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排序方式: 共有79条查询结果,搜索用时 171 毫秒
61.
Gjelstad IM Haugen F Gulseth HL Norheim F Jans A Bakke SS Raastad T Tjønna AE Wisløff U Blaak EE Risérus U Gaster M Roche HM Birkeland KI Drevon CA 《Archives of physiology and biochemistry》2012,118(1):22-30
The perilipin proteins enclose intracellular lipid droplets. We describe the mRNA expression of the five perilipins in human skeletal muscle in relation to fatty acid supply, exercise and energy balance. We observed that all perilipins were expressed in skeletal muscle biopsies with the highest mRNA levels of perilipin 2, 4 and 5. Cultured myotubes predominantly expressed perilipin 2 and 3. In vitro, incubation of myotubes with fatty acids enhanced mRNA expression of perilipin 1, 2 and 4. In vivo, low fat diet increased mRNA levels of perilipin 3 and 4. Endurance training, but not strength training, enhanced the expression of perilipin 2 and 3. Perilipin 1 mRNA correlated positively with body fat mass, whereas none of the perilipins were associated with insulin sensitivity. In conclusion, all perilipins mRNAs were expressed in human skeletal muscle. Diet as well as endurance exercise modulated the expression of perilipins. 相似文献
62.
SHOUMITRO DEB HENRY KWOK MARCO BERTELLI LUIS SALVADOR‐CARULLA ELSPETH BRADLEY JENNIFER TORR JARRET BARNHILL FOR THE GUIDELINE DEVELOPMENT GROUP OF THE WPA SECTION ON PSYCHIATRY OF INTELLECTUAL DISABILITY 《World psychiatry》2009,8(3):181-186
Psychotropic medications are used regularly to manage problem behaviours among people with intellectual disabilities. This causes concern because often these medications are used out of their licensed indications in this context. The WPA Section on Psychiatry of Intellectual Disability has recently developed an evidence and consensus-based international guide for practitioners for the use of psychotropic medications for problem behaviours among adults with intellectual disabilities. This guide advises on assessment of behaviours, producing a formulation, initiation of treatment, assessment of out-come and adverse effects, follow-up arrangements, and possibility of discontinuation of treatment. 相似文献
63.
No?lle Mistretta Delphine Seguin Jer?me Thiébaud Sandrine Vialle Frédéric Blanc Marina Brossaud Philippe Talaga Gunnstein Norheim Monique Moreau Bachra Rokbi 《The Journal of biological chemistry》2010,285(26):19874-19883
The lipooligosaccharide (LOS) of immunotype L11 is unique within serogroup A meningococci. In order to resolve its molecular structure, we conducted LOS genotyping by PCR analysis of genes responsible for α-chain sugar addition (lgtA, -B, -C, -E, -H, and -F) and inner core substituents (lgtG, lpt-3, and lpt-6). For this study, we selected seven strains belonging to subgroup III, a major clonal complex responsible for meningococcal meningitis epidemics in Africa. In addition, we sequenced the homopolymeric tract regions of three phase-variable genes (lgtA, lgtG, and lot-3) to predict gene functionality. The fine structure of the L11 LOS of each strain was determined using composition and glycosyl linkage analyses, NMR, and mass spectrometry. The masses of the dephosphorylated oligosaccharides were consistent with an oligosaccharide composed of two hexoses, one N-acetyl-hexosamine, two heptoses, and one KDO, as proposed previously. The molar composition of LOS showed two glucose residues to be present, in agreement with lgtH sequence prediction. Despite phosphoethanolaminetransferase genes lpt-3 and lpt-6 being present in all seven Neisseria meningitidis strains, phosphoethanolamine (PEtn) was found at both O-3 and O-6 of HepII among the three ST-5 strains, whereas among the four ST-7 strains, only one PEtn was found and located at O-3 of the HepII. The L11 LOS was found to be O-acetylated, as was indicated by the presence of the lot-3 gene being in-frame in all of the seven N. meningitidis strains. To our knowledge, these studies represent the first full genetic and structural characterization of the L11 LOS of N. meningitidis. These investigations also suggest the presence of further regulatory mechanisms affecting LOS structure microheterogeneity in N. meningitidis related to PEtn decoration of the inner core. 相似文献
64.
