全文获取类型
收费全文 | 800篇 |
免费 | 52篇 |
出版年
2023年 | 6篇 |
2022年 | 5篇 |
2021年 | 8篇 |
2020年 | 10篇 |
2019年 | 7篇 |
2018年 | 11篇 |
2017年 | 7篇 |
2016年 | 17篇 |
2015年 | 30篇 |
2014年 | 31篇 |
2013年 | 38篇 |
2012年 | 56篇 |
2011年 | 46篇 |
2010年 | 33篇 |
2009年 | 30篇 |
2008年 | 49篇 |
2007年 | 54篇 |
2006年 | 60篇 |
2005年 | 59篇 |
2004年 | 44篇 |
2003年 | 34篇 |
2002年 | 33篇 |
2001年 | 9篇 |
2000年 | 7篇 |
1999年 | 10篇 |
1998年 | 9篇 |
1997年 | 9篇 |
1995年 | 9篇 |
1994年 | 13篇 |
1993年 | 13篇 |
1992年 | 14篇 |
1991年 | 9篇 |
1990年 | 7篇 |
1989年 | 12篇 |
1988年 | 10篇 |
1987年 | 6篇 |
1986年 | 4篇 |
1985年 | 4篇 |
1984年 | 4篇 |
1983年 | 5篇 |
1982年 | 5篇 |
1981年 | 2篇 |
1980年 | 7篇 |
1976年 | 2篇 |
1974年 | 2篇 |
1970年 | 1篇 |
1969年 | 2篇 |
1968年 | 1篇 |
1967年 | 1篇 |
1966年 | 1篇 |
排序方式: 共有852条查询结果,搜索用时 15 毫秒
171.
Differential occurrence of CSF-like activity and transforming activity of Mos during the cell cycle in fibroblasts. 总被引:4,自引:4,他引:0
下载免费PDF全文
![点击此处可从《The EMBO journal》网站下载免费的PDF全文](/ch/ext_images/free.gif)
The Xenopus c-mos proto-oncogene product, Mosxe, possesses cytostatic factor (CSF) activity to arrest maturing oocytes in metaphase II and has weak transforming activity in mouse NIH3T3 cells. We show that Mosxe mutants bearing 'stabilizing' penultimate N-terminal amino acids are strongly transforming and can retard progression through the G2-M phases in Mosxe-transformed cells, probably via their CSF activity. On the other hand, a cyclin-Mosxe fusion protein, which undergoes abrupt degradation at the end of mitosis and is restored to its normal levels only after the G1 phase, transforms cells much less efficiently than a mutated cyclin-Mosxe fusion protein that is stable during M-G1 transition. Moreover, in low-serum medium, cells transformed by the unstable cyclin-Mosxe require a long period to enter the S phase, in contrast with the rapid entry into the S phase of cells transformed by the stable cyclin-Mosxe. These results provide strong evidence that unlike the physiological CSF activity, the transforming activity of Mos is exerted in the G1 phase of the cell cycle. 相似文献
172.
Taku Wakabayashi Hisamichi Naito Jun-ichi Suehiro Yang Lin Hideya Kawaji Tomohiro Iba Tsukasa Kouno Sachi Ishikawa-Kato Masaaki Furuno Kazuhiro Takara Fumitaka Muramatsu Jia Weizhen Hiroyasu Kidoya Katsuhiko Ishihara Yoshihide Hayashizaki Kohji Nishida Mervin C. Yoder Nobuyuki Takakura 《Cell Stem Cell》2018,22(3):384-397.e6
173.
Tsuyoshi Shinozuka Tomoharu Tsukada Kunihiko Fujii Eri Tokumaru Kousei Shimada Yoshiyuki Onishi Yumi Matsui Satoko Wakimoto Masanori Kuroha Tsuneaki Ogata Kazushi Araki Jun Ohsumi Ryoko Sawamura Nobuaki Watanabe Hideki Yamamoto Kazunori Fujimoto Yoshiro Tani Makoto Mori Jun Tanaka 《Bioorganic & medicinal chemistry》2018,26(18):5079-5098
174.
175.
176.
177.
Ground crickets singing in volcanic warm “islets” in snowy winter: Their seasonal life cycles,photoperiodic responses and origin
下载免费PDF全文
![点击此处可从《Entomological Science》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Sinzo Masaki Masayuki Soma Hidenori Ubukata Haruo Katakura Rie Ichihashi Zhuqing He Nobuaki Ichijô Norio Kobayashi Makio Takeda 《Entomological Science》2016,19(4):416-431
The ground cricket Dianemobius nigrofasciatus overwinters as an egg in Japan, being univoltine in Hokkaido and northern Honshu and bivoltine farther south. In Hokkaido, however, this cricket is heard singing in winter in several fumarolic fields covered with moss and grasses locally known as “bokke”. In such warm “islets” the adult density was high in early summer and again in autumn, indicating that the cricket is bivoltine in contrast to the univoltine life cycle outside the bokke habitats in Hokkaido. Eggs laid by females collected at regular intervals from a bokke habitat showed a clear seasonal cycle of diapause incidence. At 26°C, the bokke strains produced non‐diapause eggs under long days and diapause eggs under short days as in the southern bivoltine populations, although the critical day‐length was longer than in the south. Several strains derived from non‐bokke habitats in Hokkaido and northern Honshu produced high percentages of diapause eggs under long days as well as short days as expected for the univoltine life cycle. Winter adults singing in bokke habitats could be either survivors of the autumn generation or individuals derived from eggs laid in autumn and then matured in response to the high soil temperature. In the laboratory, the proportion of egg diapause in short days was decreased by selection only for several generations. Phylogenetic trees of bokke and non‐bokke populations, based on both the nucleotide sequence of the mitochondrial COI gene and four allozyme loci, suggest that bokke populations have not been isolated from non‐bokke populations for an evolutionarily significant time. 相似文献
178.
179.
Characteristics of Glucose Transport in Neuronal Cells and Astrocytes from Rat Brain in Primary Culture 总被引:5,自引:4,他引:1
Masayuki Hara Yoshihiro Matsuda Keisuke Hirai Nobuaki Okumura Hachiro Nakagawa 《Journal of neurochemistry》1989,52(3):902-908
Glucose transport systems in cultured neuronal cells and astrocytes of rats were characterized by measuring the uptake of 2-deoxy-D-[3H]glucose ([3H]2-DG) into the cells. Various sugars inhibited 2-DG uptake by neuronal cells and astrocytes similarly, a finding indicating that the substrate specificities of the transporters in the two types of cells were almost the same. However, the Km values for 2-DG of neuronal cells and astrocytes were 1.7 and 0.36 mM, respectively. The uptake of 2-DG was strongly inhibited by cytochalasin B. Nucleosides, such as adenosine, inosine, and uridine, inhibited 2-DG uptake competitively in both neuronal cells and astrocytes. The uptake by both types of cells were also inhibited by forskolin, but not by cyclic AMP, an observation suggesting that forskolin bound directly to the transporters to cause inhibition. Its inhibition was competitive in astrocytes and noncompetitive in neuronal cells. Astrocytes contained a glucose transporter with a subunit molecular weight of 45K, as estimated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis after photoaffinity labeling using [3H]cytochalasin B as a probe. 相似文献
180.