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21.
Sabaté M Giessen Wv Deshpande N Ligthart J Kay I Bruining N Serruys P 《International journal of cardiovascular interventions》1999,2(1):55-59
We report a patient who received a stent following intracoronary 3-irradiation. Despite a good initial angiographic result, the stent appeared to be not fully expanded on intravascular ultrasound imaging at 6-month follow-up. Four months later, sudden thrombotic occlusion occurred shortly after aspirin cessation. 相似文献
22.
The chaetognaths, or arrowworms, constitute a small and enigmatic phylum of
marine invertebrates whose phylogenetic affinities have long been
uncertain. A popular hypothesis is that the chaetognaths are the sister
group of the major deuterostome phyla: chordates, hemichordates, and
echinoderms. Here we attempt to determine the affinities of the
chaetognaths by using molecular sequence data. We describe the isolation
and nucleotide sequence determination of 18S ribosomal DNA from one species
of chaetognath and one acanthocephalan. Extensive phylogenetic analyses
employing a suite of phylogenetic reconstruction methods (maximum
parsimony, maximum likelihood, evolutionary parsimony, and two distance
methods) suggest that the hypothesized relationship between chaetognaths
and the deuterostomes is incorrect. In contrast, we propose that the
lineage leading to the chaetognaths arose prior to the advent of the
coelomate metazoa.
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23.
SCA8 RAN polySer protein preferentially accumulates in white matter regions and is regulated by eIF3F
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Hannah K Shorrock Tao Zu Monica Banez‐Coronel Tammy Reid Hirokazu Furuya H Brent Clark Juan C Troncoso Christopher A Ross SH Subramony Tetsuo Ashizawa Eric T Wang Anthony T Yachnis Laura PW Ranum 《The EMBO journal》2018,37(19)
Spinocerebellar ataxia type 8 (SCA8) is caused by a bidirectionally transcribed CTG·CAG expansion that results in the in vivo accumulation of CUG RNA foci, an ATG‐initiated polyGln and a polyAla protein expressed by repeat‐associated non‐ATG (RAN) translation. Although RAN proteins have been reported in a growing number of diseases, the mechanisms and role of RAN translation in disease are poorly understood. We report a novel toxic SCA8 polySer protein which accumulates in white matter (WM) regions as aggregates that increase with age and disease severity. WM regions with polySer aggregates show demyelination and axonal degeneration in SCA8 human and mouse brains. Additionally, knockdown of the eukaryotic translation initiation factor eIF3F in cells reduces steady‐state levels of SCA8 polySer and other RAN proteins. Taken together, these data show polySer and WM abnormalities contribute to SCA8 and identify eIF3F as a novel modulator of RAN protein accumulation. 相似文献