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71.
Canan Küçükgergin A. Fatih Aydın Gül Özdemirler-Erata Güldal Mehmetçik Necla Koçak-Toker Müjdat Uysal 《Biological trace element research》2010,135(1-3):264-274
Hypercholesterolemia and lipid peroxidation play complementary roles in atherosclerosis. Artichoke (Cynara scolymus L., Asteraceae) leaf extract (ALE), rich in antioxidants, has cholesterol-reducing effect. We investigated the effect of ALE on serum and hepatic lipid levels and pro-oxidant–antioxidant balance in the liver and heart of hypercholesterolemic rats. Rats were fed on 4% (w/w) cholesterol and 1% cholic acid (w/w) supplemented diet for 1 month. ALE (1.5 g/kg/day) was given by gavage during the last 2 weeks. High cholesterol (HC) diet caused significant increases in serum and liver cholesterol and triglyceride levels. It increased malondialdehyde (MDA) and diene conjugate (DC) levels in both tissues. Hepatic vitamin E levels and hepatic and cardiac glutathione peroxidase (GSH-Px) activities decreased, but superoxide dismutase and glutathione transferase activities, glutathione, and vitamin C levels remained unchanged due to HC diet. Serum cholesterol and triglyceride levels and ratio of cholesterol to high-density lipoprotein (HDL)-cholesterol decreased in ALE plus HC-treated rats, but liver cholesterol and triglyceride levels remained unchanged. Significant decreases in hepatic and cardiac MDA and DC levels and increases in hepatic vitamin E and GSH-Px activities were observed in ALE-treated hypercholesterolemic rats. Our results indicate that ALE decreases serum lipids and hypercholesterolemia-induced pro-oxidant state in both tissues. 相似文献
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Kürtüncü M Tüzün E Türkoğlu R Petek-Balcı B Içöz S Pehlivan M Birişik Ö Ulusoy C Shugaiv E Akman-Demir G Eraksoy M 《Cytokine》2012,59(2):400-402
Therapeutic effect of interferon-β (IFN-β) treatment has been associated with modulation of the balance between Th1, Th17, Th2 and regulatory T (Treg) cells, whereas the impact of disease modifying drugs on Th9-immunity in multiple sclerosis (MS) has not been studied. To investigate the short-term effects of IFN-β treatment on cytokines in MS, we determined serum levels of IL-17, IL-23, IL-10, IL-4, IFN-γ, IL-9 and TGF-β in relapsing remitting MS patients before and 2 months after IFN-β treatment by ELISA. MS patients showed increased IL-17, IL-23 and IL-4 levels and decreased IL-9 levels as compared to healthy controls. IFN-β treatment only reduced IL-17 and IL-23 levels, whereas the levels of other cytokines remained unchanged. IFN-β treatment appears to exert its earliest therapeutic effect on Th17-immunity. The influence of IL-9 on MS pathogenesis needs to be further studied. 相似文献
74.
Diagnosis and phylogenetic analysis of orf virus in Aleppo and Saanen goats from an outbreak in Turkey 总被引:1,自引:0,他引:1
正Dear Editor,The Poxviridae family is divided into Chordopoxvirinae and Entomopoxvirinae genera.Parapoxvirus is one of 11genera in the Chordopoxvirinae genus,including orf virus(ORFV),bovine papular stomatitis virus(BPSV),pseudocowpox virus(PCPV)and parapoxvirus of red deer in New Zealand(PVNZ)(Skinner et al.,2012).This virus,also known as contagious ecthyma or contagious pustular dermatitis,is a viral skin disease causing edematous proliferative lesions,most often in hairless skin 相似文献
75.
Karacocuk Tugba Sevik Hakan Isinkaralar Kaan Turkyilmaz Aydın Cetin Mehmet 《Landscape and Ecological Engineering》2022,18(1):75-83
Landscape and Ecological Engineering - In recent years, air pollution has increased significantly due to anthropogenic factors and has become a global problem. Heavy metals in air pollution... 相似文献
76.
Kirtis Arife Aasim Muhammad Katırcı Ramazan 《Plant Cell, Tissue and Organ Culture》2022,150(1):141-152
Plant Cell, Tissue and Organ Culture (PCTOC) - In vitro whole plant regeneration protocol of desi chickpea was established followed by generating the model prediction using different machine... 相似文献
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Sleep and Biological Rhythms - Restless leg syndrome (RLS) is a sensory-motor problem characterized by an uncomfortable and unpleasant feeling that causes a strong and irresistible desire to move... 相似文献
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Ozlem Bakir Boga Ahmet Bugra Ortaakarsu Beyzanur Kadırustaoglu Esabi Basaran Kurbanoglu 《化学与生物多样性》2023,20(3):e202201142
In this study, total phenolic and flavonoid analyses of flower, leaf, and stem aqueous extracts of C. orientalis were performed. Total phenolic contents of C. orientalis extracts ranged from 12.2±0.06 to 19.0±0.07 mg GAE/g extract. Total flavonoid values range between 2.0±0.11 and 6.6±0.19 mg CE/g extract. Urease, collagenase, tyrosinase, and α-glucosidase inhibition activities were determined in vitro and the relationship between them was examined. IC50 results for all enzymes were obtained between 0.18 and 3.53 μg/mL. The aqueous extract of the plant C. orientalis showed potent cytotoxic effects against the human colon cancer cell lines DLD-1. As the extract concentration increases, cell death increases. The main fatty acid composition by GC/MS analysis is erucic acid (36.5 %). The potential binding modes of the fatty acids in the plant extract to the enzymes and possible inhibition mechanisms were determined by molecular docking calculation. 相似文献