Triboluminescence of the blood in mice during immunization and the administration of thymic hormonal factors

Triboluminescence (TrL) is optical radiation, arising at the expense of energy of free radical oxidation (in mechanochemical influence) and electrophysical processes in the cell membranes of blood. Under the influence of immunization a decrease of cell membrane polarization is observed. Administration of thymic agents (vilosen and tactivin) into intact and immunized animals decreases the TrL intensity as well, that could be considered as manifestation of their antioxidant effects.     

Actin retrograde flow controls natural killer cell response by regulating the conformation state of SHP‐1

Natural killer (NK) cells are a powerful weapon against viral infections and tumor growth. Although the actin–myosin (actomyosin) cytoskeleton is crucial for a variety of cellular processes, the role of mechanotransduction, the conversion of actomyosin mechanical forces into signaling cascades, was never explored in NK cells. Here, we demonstrate that actomyosin retrograde flow (ARF) controls the immune response of primary human NK cells through a novel interaction between β‐actin and the SH2‐domain‐containing protein tyrosine phosphatase‐1 (SHP‐1), converting its conformation state, and thereby regulating NK cell cytotoxicity. Our results identify ARF as a master regulator of the NK cell immune response. Since actin dynamics occur in multiple cellular processes, this mechanism might also regulate the activity of SHP‐1 in additional cellular systems.     

Mechanoluminescence: An assay for lymphocyte analysis in neoplasia

We have studied the mechano-electrochemical activation of optical emission (mechanoluminescence, ML) from the surface of lymphocytes. In C57BL/6 mice with B16 melanoma at the terminal stage of tumour growth and after immunotherapy with thymic agents, there is a correlation between light emission and the value of lymphocyte surface charge and titres of thymic serum factor (FTS).     

The triboluminescence of the blood and the brain cellular elements in rats exposed to X irradiation in doses causing bone marrow, intestinal and cerebral syndromes]

Triboluminescence of blood and brain cells (neurons and neuroglia) in bone marrow, intestinal and cerebral radiation syndromes has been investigated. Dynamics of triboluminescence intensity of neurons and glial cells after irradiation (0.013, 0.31 and 3.87 C/kg) is the same with that of blood triboluminescence.