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Rayyan Manwar Xin Li Sadreddin Mahmoodkalayeh Eishi Asano Dongxiao Zhu Kamran Avanaki 《Journal of biophotonics》2020,13(10)
One of the key limitations for the clinical translation of photoacoustic imaging is penetration depth that is linked to the tissue maximum permissible exposures (MPE) recommended by the American National Standards Institute (ANSI). Here, we propose a method based on deep learning to virtually increase the MPE in order to enhance the signal‐to‐noise ratio of deep structures in the brain tissue. The proposed method is evaluated in an in vivo sheep brain imaging experiment. We believe this method can facilitate clinical translation of photoacoustic technique in brain imaging, especially in transfontanelle brain imaging in neonates. 相似文献
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Anthony R. Gangloff Jason Brown Ron de Jong Douglas R. Dougan Charles E. Grimshaw Mark Hixon Andy Jennings Ruhi Kamran Andre Kiryanov Shawn O’Connell Ewan Taylor Phong Vu 《Bioorganic & medicinal chemistry letters》2013,23(16):4501-4505
Structure based drug design of a series of novel 1,4-benzoxazin-3-one derived PARP-1 inhibitors are described. The synthesis, enzymatic & cellular activities and pharmacodynamic effects are described. Optimized analogs demonstrated inhibition of poly-ADP-ribosylation in SW620 tumor bearing nude mice through 24 h following a single dose. 相似文献
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Houshang Nemati Reza Khodarahmi Ameneh Rahmani Ali Ebrahimi Mojtaba Amani Kamran Eftekhari 《Cell biochemistry and function》2013,31(1):36-40
Psoriasis is a chronic inflammatory skin disease characterized by excessive cellular replication. Apolipoproteins are genetically determined molecule whose role has been implied in cardiovascular pathology. Vascular adhesion protein?1 (VAP?1) is an adhesion molecule with an enzymatic activity that partakes in the migration process of lymphocytes into sites of inflammation. Our purpose was to evaluate the plasma lipid profiles, apolipoproteins (A1, B) and Lp (a) and VAP?1 in order to compare the lipid profile in psoriatic patients with non‐affected persons and correlation between VAP?1 and Lp (a). We determined serum concentrations of lipids, lipoproteins , apolipoproteins and VAP?1 in 90 patients with psoriasis and 90 age matched controls. Serum Lp (a), apo A1 and apo B were measured by immunoprecipitation assays, and the lipids and lipoproteins were measured by enzymatic methods.The VAP?1 were masured by ELISA method. The mean levels of total cholesterol, LDL, apo B and VAP?1 in patients with psoriasis were found to be significantly higher than those of healthy subjects (P<0.05. In psoriatic patients, elevation of VAP‐1 correlated with elevation of Lp (a) (p = 0.025). This study shows that high serum lipid level and VAP?1, is significantly more common in psoriasis. This fact may be responsible for higher prevalence of cardiovascular accident in psoriatic patients. Copyright © 2012 John Wiley & Sons, Ltd. 相似文献
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Murtaza Mahmood ul Hassan Zuberi Amina Ahmad Muhammad Amir Imrana Kamran Muhammad Ahmad Manzoor 《Molecular biology reports》2020,47(7):5051-5060
Molecular Biology Reports - Nowadays, lower post-release survivorship of hatchery-reared fish in natural aquatic bodies has attained great attention and research is in progress to determine the... 相似文献
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Fernando López-Soto Nidia León-Sicairos Kamran Nazmi Jan G. Bolscher Mireya de la Garza 《Biometals》2010,23(3):563-568
Entamoeba histolytica is a parasitic protozoan that produces amoebiasis, an intestinal disease characterized by ulcerative colitis and dysentery.
In some cases, trophozoites can travel to the liver leading to hepatic abscesses and death. Recently, lactoferrin and lactoferricin
B have been shown to be amoebicidal in axenic cultures. The aim of this work was to determine whether the lactoferrin-peptides
lactoferricin amino acids 17–30, lactoferrampin amino acids 265–284, and lactoferrin chimera which is a fusion product of
the two peptides, are capable of producing a microbicidal effect to trophozoites of E. histolytica. We evaluated the killing effect of these peptides in growth kinetics carried out in axenic culture medium to which different
concentrations of peptides were added. At 50 μM of peptide concentration, lactoferricin and lactoferrampin had a moderate
amoebicidal effect, since a 45–50% of trophozoites remained viable at 24 h culture. However, at 50 μM of the lactoferrin chimera
75% amoeba were killed whereas at 100 μM all cells died. These data indicate that of lactoferrin-peptides mainly the chimera
have amoebicidal activity in a time- and concentration-dependent manner. The lactoferrin-peptides might be useful as therapeutic
agents against amoebiasis and thereby diminish the use of metronidazole, which is extremely toxic for the host. 相似文献