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961.
Allison R. Paules Nelson William T. Wiskes Nathaniel E. Seavy 《Journal of Field Ornithology》2021,92(1):43-53
Across their broad North American distribution, Hermit Thrushes (Catharus guttatus) exhibit extensive yet subtle intraspecific variation in morphology and diverse migration patterns, causing considerable debate regarding their systematics and an incomplete understanding of their migratory geography. To better understand the fall migration and wintering destinations of Hermit Thrushes in coastal California, we deployed geolocators on individuals of the subspecies C. g. slevini breeding in the Santa Cruz Mountains of the Coast Ranges. In 2014, we captured 20 Hermit Thrushes in Big Basin Redwoods State Park using mist‐nets and attached geolocators. In 2015, we retrieved tags from 13 birds. Tagged Hermit Thrushes left the breeding area between 1 and 19 September 2014 and arrived in wintering areas in Baja California Sur and northwestern mainland Mexico between 24 September and 13 October 2014. The average distance between breeding and wintering areas was 1617 ± 217 (SD) km, and the average duration of fall migration was 22.5 ± 6.4 (SD) days. Our results suggest that Hermit Thrushes breeding in Big Basin winter in a highly concentrated region of western Mexico including Baja California Sur and southwestern Sonora or northwestern‐most Sinaloa; we found no evidence that Big Basin birds overwintered in the southwestern United States. Our results also confirm the existence of chain migration for Hermit Thrushes in California. Because C. g. slevini exhibits a limited distribution in both breeding and wintering areas and their morphology and song suggest adaptation to their habitat, we recommend exploration of fine‐scale genetic structure of coastal California’s Hermit Thrushes to determine the extent of evolutionary divergence in this subspecies. 相似文献
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965.
Microbial pathogens bind host complement regulatory proteins to evade the immune system. The bacterial pathogen Neisseria meningitidis, or meningococcus, binds several complement regulators, including human Factor H (FH). FH binding protein (FHbp) is a component of two licensed meningococcal vaccines and in mice FHbp elicits antibodies that inhibit binding of FH to FHbp, which defeat the bacterial evasion mechanism. However, humans vaccinated with FHbp develop antibodies that enhance binding of FH to the bacteria, which could limit the effectiveness of the vaccines. In the present study, we show that two vaccine-elicited antibody fragments (Fabs) isolated from different human subjects increase binding of complement FH to meningococcal FHbp by ELISA. The two Fabs have different effects on the kinetics of FH binding to immobilized FHbp as measured by surface plasmon resonance. The 1.7- and 2.0-Å resolution X-ray crystal structures of the Fabs in complexes with FHbp illustrate that the two Fabs bind to similar epitopes on the amino-terminal domain of FHbp, adjacent to the FH binding site. Superposition models of ternary complexes of each Fab with FHbp and FH show that there is likely minimal contact between the Fabs and FH. Collectively, the structures reveal that the Fabs enhance binding of FH to FHbp by altering the conformations and mobilities of two loops adjacent to the FH binding site of FHbp. In addition, the 1.5 Å-resolution structure of one of the isolated Fabs defines the structural rearrangements associated with binding to FHbp. The FH-enhancing human Fabs, which are mirrored in the human polyclonal antibody responses, have important implications for tuning the effectiveness of FHbp-based vaccines. 相似文献
966.
International Journal of Primatology - 相似文献
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968.
Ocotea tenera (Lauraceae), an understory bird-dispersed tree, produces single-seeded fruits that vary in diameter from 1.4 to 2.4 cm. Much of the variation within a population at Monteverde, Costa Rica occurred within individual trees. The relative size of fruits produced by different trees remained generally constant over an 11-year period despite slight differences between years in the average size of fruits produced by a given tree.Fruit-eating birds could thus express their preferences for particular fruit size characteristics by choosing among trees that have distinct distributions of fruit diameters, and between individually variable fruits within trees. In a field study of individually marked fruits, birds removed 46.2% of fruits; the rest of the fruits were destroyed by invertebrate (25.3%) and vertebrate (4.3%) pulp-feeders or aborted by the plant after remaining ripe but uneaten for as long as 100 days (24.2%). The four major avian seed dispersers of O. tenera each have gape widths exceeding all but the largest fruits. Birds preferred plants with greater-than-average-sized fruits; within trees, they favored larger fruits, apparently because net pulp mass increases with fruit diameter. Fruits that ripened early in the season were more likely to be removed and were removed more quickly than late-ripening fruits.Based on mother-offspring regressions of mean fruit size, the phenotypic variation in fruit diameter in O. tenera is highly heritable, indicating the potential for an evolutionary response to selection by birds. Nonetheless, directional selection on fruit size or shape is likely to be inconsistent, constrained by genetic correlations, and weak compared to selection on traits like fecundity or phenology. 相似文献
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970.
A kinetic analysis and simulation of the replication reactions of two competing replicators—one non-metabolic (thermodynamic), the other metabolic, are presented. Our analysis indicates that in a rich resource environment the non-metabolic replicator is likely to be kinetically selected for over the metabolic replicator. However, in the more typical resource-poor environment it will be the metabolic replicator that is the kinetically more stable entity, and the one that will be kinetically selected for. Accordingly, a causal relationship between the emergence of a simple replicator and the emergence of a metabolic system is indicated. The results lend further support for the “replication first” school of thought in the origin of life problem by providing a mechanistic basis for the emergence of a metabolism, once a simple non-metabolic replicating system has itself been established. The study reaffirms our view that the roots of Darwinian theory may be found within standard chemical kinetic theory. 相似文献