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981.
Cornacini Maiara R. Manoel Ricardo O. Alcantara Marcelo A. M. Moraes Mário L. T. Silva Edvaldo A. A. Pereira Neto Leonel G. Sebbenn Alexandre M. Rossini Bruno C. Marino Celso L. 《Molecular biology reports》2021,48(4):3165-3172
Molecular Biology Reports - Astronium fraxinifolium is an endangered tree species from Brazil. Due to its significance in environmental reforestation, as well as the continued exploitation of its... 相似文献
982.
Vanderlei Biolchi Brasil Silva Neto Diego Bromfman Pianta Walter José Koff Milton Berger Ilma Simoni Brum 《Molecular biology reports》2013,40(3):2749-2756
Polymorphic GGC repeats in the androgen receptor (AR) gene can alter transactivation of androgen-responsive genes and increase the risk of benign prostatic hyperplasia (BPH) and prostate cancer (PCa). We investigated the association between GGC repeat length, testosterone levels and the risk of developing PCa and BPH in a population from southern Brazil. A sample comprising 130 PCa, 126 BPH and 88 control patients was evaluated. DNA was extracted from leukocytes and the AR gene was analyzed by fragment analysis. The hazard ratio (HR) was estimated. GGC mean length was not different between the three study groups. The risk of developing PCa in individuals with GGC > 19 was 3.300 (95 %CI 1.385–7.874) higher when compared to the GGC ≤ 19 group (p = 0.007). The risk of developing PCa and BPH in individuals with total testosterone levels <4 ng/mL was 2.799 (95 % CI 1.362–5.754). (p = 0.005) and 2.786 (95 % CI 1.470–5.280) (p = 0.002), respectively. Total testosterone levels in patients with GGC > 19 were significantly lower when compared to patients in the GGC ≤ 19 group. Our data suggest that the presence of a high number of polymorphic GGC repeats in the AR gene is associated with an increased risk of developing PCa and BPH, and that lower testosterone levels also increase the risk of developing these diseases. 相似文献
983.
984.
985.
Lectoypifications of four species of Pseudolaelia Porto & Brade are presented as a result of an ongoing taxonomic revision of the genus. 相似文献
986.
987.
S Zucoloto J A Diaz J S Oliveira G Muccilo V N Sales Neto J K Kajiwara 《Cell and tissue kinetics》1988,21(4):213-219
The duodenum or descending colon of male Wistar rats (average weight 60 g) was treated by a serosal application of a 0.2% solution of benzalkonium chloride (BAC) for 30 min. Control animals were treated with 0.9% (physiological) saline. The rats were allocated to four groups: Group DC (N = 8) in which the duodenum was treated with physiological saline; Group DB (N = 8) in which the duodenum was treated with BAC; Group CC (N = 7) in which the descending colon was treated with physiological saline and Group CB (N = 7) in which the descending colon was treated with BAC. After treatment, the animals were followed up for 5 months. At the end of the experiment, the animals were injected intraperitoneally with vincristine sulphate before sacrifice. Three segments were removed from the duodenum and descending colon for neuronal counting, catecholamine and serotonin measurements and morphokinetic studies of the epithelium. The following results were obtained: (1) there was a significant reduction in neurone number in the myenteric plexus of segments treated with BAC; (2) in the denervated intestinal segments, catecholamine levels were unchanged whereas serotonin levels were increased; (3) epithelial hyperplasia was observed in the denervated duodenum and descending colon; and (4) crypt cell production rate in the duodenum was similar in groups DC and DB but was significantly increased in the descending colon in group CB as compared with controls (CC). The present findings indicate that selective myenteric neuronal denervation caused by benzalkonium chloride plays a causative role in the hyperplasia and crypt cell production rate of the intestinal epithelium (duodenum and descending colon). These changes are probably induced by functional imbalance by the surviving neuronal elements in the gut, implicating neurotransmitters such as acetylcholine, noradrenaline, serotonin, somatostatin and vasoactive intestinal peptide. 相似文献
988.
989.
Quan Yuan Jose D. Fontenele‐Neto Lloyd D. Fricker 《Obesity (Silver Spring, Md.)》2004,12(7):1179-1188
Objective: To compare the effect of voluntary exercise on body weight, food consumption, and levels of serum proteins between wild‐type and carboxypeptidase E‐deficient (Cpefat/fat) mice. Research Methods and Procedures: Study 1 consisted of three groups of female mice: Cpefat/fat mice with continuous access to exercise wheels for 3 weeks (n = 4); wild‐type C57BKS mice with access to exercise wheels for 3 weeks (n = 4); and sedentary Cpefat/fat mice (n = 3). Activity, body weight, and food consumption were monitored for this period and a subsequent 9‐week period without exercise wheels. Study 2 consisted of four groups of male mice (n = 6 to 7 each): Cpefat/fat mice with exercise wheels, wild‐type mice with exercise wheels, and Cpefat/fat and wild‐type mice without exercise wheels. Body weight and food consumption were measured over 4 weeks. Sera were collected, and the protein profile was determined by 2‐dimensional gel electrophoresis and mass spectrometry. Results: Cpefat/fat mice were moderately hyperphagic but lost weight during the initial exercise period because of greater energy expenditure. The effect of exercise was temporary, and the mice gained weight after the second week. Several serum proteins were found to be altered by exercise: haptoglobin was decreased by exercise in Cpefat/fat mice, and several kallikreins were increased by exercise in wild‐type mice. Discussion: The access to exercise wheels provided an initial weight loss in Cpefat/fat mice, but this effect was offset by elevated food consumption. The serum proteomics results indicated that Cpefat/fat and wild‐type mice differed in their response to exercise. 相似文献
990.
Patrícia IS Pinto Pratap B Singh João B Condeça Helena R Teodósio Deborah M Power Adelino VM Canário 《Reproductive biology and endocrinology : RB&E》2006,4(1):67-11