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排序方式: 共有65条查询结果,搜索用时 62 毫秒
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VIKRAM PATEL MARIO MAJ ALAN J. FLISHER MARY J. DE SILVA MIRJA KOSCHORKE MARTIN PRINCE WPA Zonal Member Society Representatives 《World psychiatry》2010,9(3):169-176
The treatment gap for people with mental disorders exceeds 50% in all countries
of the world, approaching astonishingly high rates of 90% in the least resourced
countries. We report the findings of the first systematic survey of leaders
of psychiatry in nearly 60 countries on the strategies for reducing the treatment
gap. We sought to elicit the views of these representatives on the roles of
different human resources and health care settings in delivering care and
on the importance of a range of strategies to increase the coverage of evidence-based
treatments for priority mental disorders for each demographic stage (childhood,
adolescence, adulthood and old age). Our findings clearly indicate three strategies
for reducing the treatment gap: increasing the numbers of psychiatrists and
other mental health professionals; increasing the involvement of a range of
appropriately trained non-specialist providers; and the active involvement
of people affected by mental disorders. This is true for both high income
and low/middle income countries, though relatively of more importance in the
latter. We view this survey as a critically important first step in ascertaining
the position of psychiatrists, one of the most influential stakeholder communities
in global mental health, in addressing the global challenge of scaling up
mental health services to reduce the treatment gap. 相似文献
43.
LYNNE M. MULLEN RACHEL J. HIRSCHMANN KELLY L. PRINCE TRAVIS C. GLENN MICHAEL J. DEWEY HOPI E. HOEKSTRA 《Molecular ecology resources》2006,6(1):36-40
We isolated and characterized 60 novel microsatellite markers from the closely related oldfield mouse (Peromyscus polionotus) and deer mouse (Peromyscus maniculatus) for studies of conservation, ecological, quantitative and population genetics. We assessed all 60 markers in a wild population of Peromyscus polionotus rhoadsi (N = 20) from central Florida and found an average of nine alleles per marker and an observed heterozygosity (HO) of 0.66 (range = 0.00–1.00). These polymorphic markers contribute to the growing number of genomic resources for Peromyscus, an emerging model system for ecological and evolutionary research. 相似文献
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Electron microscope studies of eight different sublines of Ehrlich ascites tumor cells which had not, as far as could be determined, come in contact with any known virus, revealed dense particles measuring approximately 55 to 70 mmicro in diameter, both within and attached to the wall of cytoplasmic vesicles identified as the endoplasmic reticulum. All tumor sublines contained significant numbers of particles and revealed no qualitative or quantitative differences in particle morphology or distribution. It is concluded that these structures are a constant morphological component of the Ehrlich ascites tumor and that they probably do not represent contaminating virus. Their morphology and distribution are described, and the possible interpretations of their significance are discussed. 相似文献
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MATSUMOTO JIRO; LYNCH THOMAS J.; GRABOWSKI SUSAN; RICHARDS CHRISTINA M.; LO SZECHENG L.; CLARK CARL; KERN DALE; TAYLOR JOHN D.; TCHEN T.T.; ISHIKAWA TAKATOSHI; MASAHITO PRINCE; TAKAYAMA SHOZO 《Integrative and comparative biology》1983,23(3):569-580
The objectives of this paper are to describe 1) the developmentof new research systems for biochemical comparison of cellulartraits between normal and tumorous pigment cells of fish origin,2) the similarity and dissimilarity between these two categoriesof pigment cells with regard to growth, differentiation andpigment translocating activities and 3) the potentials of thesetumorous pigment cells to manifest multiple differentiation.The development of research systems has been achieved by theestablishment of 1) methods to obtain homogenous populationsof viable, cultivatable xanthophores (erythrophores) and melanophoresfrom goldfish skins, 2) permanent cell lines from goldfish erythrophoromas(tumors derived from erythrophores) and from Nibe croaker irido-melanophoromas(tumors composed of mixed populations of iridophore- and melanophore-likecells) and 3) procedures to induce differentiation in normaland tumorous stem cells (including the formation of pigmentsand ability to undergo pigment translocation in response tocAMP, to the neurotransmitter epinephrine and to the hormonesACTH and melatonin). Two kinds of tumorous pigment cell linesexamined herein have the ability to form, in addition to variouspigments, structures similar to dermal skeletons and lentoidbodies. These findings strongly suggest the possibility thatthese fish pigment cell tumors are neural crest stem cell tumorsin nature. 相似文献
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