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701.
702.
Cranberry flavonoids prevent toxic rat liver mitochondrial damage in vivo and scavenge free radicals in vitro 下载免费PDF全文
Elena A. Lapshina Maria Zamaraeva Vitali T. Cheshchevik Ewa Olchowik‐Grabarek Szymon Sekowski Izabela Zukowska Nina G. Golovach Vasili N. Burd Ilya B. Zavodnik 《Cell biochemistry and function》2015,33(4):202-210
The present study was undertaken for further elucidation of the mechanisms of flavonoid biological activity, focusing on the antioxidative and protective effects of cranberry flavonoids in free radical‐generating systems and those on mitochondrial ultrastructure during carbon tetrachloride‐induced rat intoxication. Treatment of rats with cranberry flavonoids (7 mg/kg) during chronic carbon tetrachloride‐induced intoxication led to prevention of mitochondrial damage, including fragmentation, rupture and local loss of the outer mitochondrial membrane. In radical‐generating systems, cranberry flavonoids effectively scavenged nitric oxide (IC50 = 4.4 ± 0.4 µg/ml), superoxide anion radicals (IC50 = 2.8 ± 0.3 µg/ml) and hydroxyl radicals (IC50 = 53 ± 4 µg/ml). The IC50 for reduction of 1,1‐diphenyl‐2‐picrylhydrazyl radicals (DPPH) was 2.2 ± 0.3 µg/ml. Flavonoids prevented to some extent lipid peroxidation in liposomal membranes and glutathione oxidation in erythrocytes treated with UV irradiation or organic hydroperoxides as well as decreased the rigidity of the outer leaflet of the liposomal membranes. The hepatoprotective potential of cranberry flavonoids could be due to specific prevention of rat liver mitochondrial damage. The mitochondria‐addressed effects of flavonoids might be related both to radical‐scavenging properties and modulation of various mitochondrial events. Copyright © 2015 John Wiley & Sons, Ltd. 相似文献
703.
Biljana Stojković Darka Šešlija Jovanović Jelena Perovanović Nikola Tucić 《Ethology : formerly Zeitschrift fur Tierpsychologie》2011,117(9):812-821
We evaluated the degree of reproductive isolation between laboratory populations of the seed beetle (Acanthoscelides obtectus) selected to reproduce early (E) or late (L) in life, where different levels of sexual activity and sexual discrimination have been detected. We found a significant level of behavioral isolation among populations within the E selection regime in which beetles showed enhanced early‐life fitness traits and low sexual activity. In contrast, substantially higher levels of sexual activity and an indiscriminate mating system inhibited rather than promoted pre‐zygotic isolation between the L populations. Our results indicate that the study of sexual activity levels may be crucial for understanding the first steps in the pre‐zygotic isolation among allopatric populations subjected to uniform selection. 相似文献
704.
Development Genes and Evolution - 相似文献
705.
Christopher Burton Hans Knoop Nikola Popovic Michael Sharpe Gijs Bleijenberg 《BioPsychoSocial medicine》2009,3(1):1-9