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71.
Pourrahimi Maryam Panahi Negar Babapour Vahab Asghari Ahmad 《International journal of peptide research and therapeutics》2019,25(2):739-748
International Journal of Peptide Research and Therapeutics - Nowadays inquiry of possible interplay between different neurotransmitters in brain function is one of the major fields of interest for... 相似文献
72.
Abolghasempour Shokoofeh Zendehdel Morteza Panahi Negar Jahandideh Alireza Gilanpour Hasan 《International journal of peptide research and therapeutics》2019,25(3):835-843
International Journal of Peptide Research and Therapeutics - This study was designed to determine possible interaction of the central nociceptin/orphanin FQ (N/OFQ) and glutamatergic system on... 相似文献
73.
Negar Memarian Sarah K. Madsen Paul M. Macey Itzhak Fried Jerome Engel Jr. Paul M. Thompson Richard J. Staba 《PloS one》2015,10(4)
Hypersynchronous (HYP) and low voltage fast (LVF) activity are two separate ictal depth EEG onsets patterns often recorded in presurgical patients with MTLE. Evidence suggests the mechanisms generating HYP and LVF onset seizures are distinct, including differential involvement of hippocampal and extra-hippocampal sites. Yet the extent of extra-hippocampal structural alterations, which could support these two common seizures, is not known. In the current study, preoperative MRI from 24 patients with HYP or LVF onset seizures were analyzed to determine changes in cortical thickness and relate structural changes to spatiotemporal properties of the ictal EEG. Overall, onset and initial ipsilateral spread of HYP onset seizures involved mesial temporal structures, whereas LVF onset seizures involved mesial and lateral temporal as well as orbitofrontal cortex. MRI analysis found reduced cortical thickness correlated with longer duration of epilepsy. However, in patients with HYP onsets, the most affected areas were on the medial surface of each hemisphere, including parahippocampal regions and cingulate gyrus, whereas in patients with LVF onsets, the lateral surface of the anterior temporal lobe and orbitofrontal cortex showed the greatest effect. Most patients with HYP onset seizures were seizure-free after resective surgery, while a higher proportion of patients with LVF onset seizures had only worthwhile improvement. Our findings confirm the view that recurrent seizures cause progressive changes in cortical thickness, and provide information concerning the structural basis of two different epileptogenic networks responsible for MTLE. One, identified by HYP ictal onsets, chiefly involves hippocampus and is associated with excellent outcome after standardized anteromedial temporal resection, while the other also involves lateral temporal and orbitofrontal cortex and a seizure-free surgical outcome occurs less after this procedure. These results suggest that a more extensive tailored resection may be required for patients with the second type of MTLE. 相似文献
74.
The pharmacokinetics of the antimalarial drug (+/-)-halofantrine are stereoselective in humans and rats. To better understand the stereoselective metabolism of the drug to its primary metabolite, desbutylhalofantrine (DHF), a series of in vitro and in vivo experiments were undertaken in the rat. Formation of (-)-DHF exceeded that of (+)-DHF in liver microsomes [(-):(+) ratio of intrinsic formation clearances = 1.4]. In contrast, in intestinal microsomes no significant stereoselectivity was noted in the formation of the DHF enantiomers. Intestinal microsomes were also less efficient at producing the DHF enantiomers than were liver microsomes. Based on kinetic analysis of the DHF formation, there appeared to be more than one enzyme involved in the biotransformation. (+/-)-Ketoconazole (KTZ) effectively inhibited the formation of both DHF enantiomers by both liver and intestinal microsomes, although the reduction was more marked in liver microsomes. Through a combination of the use of CYP antibodies and recombinant CYP isoenzymes, the involvement of CYP 2B1/2, 3A1, 3A2, 1A1, 2C11, 2C6, 2D1, and 2D2 were implicated in the metabolism of halofantrine to DHF. Of these, CYP3A1/2 and CYP2C11 appeared to be the primary isoenzymes involved, although CYP2C11 showed greater (+)-DHF than (-)-DHF formation, whereas for CYP3A1 it was similar to the isolated rat liver microsomes. In vivo, oral (+/-)-KTZ caused significant increases in plasma halofantrine and decreases in DHF enantiomer plasma concentrations. 相似文献
75.
