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排序方式: 共有1444条查询结果,搜索用时 61 毫秒
61.
Tanya Biswas Alok Kalra A. K. Mathur R. K. Lal Manju Singh Archana Mathur 《Applied microbiology and biotechnology》2016,100(11):4909-4922
62.
Trivedi Jayati Singh Jasvinder Atray Neeraj Ray S. S. Agrawal Deepti 《Bioprocess and biosystems engineering》2019,42(12):2047-2054
Bioprocess and Biosystems Engineering - In the present study, the effect of irradiance on growth performance of Scenedesmus obliquus was investigated, and various non-linear growth models were... 相似文献
63.
64.
Lal B 《Journal of molecular modeling》2007,13(4):531-536
The mechanism of the enantioselective binding of L-histidine with C60 fullerene and its derivatives, (1,2-methanofullerene C60)-61-carboxylic acid, diethyl (1,2-methanofullerene C60)-61-61-dicarboxylate and tert-butyl (1,2-methanofullerene C60)-61-carboxylate based chiral selectors was studied by quantum chemical calculations. All the molecules were fully optimized at RHF/6-31G* basis set. Relative energies between the different complexes were subsequently estimated with single-point electronic energies computed using Møller-Plesset perturbation theory (MP2). Stability and feasibility of all the generated structures were supported by their respective energy minima and fundamental frequencies. It was observed that interaction of fullerene derivatives with L-histidine is due to the existence of hydrogen bonding forces during the complex formation. The intermolecular forces, flow of atomic charges, binding energy, hardness, dipole moment and localization of electrostatic potential are in agreement with enantioselective interaction of L-histidine with C60 fullerene and its derivatives. It is found that theoretical evaluation to be consistent with the experimental data. 相似文献
65.
Guillaume Fouché Thomas Michel Anaïs Lalève Nick X. Wang David H. Young Brigitte Meunier Danièle Debieu Sabine Fillinger Anne-Sophie Walker 《Environmental microbiology》2022,24(3):1117-1132
Acquired resistance is a threat to antifungal efficacy in medicine and agriculture. The diversity of possible resistance mechanisms and highly adaptive traits of pathogens make it difficult to predict evolutionary outcomes of treatments. We used directed evolution as an approach to assess the resistance risk to the new fungicide fenpicoxamid in the wheat pathogenic fungus Zymoseptoria tritici. Fenpicoxamid inhibits complex III of the respiratory chain at the ubiquinone reduction site (Qi site) of the mitochondrially encoded cytochrome b, a different site than the widely used strobilurins which inhibit the same complex at the ubiquinol oxidation site (Qo site). We identified the G37V change within the cytochrome b Qi site as the most likely resistance mechanism to be selected in Z. tritici. This change triggered high fenpicoxamid resistance and halved the enzymatic activity of cytochrome b, despite no significant penalty for in vitro growth. We identified negative cross-resistance between isolates harbouring G37V or G143A, a Qo site change previously selected by strobilurins. Double mutants were less resistant to both QiIs and quinone outside inhibitors compared to single mutants. This work is a proof of concept that experimental evolution can be used to predict adaptation to fungicides and provides new perspectives for the management of QiIs. 相似文献
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67.
Jayakumar T. T. K. Shakhovskoy I. B. Prasoon N. P. K. Kathirvelpandian A. Ajith Kumar T. T. Lal K. K. 《Journal of Ichthyology》2019,59(5):697-706
Journal of Ichthyology - The present study reports the first record of the rearfin flying fish, Cypselurus opisthopus (Bleeker, 1865), in the south-eastern Arabian Sea based on a single specimen... 相似文献
68.
Neeraj Kumar Aditi Singh Sonam Grover Anchala Kumari Pawan Kumar Dhar Ramesh Chandra 《Journal of biomolecular structure & dynamics》2019,37(8):2098-2109
Outbreak of Human Herpes virus-5 (HHV-5) infection in emerging countries has raised worldwide health concern owing to prevalence of congenital impairments and life threatening consequences in immunocompromised individuals. Thus, there lies an impending need to develop vaccine against HHV-5. HHV-5 enters into host cells with the help of necessary components glycoprotein B (gB) and H/L. In this study, the conformational linear B-cell and T-cell epitopes for gB of HHV-5 have been predicted using conformational approaches, for their possible collective use as vaccine candidates. We examined epitope’s interactions with major histocompatibility complexes using molecular docking and also investigated their stable binding with specific toll like receptor-2 (TLR2), present on host cells during HHV-5 infection. Predicted MHC-I epitope ‘LVAIAVVII’ with high antigenicity and large coverage of HLA alleles was found to superimpose on MHC-II epitope (Rank 1) and was also identified to be the core sequence of putative B cell epitope ‘ILVAIAVVIITYLI’. Resulting epitope was found to have consistent interaction with TLR2 during long term (100?ns) MD run. We also validated this nonamer epitope for its dissimilarity with human genome and high population coverage, suggesting it to be a potential vaccine candidate with higher coverage for both the MHC alleles of Indian population.
Communicated by Ramaswamy H. Sarma 相似文献
69.
McAndrews Ryan S. Eich Andreas Ford Amanda K. Bejarano Sonia Lal Ronal R. Ferse Sebastian C. A. 《Coral reefs (Online)》2019,38(3):431-441
Coral Reefs - Epilithic algae are a ubiquitous component of coral reefs. Components of the epilithic algal matrix (EAM) can have a significant influence on coral settlement and benthic feeding by... 相似文献
70.
Amy Li K. Campbell S. Lal Y. Ge A. Keogh P. S. Macdonald P. Lau John Lai W. A. Linke J. Van der Velden A. Field B. Martinac M. Grosser Cristobal dos Remedios 《Biophysical reviews》2022,14(1):369
In this review, we present our current understanding of peripartum cardiomyopathy (PPCM) based on reports of the incidence, diagnosis and current treatment options. We summarise opinions on whether PPCM is triggered by vascular and/or hormonal causes and examine the influence of comorbidities such as preeclampsia. Two articles published in 2021 strongly support the hypothesis that PPCM may be a familial disease. Using large cohorts of PPCM patients, they summarised the available genomic DNA sequence data that are expressed in human cardiomyocytes. While PPCM is considered a disease predominately affecting the left ventricle, there are data to suggest that some cases also involve right ventricular failure. Finally, we conclude that there is sufficient evidence to warrant an RNAseq investigation and that this would be most informative if performed at the cardiomyocytes level rather than analysing genomic DNA from the peripheral circulation. Given the rarity of PPCM, the combined resources of international human heart tissue biobanks have assembled 30 ventricular tissue samples from PPCM patients, and we are actively seeking to enlarge this patient base by collaborating with human heart tissue banks and research laboratories who would like to join this endeavour. 相似文献