排序方式: 共有105条查询结果,搜索用时 0 毫秒
91.
92.
Effects of captopril and losartan on lipid peroxidation,protein oxidation and nitric oxide release in diabetic rat kidney 总被引:7,自引:0,他引:7
Yavuz D Küçükkaya B Haklar G Ersöz O Akoğlu E Akalin S 《Prostaglandins, leukotrienes, and essential fatty acids》2003,69(4):223-227
Increased oxidative stress has an important role in the pathogenesis of diabetic nephropathy. The aim of this study was to evaluate the effects of renin-anigiotensin system blockage, either by angiotensin-converting enzyme inhibition or angiotensin receptor blockage, on oxidative stress and nitric oxide release in diabetic rat kidneys. After induction of diabetes, six rats were given captopril, six rats were given losartan, and six rats served as diabetic controls. Six healthy rats were also included. At the end of an 8-week period nitric oxide release, lipid peroxidation and protein oxidation were measured in kidney cortices, and urinary albumin excretion (UAE) was determined in 24-h urine samples. Losartan- and captopril-treated diabetic rats had lower levels of UAE than diabetic controls. Diabetic rats had higher levels of lipid peroxidation and protein oxidation compared to healthy rats. NO release was significantly lower in diabetic groups than healthy controls. UAE levels showed a positive correlation with lipid peroxidation and a negative correlation with NO release. Inhibition of lipid peroxidation could be one of the protective mechanisms of renin-angiotensin axis inhibition in diabetic kidney tissues. 相似文献
93.
94.
Tombulturk Fatma Kubra Todurga-Seven Zeynep Gizem Huseyinbas Onder Ozyazgan Sibel Ulutin Turgut Kanigur-Sultuybek Gonul 《Molecular biology reports》2022,49(1):73-83
Molecular Biology Reports - Diabetic chronic wound, which is one of the diabetic complications caused by hyperglycemia, characterized by prolonged inflammation has become one of the most serious... 相似文献
95.
96.
97.
C. Q. Zou Y. Q. Zhang A. Rashid H. Ram E. Savasli R. Z. Arisoy I. Ortiz-Monasterio S. Simunji Z. H. Wang V. Sohu M. Hassan Y. Kaya O. Onder O. Lungu M. Yaqub Mujahid A. K. Joshi Y. Zelenskiy F. S. Zhang I. Cakmak 《Plant and Soil》2012,358(1-2):119-130
Background and aims
Phosphorus (P) is a commonly limiting nutrient for plant growth in natural environments. Many legumes capable of N2-fixation require more P than non-legumes do. Some legume crops can use sparingly soluble forms of P such as iron phosphate much better than other species, but reports on the ability of woody legumes to access iron phosphate are rare.Methods
Plants of four Acacia species (Acacia stipuligera F. Muell., A. ancistrocarpa Maiden & Blakely, A. stellaticeps Kodela, Tindale & D. Keith and A. robeorum Maslin), native to the Great Sandy Desert in north-western Australia, were grown in a glasshouse in river sand with different levels of iron phosphate, between 0 and 16?μg P g?1 sand. Plant growth, tissue P concentrations, and pH and carboxylates in the rhizosphere were measured.Results
Growth of A. stipuligera and A. ancistrocarpa was not responsive to increased P supply; in contrast, A. stellaticeps and A. robeorum produced significantly more root and shoot dry mass at 8 and 16?μg P g?1 sand than at 0?μg P g?1 sand; differences in root mass ratio were significant between species but not between P treatments. A. robeorum was the only species colonised by mycorrhizal fungi, and the colonisation percentage decreased with increasing P supply. In all species, P-uptake rates and tissue P concentrations were significantly higher at greater P supply. Rhizosphere pH and the amount of carboxylates in the rhizosphere decreased with increasing P supply.Conclusions
Net P uptake increased with increasing P supply, showing that the present Acacia species can access P from iron phosphate. However, due to their inherently slow growth rate, enhanced P supply did not increase growth of two of the four studied species. The ability of the Acacia species to access P from iron phosphate is presumably related with carboxylate exudation and rhizosphere acidification. 相似文献98.
Onder Duzlu Alparslan Yildirim Zuhal Onder Arif Ciloglu Gamze Yetismis Abdullah Inci 《The Journal of eukaryotic microbiology》2019,66(5):771-777
Microsporidia are opportunistic pathogens that infect a wide range of invertebrates and vertebrates. To assess the potential role of dogs in the transmission of these zoonotic pathogens, a total of 282 fecal samples from dogs in the Central Anatolia Region of Turkey were analyzed by utilizing species specific polymerase chain reaction for the four most frequent human microsporidia. Two microsporidia species were recognized in 41 samples (14.5%). Encephalitozoon intestinalis was detected in 35 samples (12.4%) and it was the most common microsporidium. The second microsporidium, E. cuniculi, was identified in six (2.1%) of the samples. Sequence analysis of the intergenic spacer of the ribosomal ribonucleic acid (RNA) internal transcribed spacer (ITS) gene revealed the presence of three E. intestinalis haplotypes closely associated with each other. No polymorphic region was found among the ITS sequences of E. cuniculi isolates and they were characterized as genotype III. This study provides the first data on the zoonotic microsporidia species from dogs in Turkey. 相似文献
99.
Quantitative evaluation of immunohistochemical staining in gastrointestinal stromal tumors 总被引:1,自引:0,他引:1
Ozcan A Karslioglu Y Kurt B Onguru O Gunhan O 《Analytical and quantitative cytology and histology / the International Academy of Cytology [and] American Society of Cytology》2007,29(3):159-165
OBJECTIVE: To evaluate the differences among pathologists' interpretations in gastrointestinal stromal tumors (GISTs) and to demonstrate the usefulness of quantitative pathology in the assessment of immunohistochemical staining. STUDY DESIGN: Twenty GISTs were separately evaluated by 4 pathologists by the visual estimation method using a 6-antibody panel. Each case was then quantitatively measured with a computer-assisted image analysis system by 2 pathologists. Cohen's kappa test was performed for statistical analysis. RESULTS: All GISTs showed some degree of expression of CD 117, CD34, SMA and Ki-67. No case was immunoreactive for desmin or S-100 protein. There were remarkable differences in the pathologists' visual estimations. Moreover, the discrepancies between visual and quantitative methods were noteworthy. The differences in interpretations showed the greatest variability for Ki-67, which is known to be related to poor prognosis. CONCLUSION: Quantitative pathology in assessment of immunohistochemical staining of GISTs may improve the consistency in the interpretation of staining results and provide some degree of reproducibility. 相似文献
100.
Stefanie L. De Buyser Mirko Petrovic Youri E. Taes Davide L. Vetrano Andrea Corsonello Stefano Volpato Graziano Onder 《PloS one》2014,9(5)