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Discovery of a Class of Endogenous Mammalian Lipids with Anti-Diabetic and Anti-inflammatory Effects 总被引:1,自引:0,他引:1
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Fernanda N. Valentin Laura S. O. Nakaghi Srgio R. Batlouni Nivaldo F. do Nascimento Maria do Carmo Faria Paes Regiane Cristina da Silva Breno Manzini Sheryll Yohana Corchuelo Chavarro Marcelo Henrique Correa Assuno 《Zeitschrift fur angewandte Ichthyologie》2019,35(2):529-540
In the species Pseudoplatystoma fasciatum the males are smaller than females. Thus, the objective of this study was to describe the process of testicular differentiation and provide tools for sex manipulation techniques aimed at improving the productivity of farming of sexually‐reversed females. Correlation between the length, age, sex rate and the stage of gonadal development were analyzed in this species from samples collected between 0 and 240 days post‐hatching. Testicular differentiation was divided into eight stages, based on the cellular and morphological characteristics of the gonad. The results showed that sexual differentiation has a greater correlation to the size than the age in this species. This study provides knowledge on the proliferation and distinctive arrangement of somatic cells, which enabled the early identification of the testis due to the presence of future fringes in the specimens. Testicular differentiation in P. fasciatum was histologically different from other species due to the proliferation and distribution of somatic cells in the regions that would originate the testicular tubules and sperm ducts. Meiosis began at a later stage in comparison with other species, therefore, it was not considered a criterion for early sexual characterization. It can be concluded that testicular differentiation in P. fasciatum occurs relatively early and this data can be used to improve sex inversion protocols and increase productivity in this species. 相似文献
85.
Lessa JA Guerra JC de Miranda LF Romeiro CF Da Silva JG Mendes IC Speziali NL Souza-Fagundes EM Beraldo H 《Journal of inorganic biochemistry》2011,105(12):1729-1739
Complexes [Au(H2Ac4DH)Cl]?MeOH (1) [Au(H22Ac4Me)Cl]Cl (2) [Au(H22Ac4Ph)Cl]Cl?2H2O (3) and [Au(H22Bz4Ph)Cl]Cl (4) were obtained with 2-acetylpyridine thiosemicarbazone (H2Ac4DH), its N(4)-methyl (H2Ac4Me) and N(4)-phenyl (H2Ac4Ph) derivatives, as well as with N(4)-phenyl 2-benzoylpyridine thiosemicarbazone (H2Bz4Ph). The compounds were cytotoxic to Jurkat (immortalized line of T lymphocyte), HL-60 (acute myeloid leukemia), MCF-7 (human breast adenocarcinoma) and HCT-116 (colorectal carcinoma) tumor cell lines. Jurkat and HL-60 cells were more sensitive than MCF-7 and HCT-116 cells. Upon coordinating to the gold(I) metal centers in complexes (2) and (4), the cytotoxic activity of the H2Ac4Me and H2Bz4Ph ligands increased against the HL-60 and Jurkat tumor cell lines. 2 was more active than auranofin against both leukemia cells. Most of the studied compounds were less toxic than auranofin to peripheral blood mononuclear cells (PBMC). All compounds induced DNA fragmentation in HL-60 and Jurkat cells indicating their pro-apoptotic potential. Complex (2) strongly inhibited the activity of thioredoxin reductase (TrxR), which suggests inhibition of TrxR to be part of its mechanism of action. 相似文献
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James A. Fuller Aimee Summers Mark A. Katz Kim A. Lindblade Henry Njuguna Wences Arvelo Sammy Khagayi Gideon Emukule Nivaldo Linares-Perez John McCracken D. James Nokes Mwanajuma Ngama Sidi Kazungu Joshua A. Mott Sonja J. Olsen Marc-Alain Widdowson Daniel R. Feikin 《PloS one》2013,8(2)
Background
Knowing the national disease burden of severe influenza in low-income countries can inform policy decisions around influenza treatment and prevention. We present a novel methodology using locally generated data for estimating this burden.Methods and Findings
This method begins with calculating the hospitalized severe acute respiratory illness (SARI) incidence for children <5 years old and persons ≥5 years old from population-based surveillance in one province. This base rate of SARI is then adjusted for each province based on the prevalence of risk factors and healthcare-seeking behavior. The percentage of SARI with influenza virus detected is determined from provincial-level sentinel surveillance and applied to the adjusted provincial rates of hospitalized SARI. Healthcare-seeking data from healthcare utilization surveys is used to estimate non-hospitalized influenza-associated SARI. Rates of hospitalized and non-hospitalized influenza-associated SARI are applied to census data to calculate the national number of cases. The method was field-tested in Kenya, and validated in Guatemala, using data from August 2009–July 2011. In Kenya (2009 population 38.6 million persons), the annual number of hospitalized influenza-associated SARI cases ranged from 17,129–27,659 for children <5 years old (2.9–4.7 per 1,000 persons) and 6,882–7,836 for persons ≥5 years old (0.21–0.24 per 1,000 persons), depending on year and base rate used. In Guatemala (2011 population 14.7 million persons), the annual number of hospitalized cases of influenza-associated pneumonia ranged from 1,065–2,259 (0.5–1.0 per 1,000 persons) among children <5 years old and 779–2,252 cases (0.1–0.2 per 1,000 persons) for persons ≥5 years old, depending on year and base rate used. In both countries, the number of non-hospitalized influenza-associated cases was several-fold higher than the hospitalized cases.Conclusions
Influenza virus was associated with a substantial amount of severe disease in Kenya and Guatemala. This method can be performed in most low and lower-middle income countries. 相似文献87.
