排序方式: 共有254条查询结果,搜索用时 906 毫秒
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Jürgen Dengler Thomas J. Matthews Manuel J. Steinbauer Sebastian Wolfrum Steffen Boch Alessandro Chiarucci Timo Conradi Iwona Dembicz Corrado Marcenò Itziar García-Mijangos Arkadiusz Nowak David Storch Werner Ulrich Juan Antonio Campos Laura Cancellieri Marta Carboni Giampiero Ciaschetti Pieter De Frenne Jiri Dolezal Christian Dolnik Franz Essl Edy Fantinato Goffredo Filibeck John-Arvid Grytnes Riccardo Guarino Behlül Güler Monika Janišová Ewelina Klichowska Łukasz Kozub Anna Kuzemko Michael Manthey Anne Mimet Alireza Naqinezhad Christian Pedersen Robert K. Peet Vincent Pellissier Remigiusz Pielech Giovanna Potenza Leonardo Rosati Massimo Terzi Orsolya Valkó Denys Vynokurov Hannah White Manuela Winkler Idoia Biurrun 《Journal of Biogeography》2020,47(1):72-86
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Sándor Spisák Norbert Solymosi Péter Ittzés András Bodor Dániel Kondor Gábor Vattay Barbara K. Barták Ferenc Sipos Orsolya Galamb Zsolt Tulassay Zoltán Szállási Simon Rasmussen Thomas Sicheritz-Ponten S?ren Brunak Béla Molnár István Csabai 《PloS one》2013,8(7)
Our bloodstream is considered to be an environment well separated from the outside world and the digestive tract. According to the standard paradigm large macromolecules consumed with food cannot pass directly to the circulatory system. During digestion proteins and DNA are thought to be degraded into small constituents, amino acids and nucleic acids, respectively, and then absorbed by a complex active process and distributed to various parts of the body through the circulation system. Here, based on the analysis of over 1000 human samples from four independent studies, we report evidence that meal-derived DNA fragments which are large enough to carry complete genes can avoid degradation and through an unknown mechanism enter the human circulation system. In one of the blood samples the relative concentration of plant DNA is higher than the human DNA. The plant DNA concentration shows a surprisingly precise log-normal distribution in the plasma samples while non-plasma (cord blood) control sample was found to be free of plant DNA. 相似文献
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János Kerékgyártó László Kalmár Zoltán Szurmai Orsolya Hegyi Gábor K. Tóth 《International journal of peptide research and therapeutics》2012,18(1):1-5
Electron-donating O-benzylated glycosylamine mono-, di- and trisaccharide representing the reducing terminal of the core structure of N-glycans were incorporated, in anomerically pure from into Leu–Lys–Asn–Gly-Gly–Pro hexapeptide that is a partial structure
of the Trp-cage mini-protein by convergent assembly. According to our results acylation of electron-donating O-benzylated glycosylamine with peptide acid under the proposed new reaction conditions led to the formation of glycopeptide
in good yield and in anomerically pure form for the first time. This convergent approach allows the synthesis of a series
of glycopeptides containing different oligosaccharides without the need to resynthesize the peptide for each individual case. 相似文献
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Gbor Mdra Istvn Mak dm Lrincz Orsolya Juhsz Pter Jnos Kiss Gbor Lrinczi 《Ecology and evolution》2020,10(24):13787
In the genus Aphaenogaster, workers use tools to transport liquid food to the colony. During this behavior, ants place or drop various kinds of debris into liquids or soft food, and then, they carry the food‐soaked tools back to the nest. According to some authors, this behavior is not "true" tool use because it represents two separate processes: a defense response to cover the dangerous liquid and a transport of food. Here, we investigated the debris dropping and retrieving behavior of the ant Aphaenogaster subterranea to establish which of the two hypotheses is more probable by conducting manipulative experiments. We tested the responses of eight colonies (a) to liquid food (honey‐water) and nonfood liquids (water) in different distances from the nest and (b) to nonthreatening liquids previously covered or presented as small droplets. We also tested whether the nutritional condition of colonies (i.e., starved or satiated) would