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111.
Vimaleswaran KS Radha V Ramya K Babu HN Savitha N Roopa V Monalisa D Deepa R Ghosh S Majumder PP Rao MR Mohan V 《Human genetics》2008,123(6):599-605
Adiponectin is an adipose tissue specific protein that is decreased in subjects with obesity and type 2 diabetes. The objective
of the present study was to examine whether variants in the regulatory regions of the adiponectin gene contribute to type
2 diabetes in Asian Indians. The study comprised of 2,000 normal glucose tolerant (NGT) and 2,000 type 2 diabetic, unrelated
subjects randomly selected from the Chennai Urban Rural Epidemiology Study (CURES), in southern India. Fasting serum adiponectin
levels were measured by radioimmunoassay. We identified two proximal promoter SNPs (−11377C→G and −11282T→C), one intronic
SNP (+10211T→G) and one exonic SNP (+45T→G) by SSCP and direct sequencing in a pilot study (n = 500). The +10211T→G SNP alone was genotyped using PCR-RFLP in 4,000 study subjects. Logistic regression analysis revealed
that subjects with TG genotype of +10211T→G had significantly higher risk for diabetes compared to TT genotype [Odds ratio
1.28; 95% Confidence Interval (CI) 1.07–1.54; P = 0.008]. However, no association with diabetes was observed with GG genotype (P = 0.22). Stratification of the study subjects based on BMI showed that the odds ratio for obesity for the TG genotype was
1.53 (95%CI 1.3–1.8; P < 10−7) and that for GG genotype, 2.10 (95% CI 1.3–3.3; P = 0.002). Among NGT subjects, the mean serum adiponectin levels were significantly lower among the GG (P = 0.007) and TG (P = 0.001) genotypes compared to TT genotype. Among Asian Indians there is an association of +10211T→G polymorphism in the
first intron of the adiponectin gene with type 2 diabetes, obesity and hypoadiponectinemia. 相似文献
112.
Photo Wallahs . 1992. 60 minutes, color. A film by David and Judith MacDougall. For information contact the University of California Extension Center for Media and Independent Learning, 2000 Center Street, Fourth Floor, Berkeley, CA 94704, 510–642–0460. 相似文献
113.
Bodhendu B. Gupta Anjan Bhattacharyya Santi R. Mitra Narayan Adityachaudhury 《Phytochemistry》1983,22(5):1306-1307
The pods of Milletia auriculata have yielded a new substance, 5,7-dihydroxy-6-methoxy-4′-O-prenyloxyisoflavone. 相似文献
114.
Arenahalli Ningegowda Madhu Prashant Giribhattanavar Mandayam Singara Narayan Siddalingaiya Gurudutt Prapulla 《Biotechnology letters》2010,32(4):503-506
Vitamin B12 was produced by probiotic Lactobacillus plantarum in submerged fermentation (96 h) with successive anaerobic and aerobic phases of 48 h each to give 13 ng vitamin B12/g dry biomass. Sodium cyanide-mediated cell lysis, followed by benzyl alcohol/chloroform/water extraction, improved the release
of intracellular vitamin B12 for analysis. The presence of the K+ adduct of cyanocobalamin (m/z of 1394) was established using electron spray ionization–mass spectra; growth of a mutant of Escherichia coli in the presence of cyanocobalamin ascertained its bioavailability. 相似文献
115.
Martin M. Widelitz Marlene R. Coryell Narayan G. Avadhani 《Biochemical and biophysical research communications》1977,76(4):1223-1229
Administration of d-amphetamine to rats causes the dissociation of brain polysomes in a dose-dependent manner. Further, the dose of d-amphetamine required to induce a stereotypic state in rats coincides with the dose needed to cause polysome dissociation. The enantiomeric form, i.e. 1-amphetamine, is ineffective in inducing both the behavioral and biochemical changes even at a dose as high as 30 mg/kg. Clinically potent neuroleptics such as haloperidol and chlorpromazine can effectively reverse the polysome dissociation as well as the behavioral changes induced by a near toxic dose of d-amphetamine (15 mg/kg). 相似文献
116.
