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排序方式: 共有191条查询结果,搜索用时 15 毫秒
91.
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Santiago Roura Juli R. Bagó Carolina Soler-Botija Josep M. Pujal Carolina Gálvez-Montón Cristina Prat-Vidal Aida Llucià-Valldeperas Jerónimo Blanco Antoni Bayes-Genis 《PloS one》2012,7(11)
Stem cell therapies are promising strategies to regenerate human injured tissues, including ischemic myocardium. Here, we examined the acquisition of properties associated with vascular growth by human umbilical cord blood-derived mesenchymal stem cells (UCBMSCs), and whether they promoted vascular growth in vivo. UCBMSCs were induced in endothelial cell-specific growth medium (EGM-2) acquiring new cell markers, increased Ac-LDL uptake, and migratory capacity as assessed by qRT-PCR, Western blotting, indirect immunofluorescence, and invasion assays. Angiogenic and vasculogenic potentials could be anticipated by in vitro experiments showing self organization into Matrigel-mediated cell networks, and activation of circulating angiogenic-supportive myeloid cells. In mice, following subcutaneous co-injection with Matrigel, UCBMSCs modified to co-express bioluminescent (luciferases) and fluorescent proteins were demonstrated to participate in the formation of new microvasculature connected with the host circulatory system. Response of UCBMSCs to ischemia was explored in a mouse model of acute myocardial infarction (MI). UCBMSCs transplanted using a fibrin patch survived 4 weeks post-implantation and organized into CD31+network structures above the infarcted myocardium. MI-treated animals showed a reduced infarct scar and a larger vessel-occupied area in comparison with MI-control animals. Taken together, the presented results show that UCBMSCs can be induced in vitro to acquire angiogenic and vasculogenic properties and contribute to vascular growth in vivo. 相似文献
93.
Studies on a phosphoenol pyruvate hexose phosphotransferase system in Vibrio cholerae 总被引:1,自引:0,他引:1
J Bag 《Indian journal of biochemistry & biophysics》1973,10(4):257-260
94.
Formation of nuclear inclusions consisting of aggregates of a polyalanine expansion mutant of nuclear poly(A)-binding protein (PABPN1) is the hallmark of oculopharyngeal muscular dystrophy (OPMD). OPMD is a late onset autosomal dominant disease. Patients with this disorder exhibit progressive swallowing difficulty and drooping of their eye lids, which starts around the age of 50. Previously we have shown that treatment of cells expressing the mutant PABPN1 with a number of chemicals such as ibuprofen, indomethacin, ZnSO4, and 8-hydroxy-quinoline induces HSP70 expression and reduces PABPN1 aggregation. In these studies we have shown that expression of additional HSPs including HSP27, HSP40, and HSP105 were induced in mutant PABPN1 expressing cells following exposure to the chemicals mentioned above. Furthermore, all three additional HSPs were translocated to the nucleus and probably helped to properly fold the mutant PABPN1 by co-localizing with this protein. 相似文献
95.
Bag Sagar Mondal Anupam Majumder Anusha Mondal Sunil Kanti Banik Avishek 《Phytochemistry Reviews》2022,21(5):1739-1760
Phytochemistry Reviews - Plants generate a wide variety of organic components during their different growth phases. The majority of those compounds have been classified as primary and secondary... 相似文献
96.
Dobolyi Arpád Bagó Attila G. Gál Aniko Molnár Mária J. Palkovits Miklós Adam-Vizi Vera Chinopoulos Christos 《Journal of bioenergetics and biomembranes》2015,47(1-2):33-41
Journal of Bioenergetics and Biomembranes - We have recently shown that the ATP-forming SUCLA2 subunit of succinyl-CoA ligase, an enzyme of the citric acid cycle, is exclusively expressed in... 相似文献
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Development and characterization of genomic and expressed SSRs for levant cotton (Gossypium herbaceum L.) 总被引:2,自引:0,他引:2