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Dorai Deepa Shanta Achanta Jyoti Jaju Koteswara Rao Rani Samyukta Mareli Claassens Ajay M. V. Kumar Vishnu PH 《PloS one》2013,8(10)
Background
Multi drug resistant and rifampicin resistant TB patients in India are treated with the World Health Organization (WHO) recommended standardized treatment regimens but no guidelines are available for the management of isoniazid (INH) resistant TB patients. There have been concerns that the standard eight-month retreatment regimen being used in India (2H3R3Z3E3S3/1H3R3Z3E3/5H3R3E3; H-Isoniazid; R-Rifampicin; Z-Pyrazinamide; E-Ethambutol; S-Streptomycin) may be inadequate to treat INH resistant TB cases and leads to poor treatment outcomes. We aimed to assess if INH resistance is associated with unfavorable treatment outcomes (death, default, failure and transferred out) among a cohort of smear positive retreatment TB patients registered in three districts of Andhra Pradesh, India.Methods
We conducted a retrospective record review of all smear positive retreatment TB patients without rifampicin resistance registered during April–December 2011.Results
Of 1,947 TB patients, 1,127 (58%) were tested with LPA—50 (4%) were rifampicin resistant, 933 (84%) were sensitive to INH and rifampicin and 144 (12%) were INH resistant. Of 144 INH resistant cases, 64 (44%) had poor treatment outcomes (25 (17%) default, 22 (15%) death, 12 (8%) failure and 5 (3%) transfer out) as compared to 287 (31%) among INH sensitive cases [aRR 1.46; 95%CI (1.19–1.78)].Conclusion
Our study confirms that INH resistance is independently associated with unfavorable treatment outcomes among smear positive retreatment TB patients, indicating that the current treatment regimen may be inadequate. These findings call for an urgent need for randomized controlled trials to discover the most effective treatment regimen for managing INH resistant TB. 相似文献109.
PH Skelton 《African Journal of Aquatic Science》2016,41(3):345-351
Changes made to the scientific names of southern African freshwater fishes since 2001 are explained and discussed. Adjustments to the phylogeny and classification of the fauna are outlined. Recent systematic studies on cyprinines are discussed and changes to the genera Labeobarbus (expanded concept), Pseudobarbus (expanded concept), and Enteromius are supported. The introduction of the family names Alestidae and Nothobranchiidae is discussed. Adjustments made to the genera Nannocharax, Micropanchax, Tilapia, Coptodon and Mastacembelus are explained. Species name changes for Hepsetus and Zaireichthys are detailed. New species described from the region, or resurrected from synonymy, since 2001 are listed. 相似文献
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