been reported that fluoxetine, a selective serotonin (5-hydroxytryptamine; 5-HT) reuptake inhibitor, has neuroprotective properties in the lithium–pilocarpine model of status epilepticus (SE) in rats. The aim of the present study was to investigate the effect of 5-HT depletion by short-term administration of p-chlorophenylalanine (PCPA), a specific tryptophan hydroxylase inhibitor, on the brain hypometabolism and neurodegeneration induced in the acute phase of this SE model. Our results show that 5-HT depletion did modify neither the brain basal metabolic activity nor the lithium–pilocarpine-induced hypometabolism when evaluated 3 days after the insult. In addition, hippocampal neurodegeneration and astrogliosis triggered by lithium–pilocarpine were not exacerbated by PCPA treatment. These findings point out that in the early latent phase of epileptogenesis, non-5-HT-mediated actions may contribute, at least in some extent, to the neuroprotective effects of fluoxetine in this model of SE. 相似文献
993.
Darren R. Brenner Paul Brennan Paolo Boffetta Christopher I. Amos Margaret R. Spitz Chu Chen Gary Goodman Joachim Heinrich Heike Bickeböller Albert Rosenberger Angela Risch Thomas Muley John R. McLaughlin Simone Benhamou Christine Bouchardy Juan Pablo Lewinger John S. Witte Gary Chen Shelley Bull Rayjean J. Hung 《Human genetics》2016,135(8):963-963
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Olaya Mediavilla Jaime Olaizola Luis Santos-del-Blanco Juan Andrés Oria-de-Rueda Pablo Martín-Pinto 《Mycorrhiza》2016,26(2):161-168
Boletus edulis Bull. is one of the most economically and gastronomically valuable fungi worldwide. Sporocarp production normally occurs when symbiotically associated with a number of tree species in stands over 40 years old, but it has also been reported in 3-year-old Cistus ladanifer L. shrubs. Efforts toward the domestication of B. edulis have thus focused on successfully generating C. ladanifer seedlings associated with B. edulis under controlled conditions. Microorganisms have an important role mediating mycorrhizal symbiosis, such as some bacteria species which enhance mycorrhiza formation (mycorrhiza helper bacteria). Thus, in this study, we explored the effect that mycorrhiza helper bacteria have on the efficiency and intensity of the ectomycorrhizal symbiosis between C. ladanifer and B. edulis. The aim of this work was to optimize an in vitro protocol for the mycorrhizal synthesis of B. edulis with C. ladanifer by testing the effects of fungal culture time and coinoculation with the helper bacteria Pseudomonas fluorescens Migula. The results confirmed successful mycorrhizal synthesis between C. ladanifer and B. edulis. Coinoculation of B. edulis with P. fluorescens doubled within-plant mycorrhization levels although it did not result in an increased number of seedlings colonized with B. edulis mycorrhizae. B. edulis mycelium culture time also increased mycorrhization levels but not the presence of mycorrhizae. These findings bring us closer to controlled B. edulis sporocarp production in plantations. 相似文献
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Guilherme M. Zanghelini Henrique R. A. de Souza Junior Luiz Kulay Edivan Cherubini Paulo T. Ribeiro Sebastião R. Soares 《The International Journal of Life Cycle Assessment》2016,21(12):1759-1775
Purpose
We bibliometrically evaluated the scientific literature outlined around Brazilian life cycle assessment (LCA). Our aim is twofold: (1) Analyze the Brazilian scientific literature on LCA, forming a current view of how the LCA methodology is applied in the country; (2) within this view, trace the evolution of themes, characterize institution collaboration, and indicate major influences in Brazilian LCA community.Methods
Data were outlined around academic production and publications, from 1993 to 2015, indexed by the Institute for Scientific Information (ISI- SCIE and SSCI) through a specific group of keywords. Initially, a temporal evolution and projection of papers, PhD and Master Theses, were performed. In sequence, indexed papers were analyzed through performance indicators (i.e., number of authors, impact factor, among others) and content evaluation (for instance, major addressed themes). Finally, a mapping of science was performed, with the aid of Cite Space software application, where coword (and evolution), cocollaboration (and evolution), and cocitation maps were created.Results and discussion
The survey identified 429 documents divided among international and national papers, PhD and Master Theses. From those documents, 165 were indexed. In terms of production and performance, the results indicate an undeniable evolution of the Brazilian LCA research, as affirmed by relations solidified through time. The main research field is “LCA application” with 84 % of papers, whereas “LCA methodology” completes the framework. In LCA applications, 25 % of publications are related to Biofuels—divided into bioethanol and biodiesel—which makes it the current dominant LCA research area in Brazil. The collaboration network demonstrates three main institution groups, whereas evolution through the years indicates that this situation may further improve. Influential authors are linked to LCA of biofuels, general LCA guidelines, and methodological LCA developments.Conclusions
Brazilian LCA research has been growing and more complex relations between themes and institutions denote that further developments can be expected. Cocollaboration indicates three main clusters, led by USP, Unicamp, and UFRJ. “Biofuels” is the main research area where sugarcane ethanol and biodiesel from different sources are the domain product systems. Cocitation analysis solidifies this statement, pointing to Isaias Macedo (and other biofuel researchers) as the main author in Brazilian LCA after ISO and Mark Goedkoop.998.
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