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121.
Józef Nusbaum 《Development genes and evolution》1907,24(1):124-130
Ohne Zusammenfassung 相似文献
122.
Pycnidiospores of Phyllosticta ampelicida, the causal agent of black rot of grape, were found to germinate only on substrata on which they were firmly attached. Such surfaces were poorly wettable and had advancing contact angles (straight thetaa) formed by a water drop of >80°, e.g., grape leaf, polystyrene, Teflon, polycarbonate, collodion, and glass treated with the silanes n-octadecyltrichlorosilane, dimethyldichlorosilane, or diphenyldichlorosilane. When pycnidiospores were deposited on more wettable surfaces they did not attach firmly and did not germinate. Such highly wettable surfaces had straight thetaa = 40° and were represented by heat-treated glass, cellophane, nutrient- and water-agars, polystyrene treated with UV-irradiation or sulfuric acid, and glass silanized with n-2-aminoethyl-3-aminopropyltrimethoxysilane, n-(trimethoxysilylpropyl)ethylenediamine triacetic acid trisodium, or 3-aminopropyltriethoxysilane. Adhesion of pycnidiospores was assessed with and without a hydraulic shearing force. Pycnidiospore adhesion occurred over several minutes in distilled deionized water, unless it was first acidified, which decreased attachment time to <0.03 s. Attachment of pycnidiospores treated with sodium azide, formaldehyde, or boiled in water for 10 min was similar to nontreated conidia. Possible mechanisms of adhesion of the conidia to surfaces include hydrophobic and ionic interactions. 相似文献
123.
Chandrabose Karthikeyan Pramod Jharia Digambar Kumar Waiker Amy Catherine Nusbaum Haneen Amawi Erin Marie Kirwen Ryann Christman Sri Krishna Chaitanya Arudra Laurent Meijer Amit K. Tiwari Piyush Trivedi 《Bioorganic & medicinal chemistry letters》2017,27(12):2663-2667
Described herein is the design, synthesis and biological evaluation of a series of N-(1H-pyrazol-3-yl)quinazolin-4-amines against a panel of eight disease relevant protein kinases. The kinase inhibition results indicated that two compounds inhibited casein kinase 1δ/ε (CK1δ/ε) with some selectivity over related kinases, namely CDK5/p25, GSK-3α/β, and DYRK1A. Docking studies with 3c and 3d revealed the key interactions with desired amino acids in the ATP binding site of CK1δ. Furthermore, compound 3c also elicited selective cytotoxic activity against the pancreas ductal adenocarcinoma (PANC-1) cell line. Taken together, the results of this study establish N-(1H-pyrazol-3-yl)quinazolin-4-amines especially 3c and 3d as valuable lead molecules with great potential for CK1δ/ε inhibitor development targeting neurodegenerative disorders and cancer. 相似文献
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S J Shin D H Lein A L Aronson S R Nusbaum 《Journal of reproduction and fertility. Supplement》1979,(27):307-315
A total of 19 pathogenic bacterial species was isolated from uterine swabs of 498 out of 1539 mares over 4 years. The swabs were taken by 5 veterinary clinicians using 2 different techniques. Bacterial contamination during swabbing was minimized by scrupulous attention to cleansing of the external genitalia and the perineal area, and in the handling of the culture specimen. The most prevalent organisms isolated were beta-haemolytic streptococcus (39%), Escherichia coli (27%) and Klebsiella pneumoniae (7%). Interpretation of microbiological findings correlated well with clinical findings when number of organisms isolated and endometrial cytology were considered. The use of a bacterial transport medium combined with sophisticated culture methods reflects a more accurate picture of the uterine microflora than can be obtained by previous techniques. Streptococci isolated were uniformly sensitive to penicillins. The sensitivity of E. coli and K. pneumoniae towards chloramphenicol, gentamicin and polymyxin was nearly 100%. The selection of an appropriate antibacterial agent depends upon sensitivity, pharmacological action, genital tract status and cost. This study shows that a Gram stain of uterine cytology can be used to diagnose quickly and select an appropriate antibiotic for treatment prior to culture results if sufficient numbers of organisms are present. 相似文献