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741.
EDC3 phosphorylation regulates growth and invasion through controlling P‐body formation and dynamics
Jeremiah J Bearss Sathish KR Padi Neha Singh Marina CardoVila Jin H Song Ghassan Mouneimne Nikita Fernandes Yang Li Matthew R Harter Jaime MC Gard Anne E Cress Wolfgang Peti Andrew DL Nelson J Ross Buchan Andrew S Kraft Koichi Okumura 《EMBO reports》2021,22(4)
Regulation of mRNA stability and translation plays a critical role in determining protein abundance within cells. Processing bodies (P‐bodies) are critical regulators of these processes. Here, we report that the Pim1 and 3 protein kinases bind to the P‐body protein enhancer of mRNA decapping 3 (EDC3) and phosphorylate EDC3 on serine (S)161, thereby modifying P‐body assembly. EDC3 phosphorylation is highly elevated in many tumor types, is reduced upon treatment of cells with kinase inhibitors, and blocks the localization of EDC3 to P‐bodies. Prostate cancer cells harboring an EDC3 S161A mutation show markedly decreased growth, migration, and invasion in tissue culture and in xenograft models. Consistent with these phenotypic changes, the expression of integrin β1 and α6 mRNA and protein is reduced in these mutated cells. These results demonstrate that EDC3 phosphorylation regulates multiple cancer‐relevant functions and suggest that modulation of P‐body activity may represent a new paradigm for cancer treatment. 相似文献
742.
R. Holbrook J.M. Anderson A.C. Baird-Parker L.M. Dodds D. Sawhney S.H. Stuchbury D. Swaine 《Letters in applied microbiology》1989,8(4):139-142
A new method for detecting salmonellas in foods within 42 h is described. This highly specific and sensitive selective motility procedure gave an efficiency of 96.8% when tested against traditional methods using more than 800 food samples. It is stable at ambient temperatures and can be prepared for use in 5 min. 相似文献
743.
Cluster Computing - This article introduces a multi-class hierarchical algorithm for semi-supervised classification. The proposed algorithm incorporates the benefits of tree-based classification... 相似文献
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746.
Soil organic carbon (SOC) sequestration is a promising climate change mitigation option. In this context, the formation of the relatively long-lived mineral-associated organic carbon (MAOC) is key. To date, soils are considered to be limited in their ability to accumulate MAOC, mainly by the amount of clay and silt particles present. Using the comprehensive German Agricultural Soil Inventory, we selected 189 samples with a wide range of SOC (5–118 g kg−1) and clay contents (30–770 g kg−1) to test whether there is a detectable upper limit of MAOC content. We found that the proportion of MAOC was surprisingly stable for soils under cropland and grassland use across the whole range of bulk SOC contents. Soil texture influenced the slope of the relationship between bulk SOC and MAOC, but no upper limit was observed in any texture class. Also, C content in the fine fraction (g C kg−1 fraction) was negatively correlated to fine fraction content (g kg−1 bulk soil). Both findings challenge the notion that MAOC accumulation is limited by soil fine fraction content per se. 相似文献
747.
Soleja Neha Jairajpuri Mohamad Aman Queen Aarfa Mohsin Mohd. 《Journal of industrial microbiology & biotechnology》2019,46(12):1669-1683
Journal of Industrial Microbiology & Biotechnology - Due to the potential toxicity of mercury, there is an immediate need to understand its uptake, transport and flux within living cells.... 相似文献
748.
During microsporogenesis and pollen maturation, the tapetumin anthers of tomato (Lycopersicon esculentum) underwent severalultrastructural changes and ultimately degenerated. The changesobserved related to the secretory function of the tapetum andto the transfer of materials from the cytoplasm to the surfaceof tapetal cells. Electron dense deposits, initially in thevacuoles, disappeared coincident with the appearance of orbiculeson the cell wall. The fibrillar wall of the tapetal cells loosened,presumably to facilitate transfer of materials through the wall.In Addition, membranous fragments were a consistent featurein the tapetum wall and may play a role in transport of materials.The cells of the inner tapetum (towards the connective) andouter tapetum (towards the epidermis) had different ultrastructuralfeatures. The cytoplasm of the outer tapetum was more electrondense and had a higher proportion of dictyosomes and mitochondriathan the inner tapetum, indicating the greater secretory natureof the outer tapetum. The plastids and mitochondria also differedin morphology between the two regions. Degenerations of thetapetal cytoplasm began by the vacuolate microspore stage. Atanthesis, cytoplasm was absent but the orbicular wall of thetapetum remained appressed to the wall of the middle layer ofthe anther.Copyright 1993, 1999 Academic Press Lycopersicon esculentum, microsporogenesis, pollen development, tapetum development, tomato, ultrastructure 相似文献
749.
Summary Floral buds were initiated in Impatiens balsamina plants treated with 2,3,5-triiodobenzoic acid (TIBA) and kept under non-inductive 16- and 24-hr photoperiods, although much later than under inductive 8-hr photoperiods. TIBA did not affect extension growth to any appreciable extent but decreased the number of nodes on the main shoot under 8-hr and increased it under 16- and 24-hr photoperiods. Its effect on the development of lateral buds varied with photoperiod. TIBA-induced flowering resembles gibberellin-induced one, but its mechanism is not clear. 相似文献
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