Aruna S. Jaiswal Harekrushna Panda Brian K. Law Jay Sharma Jitesh Jani Robert Hromas Satya Narayan 《PloS one》2015,10(5)
Recently approved chemotherapeutic agents to treat colorectal cancer (CRC) have made some impact; however, there is an urgent need for newer targeted agents and strategies to circumvent CRC growth and metastasis. CRC frequently exhibits natural resistance to chemotherapy and those who do respond initially later acquire drug resistance. A mechanism to potentially sensitize CRC cells is by blocking the DNA polymerase β (Pol-β) activity. Temozolomide (TMZ), an alkylating agent, and other DNA-interacting agents exert DNA damage primarily repaired by a Pol-β-directed base excision repair (BER) pathway. In previous studies, we used structure-based molecular docking of Pol-β and identified a potent small molecule inhibitor (NSC666715). In the present study, we have determined the mechanism by which NSC666715 and its analogs block Fen1-induced strand-displacement activity of Pol-β-directed LP-BER, cause apurinic/apyrimidinic (AP) site accumulation and induce S-phase cell cycle arrest. Induction of S-phase cell cycle arrest leads to senescence and apoptosis of CRC cells through the p53/p21 pathway. Our initial findings also show a 10-fold reduction of the IC50 of TMZ when combined with NSC666715. These results provide a guide for the development of a target-defined strategy for CRC chemotherapy that will be based on the mechanisms of action of NSC666715 and TMZ. This combination strategy can be used as a framework to further reduce the TMZ dosages and resistance in CRC patients. 相似文献
117.
Narayan Chakor Ganesh Patil Diana Writer Giridharan Periyasamy Rajiv Sharma Abhijit Roychowdhury Prabhu Dutt Mishra 《Bioorganic & medicinal chemistry letters》2012,22(21):6608-6610
The first total synthesis of prasinic acid is being reported along with its biological evaluation. The ten step synthesis involved readily available and cheap starting materials and can easily be transposed to large scale manufacturing. The crucial steps of the synthesis included the formation of two different aromatic units (7 and 9) and their coupling reaction. The synthetic prasinic acid exhibited moderate antitumor activity (IC50 4.3–9.1 μM) in different lines of cancer cells. 相似文献
118.
Abhishek Sharma Satyawati Sharma Aditya Mittal Satya Narayan Naik 《Annals of microbiology》2014,64(2):515-520
The development of biofriendly and economical alternatives to chemical pesticides is a globally important scientific challenge. In this work, Karanja-based media conditions were optimized for obtaining high production of biomass and spores of a biocontrol agent, the entomopathogenic fungus Paecilomyces lilacinus 6029, using a two-step statistical approach coupled with rigorous experimentation. In the first step, non-edible Karanja cake was screened out as a major substrate from other oil cakes. In the second step, biomass production was maximized by applying response surface methodology to experimental variations in key physico-chemical factors: carbon/nitrogen (C/N) ratio and pH. This approach eventually predicted a maximum biomass production of 10.559 g/l with a medium having a C/N ratio of 35.88 and pH 5.9. An experimental production of 10.529 g/l biomass was obtained. The remarkable agreement between the predicted and the experimentally obtained biomass confirm the validity of the approach utilized to maximize production of P. lilacinus. 相似文献
119.
Tripathi Laxmi Narayan Praveena M. Johns Ben Basu Jaydeep Kumar 《Plasmonics (Norwell, Mass.)》2018,13(5):1811-1816
Plasmonics - Nanoantenna-enhanced ultrafast emission from colloidal quantum dots as quantum emitters is required for fast quantum communications. On-chip integration of such devices requires a... 相似文献
120.
Thong Huy Cao Donald J. L. Jones Paulene A. Quinn Daniel Chu Siong Chan Narayan Hafid Helen M. Parry Mohapradeep Mohan Jatinderpal K. Sandhu Stefan D. Anker John G. Cleland Kenneth Dickstein Gerasimos Filippatos Hans L. Hillege Marco Metra Piotr Ponikowski Nilesh J. Samani Dirk J. Van Veldhuisen Faiez Zannad Aeilko H. Zwinderman Adriaan A. Voors Chim C. Lang Leong L. Ng 《Clinical proteomics》2018,15(1):35