排序方式: 共有607条查询结果,搜索用时 640 毫秒
171.
The present study was aimed to explore the potential of an antidepressant drug lithium (Li) in reducing aluminium (Al) induced
neurotoxicity. To carry out the investigations, Al was administered orally (100 mg AlCl3/Kg b wt/day) whereas, Li was administered through diet (1.1 g Li2CO3/Kg diet, daily) for a total duration of 2 months. Al treatment resulted in a significant increase in the activity of enzyme
nitric oxide synthase and the levels of l-citrulline which, however, were decreased appreciably following lithium supplementation. Al treatment also revealed an increase
in DNA fragmentation as evidenced by an increase in number of comets. Interestingly, Li supplementation to Al treated rats
reduced the damage inflicted on DNA by Al. Ultrastructural studies revealed an increase in chromatin condensation with discontinuity
in nuclear membrane in both the cerebrum and cerebellum of Al treated rats which showed improvement following Li supplementation.
Alterations in the structure of synapse and mitochondrial swelling were also seen. The present study shows the potential of
Li in containing the damage inflicted by Al on rat brain. 相似文献
172.
173.
Neha Kumari Tripurari Kumar Harsh Arnab S. Bhattacharya Kumar Gaurav Ranjana Verma Sanjoy K. Samdarshi 《Luminescence》2023,38(7):1282-1286
Transition metal oxide has emerged as one of the most potential candidates for environment remediation by utilizing solar energy through photocatalysis. This study compares the optical characteristics of zinc oxide (ZnO) and ceria-doped zinc oxide (CeZnO) nanoparticles synthesized through a facile chemical precipitation method without using any assistant catalyst. The present work investigates the consequences of ceria (cerium dioxide, CeO2) intrusion on the photocatalytic activity of ZnO nanoparticles using methylene blue (MB) as a probe pollutant. The CeZnO showed an increase in photoactivity when compared to ZnO nanoparticles for degradation of MB in an aqueous solution under ultraviolet (UV) irradiance. The resulting heterojunction between ZnO and that of ceria enhances the charge separation efficiency showing a strong correlation between ZnO and CeO2 heterojunction on the charge transfer mechanism across the interface. 相似文献
174.
175.
Neha Manhas Parvesh Singh Chunderika Mocktar Moganavelli Singh Neil Koorbanally 《化学与生物多样性》2021,18(5):e2100096
A series of quinazolin-4-one Schiff bases were synthesized and tested in vitro for their cytotoxicity against two cancerous cell lines (MCF-7, Caco-2) and a human embryonic cell line (HEK-293) including their antibacterial evaluation against two Gram-positive and four Gram-negative bacterial strains. Most of the quinazoline-Schiff bases exhibited potent cytotoxicity against Caco-2. 3-[(Z)-({4-[(But-2-yn-1-yl)oxy]phenyl}methylidene)amino]-2-methylquinazolin-4(3H)-one ( 6f ) with the O-butyne functional group displayed three-fold higher cytotoxic activity (IC50=376.8 μM) as compared to 5-fluorouracil (5-FU; IC50=1086.1 μM). However, all compounds were found to be toxic to HEK-293, except for 3-[(Z)-({4-[(2,4-difluorophenyl)methoxy]phenyl}methylidene)amino]-2-methylquinazolin-4(3H)-one ( 6h ) that showed ∼three-fold lower toxicity and higher selectivity index than 5-FU. Structure–activity relationship (SAR) analysis revealed that O-alkylation generally increased the anticancer activity and selectivity of quinazoline-4-one Schiff bases toward Caco-2 cells. The fluorinated Schiff-base generally exhibited even more significant cytotoxic activity compared to their chlorine analogs. Surprisingly, none of the quinazoline-4-one Schiff bases displayed encouraging antibacterial activity against the bacterial strains investigated. Most of the compounds were predicted to show compliance with the Lipinski parameters and ADMET profiles, indicating their drug-like properties. 相似文献
176.
