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Calistus N. Ngonghala Miranda I. Teboh-Ewungkem Gideon A. Ngwa 《Theoretical Ecology》2016,9(3):337-351
We illustrate that an autonomous ordinary differential equation model for malaria transmission can exhibit period-doubling bifurcations leading to chaos when ecological aspects of malaria transmission are incorporated into the model. In particular, when demography, feeding, and reproductive patterns of the mosquitoes that transmit the malaria-causing parasite are explicitly accounted for, the resulting model exhibits subcritical bifurcations, period-doubling bifurcations, and chaos. Vectorial and disease reproduction numbers that regulate the size of the vector population at equilibrium and the endemicity of the malaria disease, respectively, are identified and used to simulate the model to show the different bifurcations and chaotic dynamics. A subcritical bifurcation is observed when the disease reproduction number is less than unity. This highlights the fact that malaria control efforts need to be long lasting and sustained to drive the infectious populations to levels below the associated saddle-node bifurcation point at which control is feasible. As the disease reproduction number increases beyond unity, period-doubling cascades that develop into chaos closely followed by period-halving sequences are observed. The appearance of chaos suggests that characterization of the physiological status of disease vectors can provide a pathway toward understanding the complex phenomena that are known to characterize the dynamics of malaria and other indirectly transmitted infections of humans. To the best of our knowledge, there is no known unforced continuous time deterministic host-vector transmission malaria model that has been shown to exhibit chaotic dynamics. Our results suggest that malaria data may need to be critically examined for complex dynamics. 相似文献
84.
AS Glen D Anderson CJ Veltman PM Garvey M Nichols 《New Zealand journal of zoology.》2016,43(2):127-137
A major challenge in controlling overabundant wildlife is monitoring their populations, particularly as they decline to very low density. Camera traps and wildlife detector dogs are increasingly being used for this purpose. We compared the cost-effectiveness of these two approaches for detecting feral cats (Felis catus) on two pastoral properties in Hawke's Bay, North Island, New Zealand. One property was subject to intensive pest removal, while the other had no recent history of pest control. Camera traps and wildlife detector dogs detected cats at similar rates at both sites. The operating costs of each method were also comparable. We identify a number of advantages and disadvantages of each technique, and suggest priorities for further research. 相似文献
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TD Smith KP Bhatnagar CJ Bonar KL Shimp MP Mooney MI Siegel 《American journal of physical anthropology》2003,122(3):301-301
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CJ Cooksey 《Biotechnic & histochemistry》2017,92(5):347-356
Methylene blue was synthesized in 1877 and soon found application in medicine, staining for microscopy and as an industrial dye and pigment. An enormous literature has accumulated since its introduction. Early on, it was known that methylene blue could be degraded easily by demethylation; consequently, the purity of commercial samples often was low. Therefore, demethylation products, such as azures and methylene violet, also are considered here. The names and identity of the components, their varying modes of manufacture, analytical methods and their contribution to biological staining are discussed. 相似文献
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A report of the ESF-EMBO Symposium Bacterial Networks (BacNet08), Sant Feliu de Guixols, Spain, 13-18 September 2008. 相似文献
88.
Complement proteins in blood recognize charged particles. The anionic phospholipid (aPL) cardiolipin binds both complement proteins C1q and factor H. C1q is an activator of the complement classical pathway, while factor H is an inhibitor of the alternative pathway. To examine opposing effects of C1q and factor H on complement activation by aPL, we surveyed C1q and factor H binding, and complement activation by aPL, either coated on microtitre plates or in liposomes. Both C1q and factor H bound to all aPL tested, and competed directly with each other for binding. All the aPL activated the complement classical pathway, but negligibly the alternative pathway, consistent with accepted roles of C1q and factor H. However, in this system, factor H, by competing directly with C1q for binding to aPL, acts as a direct regulator of the complement classical pathway. This regulatory mechanism is distinct from its action on the alternative pathway. Regulation of classical pathway activation by factor H was confirmed by measuring C4 activation by aPL in human sera in which the C1q:factor H molar ratio was adjusted over a wide range. Thus factor H, which is regarded as a down-regulator only of the alternative pathway, has a distinct role in downregulating activation of the classical complement pathway by aPL. A factor H homologue, β2-glycoprotein-1, also strongly inhibits C1q binding to cardiolipin. Recombinant globular domains of C1q A, B and C chains bound aPL similarly to native C1q, confirming that C1q binds aPL via its globular heads. 相似文献
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Susanne Mueller Asa Wahlander Nathalie Selevsek Claudia Otto Elsy Mankah Ngwa Kristina Poljak Alexander D. Frey Markus Aebi Robert Gauss 《Molecular biology of the cell》2015,26(14):2596-2608
Protein degradation is essential for cellular homeostasis. We developed a sensitive approach to examining protein degradation rates in Saccharomyces cerevisiae by coupling a SILAC approach to selected reaction monitoring (SRM) mass spectrometry. Combined with genetic tools, this analysis made it possible to study the assembly of the oligosaccharyl transferase complex. The ER-associated degradation machinery compensated for disturbed homeostasis of complex components by degradation of subunits in excess. On a larger scale, protein degradation in the ER was found to be a minor factor in the regulation of protein homeostasis in exponentially growing cells, but ERAD became relevant when the gene dosage was affected, as demonstrated in heterozygous diploid cells. Hence the alleviation of fitness defects due to abnormal gene copy numbers might be an important function of protein degradation. 相似文献
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