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51.
Baturina GS Isaeva LE Khodus GR Nesterov VV Solenov EI Ivanova LN 《Rossi?skii fiziologicheski? zhurnal imeni I.M. Sechenova / Rossi?skaia akademiia nauk》2004,90(7):865-873
Water permeability of the basolateral membrane was estimated in isolated fragments of OMCD or IMCD in the Wistar rats. Apical surface of the fragments was blocked with oil injected into the lumen. Apparent water permeability coefficient (Pf) was measured by the rate of epithelium swelling following transition from hypertonic to isotonic medium (600 mOsm to 300 mOsm). Water deprivation caused significant increase in the Pf value in OMCD and IMCD fragments. Desmopressin (10(-8) M) increased water permeability in hydrated rats both in OMCD and IMCD. Mercury chloride decreased the Pf and abolished the effect of desmopressin in reversible manner. Estimation of aquaporins 2, 3, 4 mRNA content in the renal medulla was performed by semi-quantitative RT-PCR. Content of AQP4 and AQP2 mRNA in dehydrated animals was significantly higher than in hydrated ones both in outer medulla and inner medulla. Expression of AQP3 increased during dehydration only in the inner medulla. The findings reveal that water permeability of OMCD and IMCD can be increased by physiological stimuli, e.g. water deprivation. The activation of gene expression of the key elements of vasopressin signal system seems to contribute to this reaction. 相似文献
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The relationship between shortening velocity and the applied external load (force-velocity) was studied for vena cava posterior of the frog Rana temporaria. This relationship was determined in 15 s, 2 and 20 min after the beginning of isometric contraction induced by a high KCl concentration (110 mmole/l). It was found that maximal shortening velocity (V
0) was the highest at the 15th s after the beginning of the isometric contraction and amounted to 0.125 ± 0.009 L
0/s (n = 4); then it decreased progressively to 0.058 ± 0.005 L
0/s at the 20th min, respectively. On the contrary, the isometric tension value increased and reached its peak in 5 min after the beginning of contraction, then it decreased slightly. Such phenomenon indicates the occurrence of attached non-cycling bridges. The a/P
0 parameter was equal to 0.15 ± 0.03 and 0.33 ± 0.06 at the 15th s and the 20th min, respectively. 相似文献
56.
Korotkov S. M. Sobol K. V. Shemarova I. V. Nesterov V. P. 《Journal of Evolutionary Biochemistry and Physiology》2021,57(6):1241-1250
Journal of Evolutionary Biochemistry and Physiology - The effect of calcium load on rat heart mitochondria [RHM(K+)], in which K+ ions in the matrix were partially replaced by Na+ ions [RHM(Na+)],... 相似文献
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Shemarova IV Korotkov SM Nesterov VP 《Zhurnal evoliutsionno? biokhimii i fiziologii》2011,47(4):306-310
The inotropic Cd2+ action on frog heart is studied with taking into account its toxic effects upon mitochondria. Cd2+ at concentrations of 1, 10, and 20 microM is established to decrease dosedependently (21.3, 50.3, and 72.0%, respectively) the muscle contraction amplitude; this is explained by its competitive action on the potential-controlled Ca2(+)-channels of the L-type (Ca 1.2). In parallel experiments on isolated rat heart mitochondria (RHM) it was shown that Cd2+ at concentrations of 15 and 25 microM produces swelling of non-energized and energized mitochondria in isotonic (with KNO2 and NH4NO3) and hypoosmotic (with 25 mM CH3COOK) media. Study of oxidative processes in RHM by polarographic method has shown 20 microM Cd2+ to disturb activity of respiratory mitochondrial chain. The rate of endogenous respiration of isolated mitochondria in the medium with Cd2+ in the presence of malate and succinate was approximately 5 times lower than in control. In experimental preparations, addition into the medium of DNP-uncoupler of oxidation and phosphorylation did not cause an increase of the oxygen consumption rate. Thus, the obtained data indicate that a decrease in the cardiac muscle contractility caused by Cd2+ is due not only to its direct blocking action on Ca2(+)-channels, but also is mediated by toxic effect on rat heart mitochondria, which was manifested as an increase in ion permeability of the inner mitochondrial membrane (IMM), acceleration of the energy-dependent K+ transport into the matrix of mitochondria, and inhibition of their respiratory chain. 相似文献
59.
I. V. Shemarova V. P. Nesterov S. M. Korotkov K. V. Sobol’ 《Journal of Evolutionary Biochemistry and Physiology》2017,53(5):368-379
The review addresses the role of Ca2+ ions in the development of ischemic disorders of myocardial contractility associated with changes in Ca2+ homeostasis in cardiomyocytes and mitochondrial Ca2+ overload. A special attention is paid to the analysis of intracellular signaling mechanisms activated during the development of ischemic and reperfusion injury of the myocardium. 相似文献
60.
I. V. Shemarova V. P. Nesterov 《Journal of Evolutionary Biochemistry and Physiology》2013,49(1):10-24
The review describes peculiarities of Ca2+-signalization in electro-excitable cells of higher eukaryotes. The light has been shed on problems of Ca2+-dependent mechanisms of regulation of muscle contractility and of neuronal synaptic plasticity in the higher vertebrate animals. A particular attention has been paid to analysis of contribution of such poorly studied components of Ca2+-signalization as non-selective TRPC-channels, Orai channels, sensory STIM1 proteins, Ca2+-controlled K+-channels of large and small conductance, and neuronal Ca2+-sensors (NCS). 相似文献