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81.
Nuclear DNA sequences from late Pleistocene megafauna 总被引:6,自引:1,他引:5
We report the retrieval and characterization of multi- and single-copy
nuclear DNA sequences from Alaskan and Siberian mammoths (Mammuthus
primigenius). In addition, a nuclear copy of a mitochondrial gene was
recovered. Furthermore, a 13,000-year-old ground sloth and a 33,000-
year-old cave bear yielded multicopy nuclear DNA sequences. Thus, multicopy
and single-copy genes can be analyzed from Pleistocene faunal remains. The
results also show that under some circumstances, nucleotide sequence
differences between alleles found within one individual can be
distinguished from DNA sequence variation caused by postmortem DNA damage.
The nuclear sequences retrieved from the mammoths suggest that mammoths
were more similar to Asian elephants than to African elephants.
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82.
Sefa Celik Ali Tugrul Albayrak Sevim Akyuz Aysen E. Ozel 《Journal of biomolecular structure & dynamics》2020,38(5):1354-1364
AbstractA new ionic liquid was synthesized by the reaction of caprolactam with salicylic acid (CL-SA) and characterized by analysis of spectroscopic and DSC data. The optimized geometry and the electrostatic potential map of CL-SA were calculated with DFT method using the wb97xd/6-31++G(d,p) level of theory. Molecular docking study of the CL-SA was carried out to clarify the probable binding modes between the title compound and DNA and COX-2 and TOPII enzymes. In silico ADMET study was also performed for predicting pharmacokinetic and toxicity profile of the synthesized ionic liquid which expressed good oral drug-like behavior and non-toxic nature. It was revealed that the compound has a potential to become a lead molecule in drug discovery process.Communicated by Ramaswamy H. Sarma 相似文献