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排序方式: 共有221条查询结果,搜索用时 15 毫秒
31.
Unal R Pokrovskaya I Tripathi P Monia BP Kern PA Ranganathan G 《The Biochemical journal》2008,413(2):315-322
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Gamze Guney Eskiler Isil Ezgi Eryilmaz Beste Yurdacan Unal Egeli Gulsah Cecener Berrin Tunca 《Journal of biochemical and molecular toxicology》2019,33(8)
The aim of this study was to investigate the combined effects of usnic acid (UA) and Tamoxifen (Tam) or Enzalutamide (Enz) on hormone receptor‐positive breast and prostate cancer (BC and PC), respectively. The antiproliferative and apoptotic effects of Tam or Enz alone and in combination with UA on MCF7 and LNCaP cancer cells were detected. The results of the WST‐1 assay indicated that UA was a promising anticancer compound that significantly enhanced the effectiveness of hormone therapy drugs compared with each drug alone (combination index < 1). In addition, the combination of UA with Tam or Enz remarkably induced more cell cycle arrest at the G0/G1 phase and apoptosis than only drug‐treated cells (P < 0.01). Consequently, our findings suggest that the combination of UA with Tam or Enz may be a potential therapeutic approach for the treatment of BC and PC and further studies are required to exploit the potential mechanisms of synergistic effects. 相似文献
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Munir Ozturk Mert Metin Volkan Altay Tomonori Kawano Alvina Gul Bengu Turkyilmaz Unal Dilek Unal Rouf Ahmad Bhat Moonisa Aslam Dervash Kristina Toderich Esra Koc Pedro Garcia Caparros leeb Shahzadi 《Phyton》2023,92(1):165-192
Aluminum is an abundant metal in the earth’s crust that turns out to be toxic in acidic environments. Many plants are affected by the presence of aluminum at the whole plant level, at the organ level, and at the cellular level. Tobacco as a cash crop (Nicotiana tabacum L.) is a widely cultivated plant worldwide and is also a good model organism for research. Although there are many articles on Al-phytotoxicity in the literature, reviews on a single species that are economically and scientifically important are limited. In this article, we not only provide the biology associated with tobacco Al-toxicity, but also some essential information regarding the effects of this metal on other plant species (even animals). This review provides information on aluminum localization and uptake process by different staining techniques, as well as the effects of its toxicity at different compartment levels and the physiological consequences derived from them. In addition, molecular studies in recent years have reported specific responses to Al toxicity, such as overexpression of various protective proteins. Besides, this review discusses data on various organelle-based responses, cell death, and other mechanisms, data on tobacco plants and other kingdoms relevant to these studies. 相似文献
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The cyanide degradation abilities of three white rot fungi, Trametes versicolor ATCC 200801, Phanerochaete chrysosporium ME 496 and Pleurotus sajor-caju, were examined. T. versicolor was the most effective with 0.35 g dry cell/100 ml degrading 2 mm KCN (130 mg/l) over 42 h, at 30°C, pH 10.5 with stirring at 150 rpm. 相似文献
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Yilmaz N Karaali K Ozdem S Turkay M Unal A Dora B 《Cellular and molecular neurobiology》2011,31(4):579-585
Although migraine has mainly been considered as a benign disease, there is cumulative evidence of silent changes in the brain,
brainstem, or cerebellum and subtle subclinical cerebellar dysfunction. In this study, in order to investigate a possible
neuronal and/or glial damage at the cellular level in migraine, we measured and compared serum levels of S100B which is a
protein marker of glial damage or activation, and neuron specific enolase (NSE) which is a marker of neuronal damage, in migraine
patients and control subjects. Serum levels of S100B and NSE were measured in blood samples from 41 patients with migraine-without
aura taken during a migraine attack (ictal) and in the attack-free period between migraine attacks (interictal) and 35 age-
and sex-matched controls. Patients with migraine-without aura had significantly higher ictal serum levels of S100B and NSE
(P < 0.05, for both) than control subjects; whereas in the interictal phase, there was a significant increment only in S100B
levels (P < 0.05) compared to controls. On the other hand, serum levels of S100B and NSE in ictal and interictal blood samples did
not differ significantly. The findings of increased ictal serum S100B and NSE levels together with increased interictal levels
of S100B suggested that migraine might be associated with glial and/or neuronal damage in the brain and a prolonged disruption
of blood–brain barrier. Increased interictal serum levels of S100B might point out to an insidious and slow damaging process
in migraine patients. 相似文献