BY THE EARL OF CRANBROOK H. G. BARRETT APPENDIX ON NET SHYNESS BY F. YATES 《Journal of Zoology》1965,144(1):1-24
In the summer and early autumn of 1960, 1961 and 1962, noctule bats flying low, taking house crickets as these flew from a municipal rubbish tip, were captured in mist nets, ringed, released and in many cases recaptured a number of times. The flying bats showed no fear of human beings or predatory birds and did not learn to avoid the net. In June and July of each year the majority of bats caught were adult females, the flying young of the year first appearing in August though some did not fly until September and October. Young males did not reach sexual maturity in the year of their birth, though five out of fourteen females recaptured at a year old did. There was a considerable movement of adult males in the late summer, adult bats being captured in approximately equal numbers of both sexes during August and September. In October the females seemed to disappear, the majority of the bats caught during that month being males: by November the crickets had ceased to fly and no more bats could be captured though a few wero still flying on warm nights. There was a marked difference in feeding behaviour over these three years, the bats concentrating more on crickets in 1960 than in 1961 and 1962. Though the differences are not statistically significant there were indications of an increase in body weight between July and October in the years when less cricket feeding was occurring. About 50 per cent of the females captured in each of the years 1960 and 1961 were recaptured feeding on the same site in the following year: the recovery rate of males was about 30 per cent in 1961, 60 per cent in 1962. 相似文献
65.
The concentrations of copper, zinc and molybdenum were measured in samples of cattle liver from 10 slaughter-houses in Norway. A total of 335 samples were analysed. A clear accumulation of copper with age was found, the average copper level in the younger animals (≦ 3 years, n = 194) being 30 µg Cu/g liver wet weight, and in the older ones (> 3 years, n = 141) 59 µg Gu/g. The range in the copper values found was considerable, though significant differences between some of the districts were recorded. Copper concentrations were classified as low (≦10 µg Gu/g) in 9.6 % of the samples. Zinc showed no accumulation with age, nor were there any differences in zinc levels found in animals from different districts, the average level being 32 µg Zn/g liver wet weight. The picture was the same for molybdenum, no differences between age groups or districts being found. The average level was 1.0 µg Mo/g liver. There was no significant correlation between levels of copper, zinc or molybdenum. The supply of copper and zinc to cattle in Norway seems close to sufficient, but copper- and zinc-fortified mineral supplementation of cattle feed is still to be recommended. There seems to be no need for molybdenum supplementation in cattle. 相似文献
66.
67.
MILTON L. WAINBERG KAREN MCKINNON KATHERINE ELKINGTON PAULO E. MATTOS CLAUDIO GRUBER MANN DIANA DE SOUZA PINTO LAURA OTTO-SALAJ FRANCINE COURNOS AND THE INVESTIGATORS OF PRISSMA 《World psychiatry》2008,7(3):166-172
We conducted the first study to examine rates of sexual activity, sexual risk behaviors, sexual protective behaviors, injection drug use (IDU), needle sharing, and knowledge about HIV/AIDS among outpatients with severe mental illness (SMI) in Rio de Janeiro, Brazil. Using a measure with demonstrated reliability, we found that 42% of 98 patients engaged in vaginal or anal sex within the past three months. Comorbid substance use disorder was significantly associated with sexual activity. Only 22% of sexually active patients used condoms consistently, despite having better HIV knowledge than those who were sexually abstinent. Overall, 45% of patients reported not engaging in any HIV protective behaviors. There were no reports of drug injection. Adults with SMI in Brazil are in need of efficacious HIV prevention programs and policies that can sustain these programs within mental health treatment settings. 相似文献
69.
马尾松毛虫成虫性引诱的初步观察 总被引:5,自引:0,他引:5
马尾松毛虫(Dendrolimus punctatus Walker)在我国分布广,每年发生代数多,严重威胁松林的生长(蔡邦华,1960)。虽然飞机药剂防治能够缩短防治时间,节省人力,提高杀虫率,但还存在一些问题,为了进一步寻找新的、高效、经济、安全的防治手段,鉴于利用性引诱剂防治害虫,一方面既有可能提高杀虫药剂的使用效率,降低药剂的使用量,缩小污染范围,解决残毒的问题,而另一方面,借助性引诱剂对害虫繁殖潜力的破坏作用(Beroza,1971; Shorey & Gaston,1967;Stevens & 相似文献
70.
Comparing global models of terrestrial net primary productivity (NPP): global pattern and differentiation by major biomes 总被引:1,自引:0,他引:1