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171.
Ziqian Liang Ronald PC Wong Lin Hong Li Hesheng Jiang Hao Xiao Gang Li 《Proteome science》2008,6(1):2
Background
Trimethylation of the Nε-lysine residues in a protein is one of the most important events of posttranslational modifications. Simple methods for rapid detection and isolation of the Nε-trimethylated protein species are needed. This report introduces a novel method to prepare the affinity purified antibody specific for the Nε-trimethylated lysine (tMeK). The applications of the purified antibody are also reported in this paper. 相似文献172.
SC Voss Z Nikolovski PC Bourdon M Alsayrafi YO Schumacher 《Biology of sport / Institute of Sport》2016,33(1):23-28
Leptin and adiponectin play an essential role in energy metabolism. Leptin has also been proposed as a marker for monitoring training load. So far, no studies have investigated the variability of these hormones in athletes and how they are regulated during cumulative exercise. This study monitored leptin and adiponectin in 15 endurance athletes twice daily in the days before, during and after a 9-day simulated cycling stage race. Adiponectin significantly increased during the race (p = 0.001) and recovery periods (p = 0.002) when compared to the baseline, while leptin decreased significantly during the race (p < 0.0001) and returned to baseline levels during the recovery period. Intra-individual variability was substantially lower than inter-individual variability for both hormones (leptin 34.1 vs. 53.5%, adiponectin 19% vs. 37.2%). With regards to exercise, this study demonstrated that with sufficient, sustained energy expenditure, leptin concentrations can decrease within the first 24 hours. Under the investigated conditions there also appears to be an optimal leptin concentration which ensures stable energy homeostasis, as there was no significant decrease over the subsequent race days. In healthy endurance athletes the recovery of leptin takes 48-72 hours and may even show a supercompensation-like effect. For adiponectin, significant increases were observed within 5 days of commencing racing, with these elevated values failing to return to baseline levels after 3 days of recovery. Additionally, when using leptin and adiponectin to monitor training loads, establishing individual threshold values improves their sensitivity. 相似文献
173.
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174.
Abstract: Recent clinical evidence has suggested that interferon-β is efficacious in the treatment of the demyelinating disease, multiple sclerosis. The mechanism of its efficacy remains unclear, and suggested modes of action have focused on immune modulation. Nonimmune effects of interferon-β may also contribute to its efficacy. Given that astrocytes produce a range of neurotrophic factors, we examined the possibility that interferon-β could increase the astrocytic production of nerve growth factor (NGF), which has been reported to cause oligodendrocytes to proliferate and to extend their processes; these phenotypes can impact favorably on remyelination. When the recombinant form of mouse interferon-β was added to mouse astrocyte cultures, a dose-dependent increase in NGF mRNA was obtained. The 40-fold increase in NGF mRNA elicited by 1,000 U/ml interferon-β was far more potent than that produced by other NGF-elevating agents in this study. In concordance, the protein for NGF was elevated by interferon-β. The production of NGF by interferon-β may be relevant to its clinical efficacy in multiple sclerosis. Furthermore, we suggest the potential utility of interferon-β in Alzheimer's disease. 相似文献
175.
Donato Inverso Jingjing Shi Ki Hong Lee Moritz Jakab Shani Ben-Moshe Shubhada R. Kulkarni Martin Schneider Guanxiong Wang Marziyeh Komeili Paula Argos Vélez Maria Riedel Carleen Spegg Thomas Ruppert Christine Schaeffer-Reiss Dominic Helm Indrabahadur Singh Michael Boutros Sudhakar Chintharlapalli Hellmut G. Augustin 《Developmental cell》2021,56(11):1677-1693.e10
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176.
177.
Blocking airflow through half of the nasal cavity during early life results
in a 25% reduction in the size of the ipsilateral main olfactory bulb. The
present study indicates that the size of the accessory bulb is relatively
unaffected by the procedure.
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