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201.
Larina I. M. Brzhzovsky A. G. Nosovsky A. M. Indeykina M. I. Kononikhin A. S. Nikolaev E. N. Orlov O. I. 《Human physiology》2021,47(4):438-447
Human Physiology - Oxidative damage to main cell components (DNA, lipids, and proteins) in the human body during a spaceflight (SF) is more intense than in normal conditions because of the... 相似文献
202.
Doklady Biological Sciences - Electrical discharges (EDs) in the African sharptooth catfish Clarias gariepinus were studied. Irregular monopolar EDs, lasting for 8–10 ms and longer, and more... 相似文献
203.
Lustig Adi Margi Raz Orlov Aleksei Orlova Daria Azaria Liran Gefen Amit 《Biomechanics and modeling in mechanobiology》2021,20(3):851-860
Biomechanics and Modeling in Mechanobiology - Pressure ulcers are localized sites of tissue damage which form due to the continuous exposure of skin and underlying soft tissues to sustained... 相似文献
204.
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206.
V. V. Tikhonov D. S. Orlov O. V. Lisovitskaya Yu. A. Zavgorodnyaya B. A. Byzov V. V. Demin 《Microbiology》2013,82(6):707-712
Capacity for sorption of humic acid (HA) from water solutions was shown for 38 bacterial strains. Isotherms of HA sorption were determined for the cells of 10 strains. The bonding strength between the cells and HA (k) and the terminal adsorption (Q max) determined from the Langmuir equation for gram-positive and gram-negative bacteria were reliably different. Gram-positive bacteria sorbed greater amounts of HA than gram-negative ones (Q max = 23 ± 10 and 5.6 ± 1.2 mg/m2, respectively). The bonding strength between HA and the cells was higher in gram-negative bacteria than in gram-positive: k = 9 ± 5 and 3.3 ± 1.1 mL/mg, respectively. 相似文献
207.
O. L. Vinogradova D. V. Popov A. I. Netreba D. V. Tsvirkun N. S. Kurochkina A. V. Bachinin Ya. R. Bravyi E. V. Lyubaeva E. A. Lysenko T. F. Miller A. S. Borovik O. S. Tarasova O. I. Orlov 《Human physiology》2013,39(5):511-523
The hypertrophic effect of strength training is known to be due to mechanical and metabolic stimuli. During exercises with the restricted blood supply of working muscles, i.e., under the conditions of intensified metabolic stress, the training effect may be achieved with much lower external loads (20% of one repetition maximum). The effects of 8 weeks of high-intensity (80–85% of one repetition maximum) strength training were compared to low-intensity (50% of one repetition maximum) training without relaxation. The high-intensity strength training resulted in higher increases in strength and size of the exercised muscles than training without relaxation. During high-intensity training, at the muscle cross section, an increase in the area occupied by type II fibers prevails; while, during training without relaxation, an increase in the area occupied by type I fibers prevails. An exercise session without relaxation leads to a more pronounced increase in the secretion of the growth hormone, insulin-like growth factor-1, and cortisol. The expression of gene regulating myogenesis (Myostatin) is changed in different ways after a high-intensity strength exercise session and after an exercise session without relaxation. Low-intensity strength training (50% of one repetition maximum) without relaxation is an efficient way for inducing increases of the strength and size of the trained muscles. This low-intensive type of training may be used in rehabilitation medicine, sports, and fitness. 相似文献
208.
Although the interactions between bilirubin and serum albumin are among the most studied serum albumin-ligand interactions, the binding-site location and the participation of bilirubin-serum albumin complexes in pathological and physiological processes are under debate. In this article, we have benefited from the chiral structure of bilirubin and used CD spectroscopy to characterize the structure of bilirubin bound to human and bovine serum albumins. We determined that in a phosphate buffer at pH 7.8 there are three binding sites in both human and bovine serum albumins. While the primary binding sites in human and bovine serum albumins bind bilirubin with P- and M-helical conformations, respectively, the secondary binding sites in both albumins bind bilirubin in the P-helical conformation. We have shown that the bonding of bilirubin to the serum albumin matrix is a more favorable process than the self-association of bilirubin under the studied conditions, with a maximum of three bound bilirubins per serum albumin molecule. Although bilirubin bound to the primary binding site has attracted the most attention, the presented results have documented the impact of the secondary binding sites which are relevant in the displacement reactions between BR and drugs and in the phenomena where bilirubin plays antioxidant, antimutagenic, and anti-inflammatory roles. Chirality 00:000000, 2013. © 2013 Wiley Periodicals, Inc. 相似文献
209.
Systems Biology involves the study of the interactions of biological systems and ultimately their functions. Down''s syndrome (DS)
is one of the most common genetic disorders which are caused by complete, or occasionally partial, triplication of chromosome 21,
characterized by cognitive and language dysfunction coupled with sensory and neuromotor deficits. Neural Tube Disorders
(NTDs) are a group of congenital malformations of the central nervous system and neighboring structures related to defective
neural tube closure during the first trimester of pregnancy usually occurring between days 18-29 of gestation. Several studies in the
past have provided considerable evidence that abnormal folate and methyl metabolism are associated with onset of DS & NTDs.
There is a possible common etiological pathway for both NTDs and Down''s syndrome. But, various research studies over the years
have indicated very little evidence for familial link between the two disorders. Our research aimed at the gene expression profiling
of microarray datasets pertaining to the two disorders to identify genes whose expression levels are significantly altered in these
conditions. The genes which were 1.5 fold unregulated and having a p-value <0.05 were filtered out and gene interaction network
were constructed for both NTDs and DS. The top ranked dense clique for both the disorders were recognized and over
representation analysis was carried out for each of the constituent genes. The comprehensive manual analysis of these genes yields
a hypothetical understanding of the lack of familial link between DS and NTDs. There were no genes involved with folic acid
present in the dense cliques. Only – CBL, EGFR genes were commonly present, which makes the allelic variants of these genes –
good candidates for future studies regarding the familial link between DS and NTDs.
Abbreviations
NTD - Neural Tube Disorders, DS - Down''s Syndrome, MTHFR - Methylenetetrahydrofolate reductase, MTRR– 5 - methyltetrahydrofolate-homocysteine methyltransferase reductase. 相似文献210.
Stolbkov IuK Orlov IV 《Rossi?skii fiziologicheski? zhurnal imeni I.M. Sechenova / Rossi?skaia akademiia nauk》2011,97(3):292-301
Optokinetic stimulation with the angle velocity 10 degrees/s was carried out in pigeons in differently bent postures. No difference in effects of dynamic and static inclinations upon optokinetic and postoptokinetic nystagmus was found. Neither any rigid connection was found between the inclination direction and the sign of the response change. The data obtained are at variance with the hypothesis of gravity-dependent changes of the "velocity accumulator" time constant as the only cause of changes in the optokinetic and postoptokinetic responses under conditions of dynamic or static inclinations. 相似文献