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Hubbard RD Bamaung NY Palazzo F Zhang Q Kovar P Osterling DJ Hu X Wilsbacher JL Johnson EF Bouska J Wang J Bell RL Davidsen SK Sheppard GS 《Bioorganic & medicinal chemistry letters》2007,17(19):5406-5409
A high throughput screen of Abbott's compound repository revealed that the pyrazolo[3,4-d]pyrimidine class of kinase inhibitors possessed moderate potency for IGF-IR, a promising target for cancer chemotherapy. The synthesis and subsequent optimization of this class of compounds led to the discovery of 14, a compound that possesses in vivo IGF-IR inhibitory activity. 相似文献
63.
SEIDLOVA F.; LOZHNIKOVA V. N.; NEGRETSKY V. A.; CHAILAKHYAN M. KH. 《Journal of experimental botany》1990,41(10):1347-1349
Anatomical changes in the shoot apex of Chenopodium rubrum L.treated with an extract from flowering tobacco plants and cultivatedin non-inductive conditions are described. They are comparedwith the anatomy of non-treated vegetative apices and with apicesof plants induced with a short day. Treatment with the extractresulted in both activation of cell division in the upper partof the apex and in apex elongation. Acceleration of leaf primordiainitiation and stimulation of branching took place. The effectcorresponds to the sequence of changes in photoperiodically-inducedplants but is more pronounced. Elongation following 104M GA3 treatment was of a differentnature; there was only a slight stimulation in the upper partof the apex in contrast with a strong stimulation of growthin length in the lower internodes. These preliminary resultssuggest a similarity between apical changes evoked by a stimulusproduced by short days and an exogenously applied floral stimulus.The changes differed from those caused by exogenous phytohormones. Key words: Chenopodium rubrum, florigen, shoot apex 相似文献
64.
Wagner R Mollison KW Liu L Henry CL Rosenberg TA Bamaung N Tu N Wiedeman PE Or Y Luly JR Lane BC Trevillyan J Chen YW Fey T Hsieh G Marsh K Nuss M Jacobson PB Wilcox D Carlson RP Carter GW Djuric SW 《Bioorganic & medicinal chemistry letters》2005,15(23):5340-5343
The synthesis and biological activities of rapamycin (I) analogs modified at the C-40 position are reported. Emphasis placed on compounds that potentially have an improved safety profile on account of their shorter in vivo half-life when compared with rapamycin. 相似文献
65.
K. Nwe M. Bernardo C.A.S. Regino M. Williams M.W. Brechbiel 《Bioorganic & medicinal chemistry》2010,18(16):5925-5931
In this report we directly compare the in vivo and in vitro MRI properties of gadolinium–dendrimer conjugates of derivatized acyclic diethylenetriamine-N,N′,N′,N″,N″-pentaacetic acid (1B4M-DTPA) and macrocyclic 1,4,7,10-tetraazacyclododecane-N,N′,N″,N?-tetraacetic acid (C-DOTA). The metal–ligand chelates were pre-formed in alcohol prior to conjugation to the generation 4 PAMAM dendrimer (G4D), and the dendrimer-based agents were purified by Sephadex® G-25 column. The analysis and SE-HPLC data indicated chelate to dendrimer ratios of 30:1 and 28:1, respectively. Molar relaxivity measured at pH 7.4, 22 °C, and 3T are comparable (29.5 vs 26.9 mM?1 s?1), and both conjugates are equally viable as MRI contrast agents based on the images obtained. The macrocyclic agent however exhibits a faster rate of clearance in vivo (t1/2 = 16 vs 29 min). Our conclusion is that the macrocyclic-based agent is the more suitable agent for in vivo use for these reasons combined with kinetic inertness associated with the Gd(III) DOTA complex stability properties. 相似文献
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A bioprocess for machine washable wool, combining the advantages of both protease and transglutaminase in a simultaneous enzymatic treatment has been developed. This process reduced the felting tendency of woven wool fabrics by 9% at the expense of only 2% weight and tensile strength loss. In contrast to previously described protease-based processes for shrink resistant wool, the anti-felting properties achieved in the simultaneous enzymatic treatment produced insignificant fibre damage, confirmed also by scanning electron images of the fabrics. 相似文献
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This is the first record of the discovery in Myanmar ofAchlya klebsiana, belonging to the family Saprolegniaceae. 相似文献