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91.
Aditya Kumar Sharma Neha Dhasmana Neha Dubey Nishant Kumar Aakriti Gangwal Meetu Gupta Yogendra Singh 《Indian journal of microbiology》2017,57(1):1-10
Virulence is described as an ability of an organism to infect the host and cause a disease. Virulence factors are the molecules that assist the bacterium colonize the host at the cellular level. These factors are either secretory, membrane associated or cytosolic in nature. The cytosolic factors facilitate the bacterium to undergo quick adaptive—metabolic, physiological and morphological shifts. The membrane associated virulence factors aid the bacterium in adhesion and evasion of the host cell. The secretory factors are important components of bacterial armoury which help the bacterium wade through the innate and adaptive immune response mounted within the host. In extracellular pathogens, the secretory virulence factors act synergistically to kill the host cells. In this review, we revisit the role of some of the secreted virulence factors of two human pathogens: Mycobacterium tuberculosis—an intracellular pathogen and Bacillus anthracis—an extracellular pathogen. The advances in research on the role of secretory factors of these pathogens during infection are discussed. 相似文献
92.
Neha Handa Sukhmeen Kaur Kohli Ashwani Kumar Thukral Saroj Arora Renu Bhardwaj 《Acta Physiologiae Plantarum》2017,39(2):51
Chromium (Cr) is considered to be one of the major environmental hazards and poses a threat to both plant and animal health. Selenium (Se), however, has been recognized as an essential micronutrient in plants. To understand the role of Se(VI) in oxidative stress management and regulation of antioxidative defence mechanism against heavy metal stress, the seedlings of Brassica juncea L. were raised in Petri plates containing nutrient media supplemented with only with Se(VI) and Cr(VI), or their combination. It was observed that of Cr(VI) causes an increase in reactive oxygen species (ROS) in the seedlings leading to oxidative stress. Histological studies using confocal and visible microscopy confirmed the biochemical results. Supplementation of up to 4 µM of Se(VI) to media containing 300 µM of Cr(VI) reduced the contents of ROS and increased enzymatic and non-enzymatic antioxidants in the seedlings. At a concentration of 6 µM, however, Se(VI) was toxic. The results suggested that at appropriate concentrations, the exogenous application of Se(VI) enabled the B. juncea seedlings to counteract the effects of Cr(VI), thereby increasing the resistance of plants. 相似文献
93.
Pradnya P. Kanekar Snehal O. Kulkarni Prashant K. Dhakephalkar Kantimati G. Kulkarni Neha Saxena 《Geomicrobiology journal》2017,34(3):242-248
Haloarchaea live in saline environments and require salt for their growth. The present study reports on the isolation of a haloarchaeal strain RG3D.1 identified as Haloferax larsenii using Sehgal and Gibbons medium with 3.42 M NaCl, from Rock Garden at Malvan in the West Coast of India. The rock type of Malvan Coast is correlated based on geological setting with the basal member of the Bababudan group placed at 2728 ± 102 million years ago (Ma). The haloarchaeal strain produced bacteriorhodopsin (BR) (0.137 g l?1) and generated electric potential of 49.2 mV when exposed to sunlight. Thus, this is the first report on the isolation of a haloarchaeon, Haloferax larsenii, from red rocky substrate and production of BR. 相似文献
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95.
Tang Ming Li Tong Gandhi Neha S. Burrage Kevin Gu YuanTong 《Biomechanics and modeling in mechanobiology》2017,16(3):1023-1033
Biomechanics and Modeling in Mechanobiology - Collagen is an abundant structural biopolymer in mammal vertebrates, providing structural support as well as mechanical integrity for connective... 相似文献
96.
Circulating Adiponectin Levels Differ Between Patients with Multiple Myeloma and its Precursor Disease 下载免费PDF全文
97.
Kumar Srivastava B Soni R Patel JZ Jha S Shedage SA Gandhi N Sairam KV Pawar V Sadhwani N Mitra P Jain MR Patel PR 《Bioorganic & medicinal chemistry letters》2008,18(14):3882-3886
Facile synthesis of biaryl pyrazole sulfonamide derivative of 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid piperidin-1-ylamide (SR141716, 1) and an investigation of the effect of replacement of the –CO group in the compound 1 by the –SO2 group in the aminopiperidine region is reported. Primary ex-vivo pharmacological testing and in vitro screening of sulfonamide derivative 2 showed the loss of CB1 receptor antagonism. 相似文献
98.
Fermented culture of Streptomyces fulvissimus was found to secrete an antibacterial protein inhibitory to Micrococcus luteus, Bacillus subtilis, Bacillus cereus and methicillin resistant Staphylococcus aureus (MRSA) strains. The extracellular protein from the fermented culture on concentration revealed a high molecular weight peptide of 63kDa on SDS-PAGE gel and the region on gel displayed inhibitory activity against methicillin resistant Staphylococcus aureus. Bioactivity of the extra cellular protein was non-sensitive to proteinase K, alpha chymotrypsin, protease, EDTA (ethylene diamine tetra acetic acid), PMSF (phenyl methyl sulfonyl fluoride) and DMSO (dimethyl sulfoxide) but partially susceptible to amylase and heat. Glycoprotein nature of the proteinaceous compound was confirmed by periodic acid schiffs (PAS) staining. The secretary protein of S. fulvissimus demonstrated a significant activity against MRSA strain. It could be an important source for developing new drugs to control multidrug resistant gram positive bacteria. 相似文献
99.
Hydrogenotrophic denitrification was demonstrated using hydrogen generated from anoxic corrosion of metallic iron. For this purpose, a mixture of hydrogenated water and nitrate solution was used as reactor feed. A semi-batch reactor with nitrate loading of 2000 mg m−3 d−1 and hydraulic retention time (HRT) of 50 days produced effluent with nitrate concentration of 0.27 mg N L−1 (99% nitrate removal). A continuous flow reactor with nitrate loading of 28.9 mg m−3 d−1 and HRT of 15.6 days produced effluent with nitrate concentration of ∼0.025 mg N L−1 (95% nitrate removal). In both cases, the concentration of nitrate degradation by-products, viz., ammonia and nitrite, were below detection limits. The rate of denitrification in the reactors was controlled by hydrogen availability, and hence to operate such reactors at higher nitrate loading rates and/or lower HRT than reported in the present study, hydrogen concentration in the hydrogenated water must be significantly increased. 相似文献
100.
Bacteriocin: safest approach to preserve food products 总被引:1,自引:0,他引:1
Start of the 21st century with its universal call to feed the hungry is an appropriate time to refocus attention on food security
and especially the impact of biopatenting on poor communities who are the primary victims of hunger in our world. Antibacterial
metabolites of lactic acid bacteria and Bacillus spp have potential as natural preservatives to control the growth of spoilage and pathogenic bacteria in food. Among them,
bacteriocin is used as a preservative in food due to its heat stability, wider pH tolerance and its proteolytic activity.
Due to thermo stability and pH tolerance it can withstand heat and acidity/alkanity of food during storage condition. Bacteriocin
are ribosomally synthesized peptides originally defined as proteinaceous compound affecting growth or viability of closely
related organisms. Research is going on extensively to explore the nascent field of biopreservation. Scientists all over the
world are showing their keen interest to isolate different types of bacteriocin producing strains and characterize bacteriocin
produced by them for food preservation. 相似文献