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We propose an analytical model, which can simultaneously depict many fundamental characteristics of the immunogenicity of various vaccines. This model, the Immune Response (IR) profile, conveniently expresses the mathematical relation between pre- and post-vaccination titers. A vaccine's IR profile is antigen-specific, dose-dependent and post-vaccination interval-dependent. The maximal capability for serological response to a vaccine can be determined using this model irrespective of the dose administered, the post-vaccination assay interval, or the live or killed state of the vaccine. The IR profile obtained from analysis of booster vaccine responses in a limited number of seropositive study subjects can be used to predict maximal antibody titers which are expected after vaccination and can predict the geometric mean post-vaccination antibody titer of a cohort of subjects undergoing primary immunization. Using this model, it is anticipated that the immunoregulation implied by the IR profile may also prove to be correlated with cellular subpopulations and idiotypic antibody functions. Although derived from influenza vaccines analyses, the model successfully describes immune response characteristics following natural infection with malaria and following diphtheria and rubella vaccine administration. 相似文献
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The Flora of the Perivaginal Area: The Normal Flora and the Effect of a Deodorant Spray 总被引:1,自引:1,他引:0
Susan Crowley Catherine T. Murphy Pamela M. White W. C. Noble Elizabeth R. M. Rowell D. Bluett 《Journal of applied microbiology》1974,37(3):385-392
S ummary . The microbial flora of the thigh adjacent to the vaginal labia and of the mucosal surface of the labia has been examined quantitatively and qualitatively in students from Colleges of Education and a University, and in persons attending a Consultant Gynaecologist for non-suppurative conditions. In the 2 student populations, members of the Micrococcaceae and diphtheroids were the most common organisms but all populations yielded many organisms of gut origin. Differences between the populations may relate to social and hygienic conditions and should make us wary of direct comparisons with other, different populations. The effect of intimate hygiene deodorants containing 0.01% or 0.02% of chlorhexidine was compared with a base spray containing no antibacterial agent. No significant effect of these sprays on the microbial flora could be demonstrated. 相似文献
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Rebecca E. Koch Katherine L. Buchanan Stefania Casagrande Ondi Crino Damian K. Dowling Geoffrey E. Hill Wendy R. Hood Matthew McKenzie Mylene M. Mariette Daniel W.A. Noble Alexandra Pavlova Frank Seebacher Paul Sunnucks Eve Udino Craig R. White Karine Salin Antoine Stier 《Trends in ecology & evolution》2021,36(4):321-332
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Andrew Harrison Hans Binder Arnaud Buhot Conrad J. Burden Enrico Carlon Cynthia Gibas Lara J. Gamble Avraham Halperin Jef Hooyberghs David P. Kreil Rastislav Levicky Peter A. Noble Albrecht Ott B. Montgomery Pettitt Diethard Tautz Alexander E. Pozhitkov 《Nucleic acids research》2013,41(5):2779-2796
Hybridization of nucleic acids on solid surfaces is a key process involved in high-throughput technologies such as microarrays and, in some cases, next-generation sequencing (NGS). A physical understanding of the hybridization process helps to determine the accuracy of these technologies. The goal of a widespread research program is to develop reliable transformations between the raw signals reported by the technologies and individual molecular concentrations from an ensemble of nucleic acids. This research has inputs from many areas, from bioinformatics and biostatistics, to theoretical and experimental biochemistry and biophysics, to computer simulations. A group of leading researchers met in Ploen Germany in 2011 to discuss present knowledge and limitations of our physico-chemical understanding of high-throughput nucleic acid technologies. This meeting inspired us to write this summary, which provides an overview of the state-of-the-art approaches based on physico-chemical foundation to modeling of the nucleic acids hybridization process on solid surfaces. In addition, practical application of current knowledge is emphasized. 相似文献
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Michael B. Miller Daphne W. Wang Fei Wang Geoffrey P. Noble Jiyan Ma Virgil L. Woods Sheng Li Surachai Supattapone 《Structure (London, England : 1993)》2013,21(11):2061-2068
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