Dose-response curves of gamma-irradiated purine and pyrimidine powders.

E.s.r. spectra have been obtained of gamma-irradiated dry purine and pyrimidine powders. Relative radical yields have been calculated and dose-response curves obtained. Relative recombination rates and recombination rates and formation rates of the radicals have been derived from the dose-response curves. The effect of crystalline structure on the dose-response curves is discussed.     

Painful muscle fibrosis following synthol injections in a bodybuilder: a case report

ABSTRACT: INTRODUCTION: Synthol is a site enhancement oil used by bodybuilders to boost the cosmetic appearance ofmuscles. Here, we describe the case of a patient with severe side effects following repeatedintramuscular injections of synthol in his right biceps muscle. CASE PRESENTATION: A 29-year-old Middle Eastern male bodybuilder, following intramuscular injections ofsynthol five years ago, presented with painful pressure in his right upper arm. On presentationto our clinic, his muscle appeared disfigured. Magnetic resonance imaging revealed scatteredcystic fatty lesions in the muscle. The affected part was surgically removed andhistopathology showed inflammatory changes with fibrosis and a so-called Swiss cheesepattern. CONCLUSION: Synthol injections that are used for the short-term enhancement of muscle appearance bybodybuilders bear the danger of long-term painful muscle fibrosis and disfigurement.     

Inhibition of Na+-Ca2+ exchange mechanism in cardiac sarcolemmal vesicles by harmaline

1. Harmaline was found to inhibit the Na+-Ca2+ exchange mechanism present in cardiac sarcolemmal vesicles. 2. The inhibition was dose-dependent and was observed in the range 10(-5) M-10(-2) M harmaline. 3. The effect was demonstrated on both 45Ca2+-uptake and 45Ca2+-efflux. 4. The observed Ki value for harmaline inhibition of 45Ca2+-uptake was found to be 2.5 X 10(-4) M.     

Attentiveness of pediatricians to primary immunodeficiency disorders

ABSTRACT: BACKGROUND: Primary immunodeficiency (PID) is a cluster of serious disorders that requires special alertness on the part of the medical staff for prompt diagnosis and management of the patient. This study explored PID knowledge and experience among pediatricians of wide educational backgrounds, practicing in the United Arab Emirates (UAE). METHOD: A self-administered questionnaire was used to determine the competency of pediatricians in their knowledge of PID disorders. This study questionnaire included questions on PID signs and symptoms, syndromes associated with immunodeficiency, screening tests, interpreting laboratory tests and case management. The participants were 263 pediatricians of diverse education working in the 27 governmental hospitals in all regions of UAE. RESULTS: The overall performance of the pediatricians did not differ based on their age, gender, origin of certification, rank, or years of experience. Of the 50 questions, 20% of pediatricians answered correctly <60% of the questions, 76% answered correctly 60 to 79% of the questions, and 4% answered correctly >80% of the questions. Seventeen of the 19 PID signs and symptoms were identified by 55 to 97%. Four of 5 syndromes associated with immunodeficiency were identified by 50 to 90%. Appropriate screening tests were chosen by 64 to 96%. Attention to the laboratory reference range values as function of patient age was notably limited. CONCLUSIONS: There was a noteworthy deficiency in PID work-up. Therefore, implementing effective educational strategies is needed to improve the competency of pediatricians to diagnose and mange PID disorders.