The present study was carried out to elucidate the effectiveness of curcumin in mitigating the adverse effects caused by N-Methyl N-Nitrosourea (MNU) on mouse cerebellum and cerebrum. Male laca mice received either intravenous MNU treatment at a dose of
10 mg/kg bw in sterile double distilled water, curcumin alone 60 mg/kg bw in drinking water, or combined MNU and curcumin
treatment on alternate days for a period of 2 months. The effects of different treatments were studied on carbohydrate metabolizing
enzymes viz: hexokinase, glucose-6-phosphatase (G6P), glucose-6-isomerase (G6I), lactate dehydrogenase (LDH), succinate dehydrogenase
(SDH) and glycogen levels. Curcumin supplementation to MNU treated mice was able to reduce significantly the activities of
the G6P, G6I, hexokinase, LDH, SDH and increased the glycogen contents in both the regions of brain which were altered following
MNU treatment. Hence, curcumin shall prove to be effective in ameliorating the adverse effects caused by MNU. 相似文献
177.
Perrine Marcenac W. Robert Shaw Evdoxia G. Kakani Sara N. Mitchell Adam South Kristine Werling Eryney Marrogi Daniel G. Abernathy Rakiswend Serge Yerbanga Roch K. Dabir Abdoulaye Diabat Thierry Lefvre Flaminia Catteruccia 《PLoS pathogens》2020,16(12)
Anopheles mosquitoes have transmitted Plasmodium parasites for millions of years, yet it remains unclear whether they suffer fitness costs to infection. Here we report that the fecundity of virgin and mated females of two important vectors—Anopheles gambiae and Anopheles stephensi—is not affected by infection with Plasmodium falciparum, demonstrating that these human malaria parasites do not inflict this reproductive cost on their natural mosquito hosts. Additionally, parasite development is not impacted by mating status. However, in field studies using different P. falciparum isolates in Anopheles coluzzii, we find that Mating-Induced Stimulator of Oogenesis (MISO), a female reproductive gene strongly induced after mating by the sexual transfer of the steroid hormone 20-hydroxyecdysone (20E), protects females from incurring fecundity costs to infection. MISO-silenced females produce fewer eggs as they become increasingly infected with P. falciparum, while parasite development is not impacted by this gene silencing. Interestingly, previous work had shown that sexual transfer of 20E has specifically evolved in Cellia species of the Anopheles genus, driving the co-adaptation of MISO. Our data therefore suggest that evolution of male-female sexual interactions may have promoted Anopheles tolerance to P. falciparum infection in the Cellia subgenus, which comprises the most important malaria vectors. 相似文献
178.
179.
Suelem D. Ramalho Rajgopal Sharma Jessica K. White Neha Aggarwal Anita Chalasani Mansoureh Sameni Kamiar Moin Paulo C. Vieira Claudia Turro Jeremy J. Kodanko Bonnie F. Sloane 《PloS one》2015,10(11)
The cysteine protease cathepsin B has been causally linked to progression and metastasis of breast cancers. We demonstrate inhibition by a dipeptidyl nitrile inhibitor (compound 1) of cathepsin B activity and also of pericellular degradation of dye-quenched collagen IV by living breast cancer cells. To image, localize and quantify collagen IV degradation in real-time we used 3D pathomimetic breast cancer models designed to mimic the in vivo microenvironment of breast cancers. We further report the synthesis and characterization of a caged version of compound 1, [Ru(bpy)2(1)2](BF4)2 (compound 2), which can be photoactivated with visible light. Upon light activation, compound 2, like compound 1, inhibited cathepsin B activity and pericellular collagen IV degradation by the 3D pathomimetic models of living breast cancer cells, without causing toxicity. We suggest that caged inhibitor 2 is a prototype for cathepsin B inhibitors that can control both the site and timing of inhibition in cancer. 相似文献
180.