Thelma L. P. Dias Nivaldo A. Leo Neto Rômulo R. N. Alves 《Biodiversity and Conservation》2011,20(11):2393-2405
Marine molluscs are sold all over the world as curios and souvenirs. This market encompasses about 5,000 species of molluscs
(bivalves and gastropods) worldwide, but the mollusc species involved in this trade are undocumented in all but a very small
number of countries. The present study provides a baseline assessment of the mollusc species used in the manufacture of crafts,
marine curiosities and souvenirs in northeastern Brazil. A total of 126 species (41 bivalves and 85 gastropods) were found
to be sold individually as decorative pieces or incorporated into utilitarian objects. Overall, the families most represented
were Veneridae bivalves (9 species) and the gastropods Conidae and Strombidae (8 species each). Large gastropod shells were
observed in all of the localities surveyed (mainly as part of table lamps). The main species used were the King helmet Cassis tuberosa, the Hebrew volute Voluta ebraea, and the Goliath conch Eustrombus goliath. The majority of the species involved are harvested from the Atlantic Ocean (68%), but many are imported from Indo-Pacific
countries, such as cowries Monetaria moneta. Among the species harvested in the Atlantic Ocean, 11.2% are endemic to Brazil as, for example, the Brazilian chank (Turbinella laevigata). The majority of the species sold in northeastern Brazil tend to inhabit shallow habitats, which facilitates their capture.
As there are no official statistics available concerning the marine curio and souvenir trade in Brazil, some species may be
endangered. Harvesting regulations should include minimum capture sizes, capture quotas, specific periods for harvesting,
and the use of non-destructive techniques. 相似文献
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José Ribamar Sousa Júnior Ulysses Paulino Albuquerque Nivaldo Peroni 《Economic botany》2013,67(3):225-233
Traditional Knowledge and Management of Caryocar coriaceum Wittm. ( Pequi ) in the Brazilian Savanna, Northeastern Brazil Caryocar coriaceum Wittm. (pequi) is a tree native to northeastern Brazil that produces fruits of importance to human populations of the region. This species serves as a resource for the livelihoods of many people and represents a source of income in many rural communities in northeastern Brazil. This study aimed to evaluate the knowledge, use, collection practices, and forms of local management related to C. coriaceum in a rural community in the state of Ceará, Chapada do Araripe, northeast Brazil. Pequi collectors were identified and constituted the sample of respondents (N = 56). The knowledge of C. coriaceum is uniformly distributed in the community. The categories food and derivatives (oil) were the most relevant. Considering all use categories, there was a significant difference between the knowledge of men and women (p <0.05, 95% confidence interval) based on the Shannon-Wiener and Hurlbert’s PIE diversity indices. The main form of management applied to pequi trees was collection of its fruits, followed by the practice locally referred to as zelar (similar to the management practice “protection”) and sowing seeds. All of the informants stated that they commercialize pequi fruits. The mean income from fruit sales is less than the mean income obtained via selling pequi oil, as the latter product is of greater commercial value. Among the nine most relevant collection sites, Barreiro Novo (savanna) was highlighted, which is part of both a protected area and the anthropogenic landscape of the region, and has great economic and cultural importance for pequi collectors. 相似文献
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Cristiana Barbosa Francisco I. Pugnaire Nivaldo Peroni Tânia Tarabini Castellani 《Plant Ecology》2018,219(7):813-821
Global warming is expected to cause significant changes in the distribution of species worldwide, altering ecosystem function and services. These impacts can be exacerbated by synergism with other global change drivers, such as biological invasions. Furcraea foetida (Asparagaceae) is a CAM species native to Central America and northern South America that is currently invading coastal ecosystems in the Atlantic Forest biome in Brazil. The species propagates clonally by bulbils, forming dense clusters that exclude native species. We addressed whether warming may favor or impair development of F. foetida bulbils based on functional traits and assessed whether plant cover of native species influenced F. foetida establishment in a rocky shore ecosystem. We used open-top chambers during summer and autumn, which increased air temperature during daylight hours by 0.4 °C relative to ambient conditions. This short-term warming effect increased the leaf length of bulbils but had no effect on number of leaves, dry mass, specific leaf area, leaf dry matter content (LDMC), or photosynthetic efficiency of photosystem II (Fv/Fm). However, an increase in vegetation cover decreased LDMC and helped maintain high Fv/Fm, having an indirect positive effect on F. foetida establishment that suggests a facilitation interaction in this extreme environment. Even though the manipulated temperature did not reach IPCC (Intergovernmental Panel on Climate Change) forecasts for 2100, our data show that even small, short-term changes in temperature affected plant performance. Thus, we suggest that F. foetida may be favored in a scenario of climate change, increasing its negative effects on biodiversity of coastal ecosystems. 相似文献
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Ismail Syed Jennifer Lee Pedro M. Moraes-Vieira Cynthia J. Donaldson Alexandra Sontheimer Pratik Aryal Kerry Wellenstein Matthew J. Kolar Andrew T. Nelson Dionicio Siegel Jacek Mokrosinski I. Sadaf Farooqi Juan Juan Zhao Mark M. Yore Odile D. Peroni Alan Saghatelian Barbara B. Kahn 《Cell metabolism》2018,27(2):419-427.e4