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S N Orlov N I Pokudin J Postnov YuVKunes J Zicha 《Physiological research / Academia Scientiarum Bohemoslovaca》1991,40(1):7-10
The activity of Na+, K(+)-ATPase in SHR erythrocytes treated with saponin is increased by 30-40% as compared to the Brown Norway (BN.lx) strain whereas the activity of Ca(2+)-ATPase is decreased by 20-30%. Passive permeability of SHR erythrocytes determined by 86Rb influx is increased by 20-30%. In the presence of orthovanadate erythrocytes of SHR accumulate 45Ca by 80% more than BN.lx red cells. There was no difference in Na+/H+ exchange between erythrocytes of SHR and BN.lx animals. 相似文献
156.
The study on ceftriaxone penetration into bronchial secretion showed that in patients with a short-term history of chronic bronchitis (no more than 3 years) ceftriaxone used in a dose of 1 g once a day intramuscularly was detectable in the bronchial secretion within 10 hours after the administration, its concentrations being 0.67-2.41 micrograms/ml in 3 hours, 15.87 micrograms/ml in 4.5 hours, 4.58 micrograms/ml in 6.5 hours and 2.29 micrograms/ml in 10 hours. In patients with a long-term history of chronic bronchitis (mean 10 to 20 years) the presence of ceftriaxone in the bronchial secretion was detectable in a concentration of 0.51-3.75 micrograms/ml only in 2 hours after its administration. Beginning from the 5th hour after the administration its detection failed. This is indicative of lower ceftriaxone penetration into the bronchial secretion of such patients. The duration of chronic bronchitis did not influence ceftriaxone pharmacokinetics in blood. The contents of the antibiotic in serum and bronchial secretion were determined by HPLC (the resolving power of 0.5 micrograms/ml). 相似文献
157.
Iu V Kotelevtsev S N Orlov N I Pokudin V M Agnaev Iu V Postnov 《Biulleten' eksperimental'no? biologii i meditsiny》1987,103(4):456-458
Positive correlation between Na+, K+-cotransport speed values in platelets and arterial pressure (AP) medium values was disclosed in F2 murine hybrids with spontaneous hypertension (SHT) and in WKY controls as was the correlation between Ca erythrocytic levels and the value of delta AP-AP1-AP2, with AP1--systolic AP measured in alert animals, AP2--medium AP measured directly in anesthetized rats. The data obtained during the aforementioned experimental series together with those obtained in the premorbid stage provided for a conclusion that all the signs considered were inherited in chain with a positive deposit in AP and played an important role in the pathogenesis of primary arterial hypertension. 相似文献
158.
N I Pokudin S N Orlov Iu V Postnov 《Biulleten' eksperimental'no? biologii i meditsiny》1987,104(10):416-418
The dependence of the rate of valinomycin-induced Na+/H+ erythrocyte metabolism on the extracellular K+ concentration has been investigated. It has been established that Na+/H+ metabolism in the erythrocytes of spontaneously hypertensive rats (SHR) is induced at higher [K+]o concentrations than in normotensive controls (WKY). The distinctions in the maximum rate of Na+/H+ metabolism were revealed only in SHR in pre-hypertensive stage (it was 20% lower than in WKY). It is suggested that the distinctions are determined by peculiarities of membrane cytoskeleton formation. The conclusion was confirmed in experiments on erythrocyte stability to orthovanadate effect. 相似文献
159.
Voropaeva E. N. Cherdyntseva N. V. Voevoda M. I. Pospelova T. I. Maximov V. N. Orlov Yu. L. Ageeva T. A. 《Russian Journal of Genetics》2019,55(12):1564-1568
Russian Journal of Genetics - The role of genetic susceptibility to the development of lymphoma is confirmed by the accumulating data on common genetic variants of the genes involved in... 相似文献
160.
The effect of the temporal structure of a vocal stimulus on the perception of the emotional component of the signal was studied in several age groups (7–10, 11–13, and 14–17 years). The experiments were performed at different durations of the stimulus (0.5, 1, 1.5, 2, and 3 s). ANOVA of the recognition efficiency and response time showed that the stimulus duration and the interactions of this factor with two others (stimulus duration × age and stimulus duration × emotion type) were highly significant for the recognition of emotions. The effects of the temporal structure of the signal on the recognition efficiency and response time were the strongest in the cases of neutral and negative emotional intonations and on going from the youngest to the middle age group. The minimal stimulus duration at which the threshold recognition of the emotion type occurred changed with age (from 2 s in the youngest age group to 0.5 s in the oldest). The capacity of the sensory acoustic memory was evaluated in children and adolescents of different ages. 相似文献