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41.
42.
Neves RH Miranda de Barros Alencar AC Costa-Silva M Aguila MB Mandarim-de-Lacerda CA Machado-Silva JR Gomes DC 《Experimental parasitology》2007,115(4):324-332
This study investigated whether long-term feeding a high-fat diet (HFC) has an effect on schistosomiasis mansoni outcome compared to standard chow diet (SC). Swiss Webster female mice (3 wk old) fed each diet over 5 months, and then were infected with 50 Schistosoma mansoni cercariae. Their nutritional status was assessed by monitoring growth rates twice a week and measuring serum levels of lipoproteins. Mice were euthanised 63 days after infection. Parasitological and liver histological analyses were performed. The levels of TC, HDL-C and LDL-C, fecal and tissue schistosome eggs were statistically different (p<0.05) between groups. Livers from HFC mice showed exudative, exudative/exudative-productive, exudative-productive and productive granulomas, some degree of hepatic steatosis and focal necrosis. Mice fed normal-chow did not present productive granulomas and hepatic steatosis. The morphometric evaluation of hepatic granulomas did not reach statistical significance (p>0.05) between diets assayed. The high-fat diet for long-term produces effects on schistosomiasis mansoni outcome. 相似文献
43.
Barbara Repetto Alberto Palenzona Simone Cagnacci Eugenio A. Debbia Anna Marchese 《Annals of microbiology》2007,57(3):439-442
Pseudomonas aeruginosa is an opportunistic pathogen, intrinsically resistant to many antibiotics and prone to acquire resistance against many drugs. It is assumed that agents that disorganise the structure of the outer membrane might allow the passage of other drugs into cell. To verify this hypothesis, ceftazidime (CAZ) has been tested in association with glycopeptides (GLYs) and azithromycin (AZI). Time-kill experiments were performed on a representative strain. CAZ in combination with GLYs showed 99, 90 and 10% of CFU/ml reduction in 33.9,52.5 and 13.6% of the cases, respectively; the addition of AZI increased the incidence of 99% CFU/ml reduction to 42% of the cases. Indifference was the most common finding, and additive/synergism in the other cases. Present findings demonstrated that CAZ favourably reacted with GLYs in the presence of AZI. 相似文献
44.
Soncini M Vesentini S Ruffoni D Orsi M Deriu MA Redaelli A 《Biomechanics and modeling in mechanobiology》2007,6(6):399-407
Alpha-actinin is a cytoskeleton-binding protein involved in the assembly and regulation of the actin filaments. In this work
molecular dynamics method was applied to investigate the mechanical behaviour of the human skeletal muscle α-actinin. Five
configurations were unfolded at an elongation speed of 0.1 nm/ps in order to investigate the conformational changes occurring
during the extension process. Moreover, a sensitivity analysis at different velocities was performed for one of the R2–R3
spectrin-like repeat configuration extracted in order to evaluate the effect of the pulling speed on the mechanical behaviour
of the molecule. Two different behaviours were recognized with respect to the pulling speed. In particular, at speed higher
than 0.025 nm/ps a continuous rearrangement without evident force peaks was obtained, on the contrary at lower speed evident
peaks in the range 500–750 pN were detected. R3 repeat resulted more stable than R2 during mechanical unfolding, due to the
lower hydrophobic surface available to the solvent. The characterization of the R2–R3 units can be useful for the development
of cytoskeleton network models based on stiffness values obtained by analyses performed at the molecular level. 相似文献
45.
46.
Ippolito Alberto DeSimone Antonio Deshpande Vikram S. 《Biomechanics and modeling in mechanobiology》2022,21(4):1043-1065
Biomechanics and Modeling in Mechanobiology - Adherent cells seeded on substrates spread and evolve their morphology while simultaneously displaying motility. Phenomena such as contact guidance,... 相似文献
47.
Chromosoma - Centrosomes represent the major microtubule organizing center (MTOC) in eukaryotic cells and are responsible for nucleation of the spindle, the vehicle of chromosome segregation. In... 相似文献
48.
Buonomo Bruno Manfredi Piero d’Onofrio Alberto 《Journal of mathematical biology》2019,78(4):1089-1113
Journal of Mathematical Biology - In order to seek the optimal time-profiles of public health systems (PHS) Intervention to favor vaccine propensity, we apply optimal control (OC) to a SIR model... 相似文献
49.
Nuclear lipids: New functions for old molecules? 总被引:7,自引:0,他引:7
Martelli AM Tabellini G Borgatti P Bortul R Capitani S Neri LM 《Journal of cellular biochemistry》2003,88(3):455-461
It is becoming increasingly evident that stimulation of nuclear lipid metabolism plays a central role in many signal transduction pathways that ultimately result in various cell responses including proliferation and differentiation. Nuclear lipid metabolism seems to be at least as complex as that existing at the plasma membrane. However, a distinctive feature of nuclear lipid biochemical pathways is their operational independence from their cell periphery counterparts. Although initially it was thought that nuclear lipids would serve as a source for second messengers, recent evidence points to the likelihood that lipids present in the nucleus also fulfil other roles. The aim of this review is to highlight the most intriguing advances made in the field over the last year, such as the production of new probes for the in situ mapping of nuclear phosphoinositides, the identification of two sources for nuclear diacylglycerol production, the emerging details about the peculiar regulation of nuclear phosphoinositide synthesizing enzymes, and the distinct possibility that nuclear lipids are involved in processes such as chromatin organization and pre-mRNA splicing. 相似文献
50.
Luciana Gabriel Nogueira Ronaldo Honorato Barros Santos Barbara Maria Ianni Alfredo Inácio Fiorelli Eliane Conti Mairena Luiz Alberto Benvenuti Amanda Frade Eduardo Donadi Fabrício Dias Bruno Saba Hui-Tzu Lin Wang Abilio Fragata Marcelo Sampaio Mario Hiroyuki Hirata Paula Buck Charles Mady Edimar Alcides Bocchi Noedir Antonio Stolf Jorge Kalil Edecio Cunha-Neto 《PLoS neglected tropical diseases》2012,6(10)