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排序方式: 共有338条查询结果,搜索用时 7 毫秒
331.
332.
Neda Mohammadi Mina Hemmati Behrouz Motlagh Arezou Biyabani 《Cell biochemistry and function》2024,42(2):e3973
The structural and functional disorders of the testis and ovary are one of the main complications of hyperglycemia. Betaine is a trimethyl glycine with antioxidant, antidiabetic, and anti-inflammatory potential. The aim of this study is to investigate the potential of betaine on the expression of aging and oxidative stress markers in ovarian and testicular cells under hyperglycemic conditions. Testicular and ovarian cells were subjected to four different conditions, including normal glucose and hyperglycemia, with or without betaine (5 mM). The cells with hyperglycemia saw an increase in malondialdehyde (MDA), methylglyoxal (MGO), expression of a receptor for AGE, and aging-related genes (β-GAL), and a decrease in the activity of antioxidant enzymes including catalase, glutathione peroxidase, and superoxide dismutase. The treatment with betaine, in contrast, decreased the amount of MGO and MDA, and also downregulated aging-related signaling. Although hyperglycemia induces senescence in testicular and ovarian cells, the use of betaine may have a protective effect against the cell senescence, which may be useful in the management of infertility. 相似文献
333.
Alia Noorani Zaid Sadiq Neda Minakaran Catherine Coleman Val A Thomas Kefah Mokbel 《International Seminars in Surgical Oncology : ISSO》2008,5(1):8
Paraneoplastic cerebellar degeneration is part of a rare spectrum of neurological syndromes whereby gynaecological, lung or breast cancers present primarily with neurological manifestations. The presence of onconeural antibodies and PET scanning help in the challenging diagnosis of these conditions but despite the treatment of the primary cancer, the prognosis for the neurological symptoms is poor. 相似文献
334.
Iulian Emil Tampu Anders Eklund Kenth Johansson Oliver Gimm Neda Haj-Hosseini 《Journal of biophotonics》2023,16(2):e202200227
Intraoperative guidance tools for thyroid surgery based on optical coherence tomography (OCT) could aid distinguish between normal and diseased tissue. However, OCT images are difficult to interpret, thus, real-time automatic analysis could support the clinical decision-making. In this study, several deep learning models were investigated for thyroid disease classification on 2D and 3D OCT data obtained from ex vivo specimens of 22 patients undergoing surgery and diagnosed with several thyroid pathologies. Additionally, two open-access datasets were used to evaluate the custom models. On the thyroid dataset, the best performance was achieved by the 3D vision transformer model with a Matthew's correlation coefficient (MCC) of 0.79 (accuracy = 0.90) for the normal-versus-abnormal classification. On the open-access datasets, the custom models achieved the best performance (MCC > 0.88, accuracy > 0.96). Results obtained for the normal-versus-abnormal classification suggest OCT, complemented with deep learning-based analysis, as a tool for real-time automatic diseased tissue identification in thyroid surgery. 相似文献
335.
Screening fungi for the production of an inhibitor of HMG CoA reductase: Production of mevinolin by the fungi of the genus Pleurotus 总被引:1,自引:0,他引:1
Nina Gunde-Cimerman Joica Friedrich Aleksa Cimerman Neda Beniki 《FEMS microbiology letters》1993,111(2-3):203-206
Abstract Two thermophilic archaea belonging to the genus Sulfolobus , grown on glucose, produced an extracellular polysaccharide (EPS). The production of EPS conducted both in 90 1 fermentor and in batch culture reached the maximum during the stationary phase of growth. The chemical analysis (FT-IR, HPAE-PAD, UV, Optical Rotation) of the biopolymer and of its acid hydrolizate suggested glucose, mannose, glucosamine and galactose as major components of the sulfated heteropolysaccharide. 相似文献
336.
Multi-spectroscopic and molecular docking studies on the interaction of neotame with calf thymus DNA
Fahimeh Kheirdoosh Mahsa Pazhavand Mahya Sariaslani Neda Hosseinpour Moghadam Sadegh Salehzadeh 《Nucleosides, nucleotides & nucleic acids》2020,39(5):699-714
AbstractIn this paper, we have studied the in vitro binding of neotame (NTM), an artificial sweetener, with native calf thymus DNA using different methods including spectrophotometric, spectrofluorometric, competition experiment, circular dichroism (CD), and viscosimetric techniques. From the spectrophotometric studies, the binding constant (Kb) of NTM-DNA was calculated to be 2?×?103 M?1. The quenching of the intrinsic fluorescence of NTM in the presence of DNA at different temperatures was also used to calculate binding constants (Kb) as well as corresponding number of binding sites (n). Moreover, the obtained results indicated that the quenching mechanism involves static quenching. By comparing the competitive fluorimetric studies with Hoechst 33258, as a known groove probe, and methylene blue, as a known intercalation probe, and iodide quenching experiments it was revealed that NTM strongly binds in the grooves of the DNA helix, which was further confirmed by CD and viscosimetric studies. In addition, a molecular docking method was employed to further investigate the binding interactions between NTM and DNA, and confirm the obtained results. 相似文献
337.
Matthew D. Ettleson Ava Raine Alice Batistuzzo Samuel P. Batista Elizabeth McAninch Maria Cristina T.V. Teixeira Jacqueline Jonklaas Neda Laiteerapong Miriam O. Ribeiro Antonio C. Bianco 《Endocrine practice》2022,28(3):257-264
ObjectivePatient-centered studies have shown that several patients on thyroid hormone replacement therapy for hypothyroidism exhibit persistent symptoms, including “brain fog.” Here, we aimed to determine which of these specific symptoms are associated with brain fog, identify patient-reported factors that modify these symptoms, and identify patient concerns related to brain fog not included in thyroid-specific questionnaires.MethodsA survey on brain fog symptoms adapted from thyroid-specific patient-reported outcome was distributed online. Textual data analysis was performed to identify common areas of concern from open-ended survey responses.ResultsA total of 5170 participants reporting brain fog while being treated for hypothyroidism were included in the analysis. Of these, 2409 (46.6%) participants reported symptom onset prior to the diagnosis of hypothyroidism, and 4096 (79.2%) participants experienced brain fog symptoms frequently. Of the symptoms listed, participants associated fatigue and forgetfulness most frequently with brain fog. More rest was the most common factor provided for improving symptoms. The textual data analysis identified areas of concern that are not often included in thyroid-specific quality of life questionnaires, including a focus on the diagnosis of hypothyroidism, the types and doses of medications, and the patient-doctor relationship.ConclusionBrain fog in patients treated for hypothyroidism was associated most frequently with fatigue and cognitive symptoms. Several additional areas of patient concern were found to be associated with brain fog, which are not typically addressed in thyroid-specific questionnaires. 相似文献