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201.
Nguyen Xuan Cuong Nguyen Xuan Nhiem Nguyen Phuong Thao Nguyen Hoai Nam Nguyen Tien Dat Hoang Le Tuan Anh Le Mai Huong Phan Van Kiem Chau Van Minh Ji-Hee Won Won-Yoon Chung Young Ho Kim 《Bioorganic & medicinal chemistry letters》2010,20(16):4782-4784
Ten phenolic compounds (1–10) were isolated from a methanol extract of Lawsonia inermis leaves including two new ones, lawsoniasides A (1) and B (2). Their structures were elucidated by spectroscopic methods (NMR and FTICRMS) in combination with acid hydrolysis and GC analyses. Compounds 4 and 5 showed a significant inhibition on receptor activator for nuclear factor-κB ligand-induced osteoclast formation in murine bone-marrow macrophages. 相似文献
202.
Aleem Gangjee Hiteshkumar D. Jain Jaclyn Phan Xin Guo Sherry F. Queener Roy L. Kisliuk 《Bioorganic & medicinal chemistry》2010,18(2):953-961
A novel classical antifolate N-{4-[(2,4-diamino-5-methyl-furo[2,3-d]pyrimidin-6-yl)thio]-benzoyl}-l-glutamic acid 5 and 11 nonclassical antifolates 6–16 were designed, synthesized, and evaluated as inhibitors of dihydrofolate reductase (DHFR) and thymidylate synthase (TS). The nonclassical compounds 6–16 were synthesized from 20 via oxidative addition of substituted thiophenols using iodine. Peptide coupling of the intermediate acid 21 followed by saponification gave the classical analog 5. Compound 5 is the first example, to our knowledge, of a 2,4-diamino furo[2,3-d]pyrimidine classical antifolate that has inhibitory activity against both human DHFR and human TS. The classical analog 5 was a nanomolar inhibitor and remarkably selective inhibitor of Pneumocystis carinii DHFR and Mycobacterium avium DHFR at 263-fold and 2107-fold, respectively, compared to mammalian DHFR. The nonclassical analogs 6–16 were moderately potent against pathogen DHFR or TS. This study shows that the furo[2,3-d]pyrimidine scaffold is conducive to dual human DHFR-TS inhibitory activity and to high potency and selectivity for pathogen DHFR. 相似文献
203.
Trinh Thi Thuy Nguyen Thi Thu Hoa Nguyen Thi Thuy Linh Ba Thi Cham Nguyen Thi Hoang Anh Nguyen Tuan Hiep Sabrina Adorisio Domenico V Delfino Ngo Anh Bang Bui Huu Tai Phan Van Kiem 《化学与生物多样性》2023,20(10):e202301166
Gnetum latifolium var. funiculare Markgr. is a medicinal plant and widely distributed in mountainous areas of Vietnam. Phytochemical investigation on the trunks of this plant afforded eight stilbene derivatives ( 1 – 8 ) including for new compounds ( 1 – 4 ). Their structures were determined based on extensive analyses of HR-ESI-MS, 1D and 2D NMR spectra. Among the isolates, compounds 1 – 3 showed moderate NO production inhibition in LPS-activated RAW264.7 cells with the IC50 values ranging from 46.81 to 68.10 μM, compounds 4 and 6 showed weak effects with the IC50 values of 96.57 and 79.46 μM, respectively, compared to that of the positive control compound, dexamethasone (IC50 14.20 μM). 相似文献
204.
Kumari Pragati Singh Sumer Yadav Saurabh Tran Lam-Son Phan 《Journal of plant research》2021,134(5):1149-1154
Journal of Plant Research - A comparative regeneration of three types of explants prepared from axillary meristems, plumular apices and hypocotyls of chickpea (Cicer arietinum) was carried out... 相似文献
205.
Rao Sathyanarayan Lesparre Nolwenn Flores-Orozco Adrián Wagner Florian Kemna Andreas Javaux Mathieu 《Plant and Soil》2021,460(1-2):453-468
Plant and Soil - Soil microorganisms play an important role in biogeochemical cycles in terrestrial ecosystems. Increasing nitrogen (N) and phosphorus (P) deposition are likely to regulate... 相似文献
206.
