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排序方式: 共有758条查询结果,搜索用时 124 毫秒
751.
752.
G L Sharma V K Vinayak S R Naik 《Journal of hygiene, epidemiology, microbiology, and immunology》1984,28(4):471-478
Immunologically potent, RNA protein fraction could be isolated from axenic Entamoeba histolytica (NIH: 200) using a phenol extraction method. Immunization of animals with amoebal RNA protein (Eh RNA) fraction evoked an intense cellular sensitization. In immunized animals the percent leucocyte migration inhibition was found to be 73.7 +/- 6.9. In control groups where the animals were treated with Freund's complete adjuvant, yeast RNA and amoebal RNA treated with RNase, the percent leucocyte migration inhibition was 15.8 +/- 2.9, 16.8 +/- 6.2 and 14.0 +/- 4.0 respectively. Anti Eh RNA antibodies (haemagglutinins and precipitins) could not be demonstrated in immunized animals at any stage of observations. The cellular immunity could be maintained at its high level by giving three immunization doses of Eh RNA and also a high degree (95.45%) of protection against experimental challenge with virulent strain of E. histolytica could be obtained in immunized animals. The immunogenic and protective capabilities of Eh RNA were found to be specific since they were abolished by the RNase treatment. Further, the yeast RNA failed to elicit immunity. 相似文献
753.
A M Mujumdar J N Dhuley V K Deshmukh P H Raman S R Naik 《Japanese journal of medical science & biology》1990,43(3):95-100
Piperine (1-peperoyl piperidine) was isolated from Piper nigrum Linn for the evaluation of anti-inflammatory activity in rats. Different acute and chronic experimental models like carrageenin-induced rat paw edema, cotton pellet granuloma, and croton oil-induced granuloma pouch, were employed. Simultaneously, biochemical estimations were made to elucidate the underlying mechanism of the action. Piperine acted significantly on early acute changes in inflammatory processes and chronic granulative changes. It also acted partially through stimulation of pituitary adrenal axis. Exudative changes in both acute and chronic models, however, were insignificant. 相似文献
754.
755.
1,2-Dihydrosantonin is the first stable product in the degradative pathway of alpha-santonin by Pseudomonas cichorii S. Its formation is catalyzed by an oxidoreductase, which is NADH or NADPH dependent and has an apparent Km value of 66.66 microM for santonin and 44.33 microM for NADH. The enzyme activity is stable at pH 6.0, 7.0, and 8.0, and is not affected by EDTA and divalent metal ions. It is postulated that the enzymic reduction of santonin occurs via formation of a transient zwitterionic intermediate, which undergoes nonenzymatic 1,4-sigmatropic rearrangement to yield lumisantonin during the solvent extraction process. Lumisantonin is, thus, not a true metabolic intermediate but an artifact. 相似文献
756.
Rajeev M. Naik 《Journal of plant biochemistry and biotechnology.》2007,16(1):67-69
Loss of major mitochondrial complex I subunit Nad 7 in the leaves of CMS II mutant of Nicotiana sylvestris caused increase in both in vivo and in vitro nitrate reductase activities and the per cent activation state of NR was also higher in CMS II as against wild type. The differences suggest a possibility for export of mitochondrial NADH due to impairment of complex I, a major and high affinity sink for NADH. Loss of complex I subunit also resulted in constitutive expression of alternate oxidase (Aox) thereby providing a mechanism for continuous supply of carbon skeletons required for nitrate assimilation. The possibility of close coordination between mitochondrial redox perturbation and nitrate reduction and its further assimilation is discussed. 相似文献
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758.