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Kazakova TB Novikova NS Korneva EA 《Rossi?skii fiziologicheski? zhurnal imeni I.M. Sechenova / Rossi?skaia akademiia nauk》2006,92(6):677-691
The results of investigations of the new discovered brain orexin neurons, their chemical structure, localization and functions are reviewed. The following data are described: the specifics of orexins mRNA, orexins A and B and their receptors; connections between orexin neurons and neurons from different structures of the brain and spinal cord and the participation of the orexin neuron system in the functional regulation. 相似文献
64.
Gavrilov IuV Perekrest SV Novikova NS 《Rossi?skii fiziologicheski? zhurnal imeni I.M. Sechenova / Rossi?skaia akademiia nauk》2006,92(10):1195-1203
Hypothalamic structures become activated after stimul. Alteration of c-Fos-positive cells quantity in different hypothalamic structures after electric pain stimulation (EPS), intravenous (iv) injection of antigens (lioppolysaccharide (LPS) and bovine serum albumir (BSA)) was detected with immunohistochemical method. EPS and iv injection of antigens (LPS and BSA) result in c-Fos-positive cells quantity increase in all observed hypothalamic structures. The highest activation level was in AHN and PH after EPS and in AHN, PVH, LHA-28, and PH after iv LPS injection. Comparative analysis of results showed, that c-Fos-positive cells quantity increase after EPS in AHN, PVH, LHA and PH was more significant than after iv injection of antigens (LPS and BSA). LPS injection results in more pronounced cell activation in AHN, PVH, LHA-28 and DMH (according to quantity of c-Fos-positive cells), than BSA injection. 相似文献
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Molecular phylogeny of Palaearctic genera of Gomphocerinae grasshoppers (Orthoptera, Acrididae) 总被引:2,自引:0,他引:2
Alexander Bugrov Olga Novikova Vladimir Mayorov Linda Adkison Alexander Blinov 《Systematic Entomology》2006,31(2):362-368
Abstract. Molecular phylogenetic methods were used to examine morphologically based hypotheses concerning the taxonomic structure and relationships of the grasshopper subfamily Gomphocerinae. Two mitochondrial gene (cytochrome b and cytochrome oxidase subunit I) sequences were determined for twenty-five species representing eleven Palaearctic genera. The studied Gomphocerinae species constituted a monophyletic group; furthermore, the earlier division of Gomphocerinae into tribes was supported, with each tribe monophyletic. There was no support for various systems uniting Stenobothrini and Gomphocerini into one tribe. Two separate clusters were discerned in Gomphocerini and two tribes were distinguished – Gomphocerini (genera Aeropus , Stauroderus , Chorthippus ) and Stenobothrini (genera Omocestus , Stenobothrus ). 相似文献
67.
Lazareva NA Saltykov KA Shevelev IA Tikhomirov AS Novikova RV Tsutskiridze DIu 《Zhurnal vysshe? nervno? deiatelnosti imeni I P Pavlova》2006,56(4):506-515
In 27 acute experiments with anesthetized and immobilized adult cats 101 maps of receptive field (RF) in 67 striate neurons were studied by means of mapping with single flashed stimuli presented in different parts of the visual field and under conditions of additional activation of the RF excitatory center by the local oscillating or flashing grid. Under conditions of both classical and combined modes of mapping, the RFs of the classical shape with a single excitatory zone (63.4 and 29.3% of cases, respectively) and RFs with multiple (2-5) excitatory and/or inhibitory zones (36.6 and 70.7%, respectively) were found. We were the first to describe, also, some RFs of horseshoe-like, cross-like and T-like shapes. Simulation of non-classical RFs revealed possible contributions of cooperative excitatory and inhibitory intracortical interactions to the effects under study. The functional role of RFs of different types in the feature detection is discussed. 相似文献
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R Loganathan L Novikova IG Boulatnikov IV Smirnova 《Journal of applied physiology (Bethesda, Md. : 1985)》2012,113(5):817-826
One of the fundamental biochemical defects underlying the complications of diabetic cardiovascular system is elevation of diacylglycerol (DAG) and its effects on protein kinase C (PKC) signaling. It has been noted that exercise training attenuates poor cardiac performance in Type 1 diabetes. However, the role of PKC signaling in exercise-induced alleviation of cardiac abnormalities in diabetes is not clear. We investigated the possibility that exercise training modulates PKC-βII signaling to elicit its beneficial effects on the diabetic heart. bio-breeding diabetic resistant rats, a model reminiscent of Type 1 diabetes in humans, were randomly assigned to four groups: 1) nonexercised nondiabetic (NN); 2) nonexercised diabetic (ND); 3) exercised nondiabetic; and 4) exercised diabetic. Treadmill training was initiated upon the onset of diabetes. At the end of 8 wk, left ventricular (LV) hemodynamic assessment revealed compromised function in ND compared with the NN group. LV myocardial histology revealed increased collagen deposition in ND compared with the NN group, while electron microscopy showed a reduction in the viable mitochondrial fraction. Although the PKC-βII levels and activity were unchanged in the diabetic heart, the DAG levels were increased. With exercise training, the deterioration of LV structure and function in diabetes was attenuated. Notably, improved cardiac performance in training was associated with a decrease in myocardial DAG levels in diabetes. Exercise-induced benefits on cardiac performance in diabetes may be mediated by prevention of an increase in myocardial DAG levels. 相似文献
70.
Zakataeva NP Romanenkov DV Skripnikova VS Vitushkina MV Livshits VA Kivero AD Novikova AE 《Applied microbiology and biotechnology》2012,93(5):2023-2033
Bacillus strains are used for the industrial production of the purine nucleosides inosine and guanosine, which are raw materials for
the synthesis of the flavor enhancers disodium inosinate and disodium guanylate. An important precursor of purine nucleosides
is 5-phospho-α-d-ribosyl-1-pyrophosphate, which is synthesized by phosphoribosyl pyrophosphate synthetase (PRS, EC 2.7.6.1). Class I PRSs
are widespread in bacteria and mammals, are highly conserved among different organisms, and are negatively regulated by two
end products of purine biosynthesis, adenosine 5′-diphosphate (ADP) and guanosine 5′-diphosphate (GDP). The D52H, N114S, and
L129I mutations in the human PRS isozyme I (PRS1) have been reported to cause uric acid overproduction and gout due to allosteric
deregulation and enzyme superactivity. In this study, to find feedback-resistant Bacillus amyloliquefaciens PRS, the influence of the D58H, N120S, and L135I mutations (corresponding to the D52H, N114S, and L129I mutations in PRS1,
respectively) on PRS enzymatic properties has been studied. Recombinant histidine-tagged wild-type PRS and three mutant PRSs
were expressed in Escherichia coli, purified, and characterized. The N120S and L135I mutations were found to release the enzyme from ADP and GDP inhibition
and significantly increase its sensitivity to inorganic phosphate (Pi) activation. In contrast, PRS with the D58H mutation exhibited nearly identical sensitivity to ADP and GDP as the wild-type
protein and had a notably greater Pi requirement for activation. The N120S and L135I mutations improved B. amyloliquefaciens and Bacillus subtilis purine nucleoside-producing strains. 相似文献