affect the intensity and rate of debris dropping. Our results were consistent with the tool‐using behavior hypothesis. Firstly, ants clearly differentiated between honey‐water and water, and they directed more of their foraging effort toward liquids farther from the nest. Secondly, ants performed object dropping even into liquids that did not pose the danger of drowning or becoming entangled. Lastly, the nutritional condition of colonies had a significant effect on the intensity and rate of object dropping, but in the opposite direction than we expected. Our results suggest that the foraging behavior of A. subterranea is more complex than that predicted by the two‐component behavior hypothesis and deserves to be considered as "true" tool use. 相似文献
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Dancing is a popular form of physical exercise and studies have show that dancing can decrease anxiety, increase self-esteem, and improve psychological wellbeing. The aim of the current study was to explore the motivational basis of recreational social dancing and develop a new psychometric instrument to assess dancing motivation. The sample comprised 447 salsa and/or ballroom dancers (68% female; mean age 32.8 years) who completed an online survey. Eight motivational factors were identified via exploratory factor analysis and comprise a new Dance Motivation Inventory: Fitness, Mood Enhancement, Intimacy, Socialising, Trance, Mastery, Self-confidence and Escapism. Mood Enhancement was the strongest motivational factor for both males and females, although motives differed according to gender. Dancing intensity was predicted by three motivational factors: Mood Enhancement, Socialising, and Escapism. The eight dimensions identified cover possible motives for social recreational dancing, and the DMI proved to be a suitable measurement tool to assess these motives. The explored motives such as Mood Enhancement, Socialising and Escapism appear to be similar to those identified in other forms of behaviour such as drinking alcohol, exercise, gambling, and gaming. 相似文献
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Katalin Leiszter Ferenc Sipos Orsolya Galamb Tibor Krenács Gábor Veres Barna Wichmann István F?ri Alexandra Kalmár árpád V. Patai Kinga Tóth Gábor Valcz Zsolt Tulassay Béla Molnár 《PloS one》2015,10(2)
BackgroundSomatostatin (SST) has anti-proliferative and pro-apoptotic effects. Our aims were to analyze and compare the SST expression during normal aging and colorectal carcinogenesis at mRNA and protein levels. Furthermore, we tested the methylation status of SST in biopsy samples, and the cell growth inhibitory effect of the SST analogue octreotide in human colorectal adenocarcinoma cell line.MethodsColonic samples were collected from healthy children (n1 = 6), healthy adults (n2 = 41) and colorectal cancer patients (CRCs) (n3 = 34) for SST mRNA expression analysis, using HGU133 Plus2.0 microarrays. Results were validated both on original (n1 = 6; n2 = 6; n3 = 6) and independent samples ((n1 = 6; n2 = 6; n3 = 6) by real-time PCR. SST expressing cells were detected by immunohistochemistry on colonic biopsy samples (n1 = 14; n2 = 20; n3 = 23). The effect of octreotide on cell growth was tested on Caco-2 cell line. SST methylation percentage in biopsy samples (n1 = 5; n2 = 5; n3 = 9) was defined using methylation-sensitive restriction enzyme digestion.ResultsIn case of normal aging SST mRNA expression did not alter, but decreased in cancer (p<0.05). The ratio of SST immunoreactive cells was significantly higher in children (0.70%±0.79%) compared to CRC (0%±0%) (p<0.05). Octreotide significantly increased the proportion of apoptotic Caco-2 cells. SST showed significantly higher methylation level in tumor samples (30.2%±11.6%) compared to healthy young individuals (3.5%±1.9%) (p<0.05).ConclusionsIn cancerous colonic mucosa the reduced SST production may contribute to the uncontrolled cell proliferation. Our observation that in colon cancer cells octreotide significantly enhanced cell death and attenuated cell proliferation suggests that SST may act as a regulator of epithelial cell kinetics. The inhibition of SST expression in CRC can be epigenetically regulated by promoter hypermethylation. 相似文献