Katherine S Elliott Marc Haber Hinda Daggag George B Busby Rizwan Sarwar Derek Kennet Michael Petraglia Lawrence J Petherbridge Parisa Yavari Frauke U Heard-Bey Bindu Shobi Tariq Ghulam Dalia Haj Alia Al Tikriti Alshafi Mohammad Suma Antony Maitha Alyileili Shatha Alaydaroos Evelyn Lau Mark Butler Arash Yavari Julian C Knight Houman Ashrafian Maha T Barakat 《Molecular biology and evolution》2022,39(3)
The indigenous population of the United Arab Emirates (UAE) has a unique demographic and cultural history. Its tradition of endogamy and consanguinity is expected to produce genetic homogeneity and partitioning of gene pools while population movements and intercontinental trade are likely to have contributed to genetic diversity. Emiratis and neighboring populations of the Middle East have been underrepresented in the population genetics literature with few studies covering the broader genetic history of the Arabian Peninsula. Here, we genotyped 1,198 individuals from the seven Emirates using 1.7 million markers and by employing haplotype-based algorithms and admixture analyses, we reveal the fine-scale genetic structure of the Emirati population. Shared ancestry and gene flow with neighboring populations display their unique geographic position while increased intra- versus inter-Emirati kinship and sharing of uniparental haplogroups, reflect the endogamous and consanguineous cultural traditions of the Emirates and their tribes. 相似文献
76.
Zeenat Farooq Fedho Kusuma Phillip Burke Catherine R. Dufour Duckgue Lee Negar Tabatabaei Phoenix Toboz Ernest Radovani Jack F. Greenblatt Jalees Rehman Jacob Class Arkady Khoutorsky Bruno D. Fonseca Justin M. Richner Eloi Mercier Guillaume Bourque Vincent Gigure Arvind R. Subramaniam Jaeseok Han Soroush Tahmasebi 《The Journal of biological chemistry》2022,298(9)
77.
Roland Pfoh Adithya S. Subramanian Jingjing Huang Dustin J. Little Adam Forman Benjamin R. DiFrancesco Negar Balouchestani-Asli Elena N. Kitova John S. Klassen Rgis Poms Mark Nitz P. Lynne Howell 《PLoS pathogens》2022,18(8)
The synthesis of exopolysaccharides as biofilm matrix components by pathogens is a crucial factor for chronic infections and antibiotic resistance. Many periplasmic proteins involved in polymer processing and secretion in Gram-negative synthase dependent exopolysaccharide biosynthetic systems have been individually characterized. The operons responsible for the production of PNAG, alginate, cellulose and the Pel polysaccharide each contain a gene that encodes an outer membrane associated tetratricopeptide repeat (TPR) domain containing protein. While the TPR domain has been shown to bind other periplasmic proteins, the functional consequences of these interactions for the polymer remain poorly understood. Herein, we show that the C-terminal TPR region of PgaA interacts with the de-N-acetylase domain of PgaB, and increases its deacetylase activity. Additionally, we found that when the two proteins form a complex, the glycoside hydrolase activity of PgaB is also increased. To better understand structure-function relationships we determined the crystal structure of a stable TPR module, which has a conserved groove formed by three repeat motifs. Tryptophan quenching, mass spectrometry analysis and molecular dynamics simulation studies suggest that the crystallized TPR module can bind PNAG/dPNAG via its electronegative groove on the concave surface, and potentially guide the polymer through the periplasm towards the porin for export. Our results suggest a scaffolding role for the TPR domain that combines PNAG/dPNAG translocation with the modulation of its chemical structure by PgaB. 相似文献
78.
A simple and reliable method that could be used in developing countries to pasteurize milk and water with solar energy is described. A cardboard reflector directs sunshine onto a black jar, heating water to pasteurizing temperatures in several hours. A reusable water pasteurization indicator verifies that pasteurization temperatures have been reached. 相似文献
79.
Background
Recently, a novel single-switch access technology based on infrared thermography was proposed. The technology exploits the temperature differences between the inside and surrounding areas of the mouth as a switch trigger, thereby allowing voluntary switch activation upon mouth opening. However, for this technology to be clinically viable, it must be validated against a gold standard switch, such as a chin switch, that taps into the same voluntary motion. 相似文献80.
Aghdaie MH Azarpira N Kazemi K Geramizadeh B Darai M Malekhoseini SA 《Molecular biology reports》2011,38(5):3593-3597
The 14-bp polymorphism in exon 8 of the HLA-G gene is associated with HLA-G mRNA stability and the patterns of alternative
isoform splicing and may influence the functionality of the HLA-G molecule. HLA-G expression was related to allograft acceptance
and fewer episodes of acute rejection during heart, kidney and liver–kidney transplantation. In order to determine a possible
correlation between the 14-bp insertion/deletion polymorphism and kidney allograft outcome in our population, genomic DNA
was isolated from 144 patients who had received isolated kidney allografts. The recipients was divided into two groups, grafts
presenting features of rejection group and a non-rejection group, and compared them with a control group of 100 healthy subjects.
There was no significant difference in allelic frequencies of 14-bp insertion/deletion polymorphism between normal controls
and kidney transplant patients. No significant difference was found between the RG and the NRG regarding the 14-bp genotypes
and alleles. Therefore, additional studies with more sample size from other populations with analysis of other HLA-G polymorphisms
are necessary to define this polymorphism as a valuable clinical marker. 相似文献