Ernest Chi Fru Nolwenn Callac Nicole R. Posth Ariadne Argyraki Yu-Chen Ling Magnus Ivarsson Curt Broman Stephanos P. Kilias 《Biogeochemistry》2018,141(1):41-62
The toxicity of arsenic (As) towards life on Earth is apparent in the dense distribution of genes associated with As detoxification across the tree of life. The ability to defend against As is particularly vital for survival in As-rich shallow submarine hydrothermal ecosystems along the Hellenic Volcanic Arc (HVA), where life is exposed to hydrothermal fluids containing up to 3000 times more As than present in seawater. We propose that the removal of dissolved As and phosphorus (P) by sulfide and Fe(III)(oxyhydr)oxide minerals during sediment–seawater interaction, produces nutrient-deficient porewaters containing?<?2.0 ppb P. The porewater arsenite-As(III) to arsenate-As(V) ratios, combined with sulfide concentration in the sediment and/or porewater, suggest a hydrothermally-induced seafloor redox gradient. This gradient overlaps with changing high affinity phosphate uptake gene abundance. High affinity phosphate uptake and As cycling genes are depleted in the sulfide-rich settings, relative to the more oxidizing habitats where mainly Fe(III)(oxyhydr)oxides are precipitated. In addition, a habitat-wide low As-respiring and As-oxidizing gene content relative to As resistance gene richness, suggests that As detoxification is prioritized over metabolic As cycling in the sediments. Collectively, the data point to redox control on Fe and S mineralization as a decisive factor in the regulation of high affinity phosphate uptake and As cycling gene content in shallow submarine hydrothermal ecosystems along the HVA. 相似文献
207.
Tran Cuong Duy Chu Ha Duc Nguyen Kien Huu Watanabe Yasuko La Hong Viet Tran Khanh Dang Tran Lam-Son Phan 《Journal of Plant Growth Regulation》2018,37(4):1286-1299
Journal of Plant Growth Regulation - Chickpea (Cicer arietinum L.) is regarded as one of the important grain legumes of the Fabaceae family and being consumed in many... 相似文献
208.
Cardiolipin (CL) is a complex phospholipid that is specifically found in mitochondria. Owing to the association of the CL levels with mitochondrial physiopathology such as in Parkinson’s disease, we study the molecular effect of CL on membrane organization using model Langmuir monolayer, fluorescence microscopy, and x-ray reflectivity. We find that the liquid-expanded phase in membranes increases with increasing CL concentration, indicating an increase in the elasticity of the mixed membrane. The Gibbs excess free energy of mixing indicates that the binary monolayer composed of CL and DPPC is most thermodynamically stable at ΦCL = 10 mol %, and the stability is enhanced when the surface pressure is increased. Additionally, when ΦCL is small, the expansion of the membrane with increasing CL content was slower at higher surface pressure. These abnormal results are indicative of a folding structure being present before a collapsing structure, which was confirmed by using fluorescence microscopy and was characterized by using x-ray reflectivity with the electron density profile along the membrane’s surface normal. 相似文献
209.
A subacute treatment of L-methionine induces an increase in the number of [3H]spiperone binding sites in the striatum of the rat 总被引:1,自引:0,他引:1
G Le Fur T Phan M C Burgevin A Flamier N Mitrani F Marquis C Jozefczak A Uzan 《Life sciences》1983,32(20):2321-2328
A subacute treatment, 500 mg/kg I.P. twice daily during 5 days, by L-methionine provoked an increase in the Bmax of [3H]-spiperone binding in the striatum of the rat. This increase was associated to a decrease in membrane microviscosity. However in these conditions no changes were found in the [3H]-DHA, [3H]QNB bindings or in the brain dopamine sensitive adenylate cyclase activity. L-methionine treatment reduced the accumulation of Dopa after NSD 1015 and antagonized the decrease in striatal acetylcholine provoked by haloperidol. Thus L-methionine might be a new potential drug for Parkinson's disease treatment. 相似文献
210.
Vimentin is one of the intermediate filaments that functions in structural support, signal transduction and organelle positioning of a cell. In the present study, we report the contribution of vimentin in mitochondrial morphology and organization. Using subcellular fractionation, immunoprecipitation and fluorescence microscopy analyses, we found that vimentin was associated with mitochondria. Knockdown of vimentin resulted in mitochondrial fragmentation, swelling and disorganization. We further demonstrated that the vimentin cytoskeleton co-localized and interacted with mitochondria to a greater extent than other cytoskeletal components known to support mitochondria. Our results also suggest that vimentin could participate in the mitochondrial association of microtubules. As mitochondrial morphologies determine mitochondrial function, our findings revealed a potentially important relationship between the vimentin-based intermediate filaments and the regulation of mitochondria. 相似文献